公开(公告)号：EP3212140A4

公开(公告)日：2018-08-01

申请号：EP15855328

申请日：2015-10-27

申请人： AVEDRO INC

发明人： FRIEDMAN MARC ,  KAMAEV PAVEL ,  SMIRNOV MIKHAIL

IPC分类号： A61F9/007 ,  A61F9/008 ,  A61N5/06

CPC分类号： A61F9/0079 ,  A61F9/007 ,  A61F9/008 ,  A61F9/00825 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/00893

摘要： A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

公开(公告)号：EP3285704A1

公开(公告)日：2018-02-28

申请号：EP16784078

申请日：2016-04-25

申请人： AVEDRO INC

发明人： FRIEDMAN MARC ,  SMIRNOV MIKHAIL ,  KAMAEV PAVEL

IPC分类号： A61F9/00 ,  A61N5/06

CPC分类号： A61N5/0624 ,  A61F9/029 ,  A61M2202/0208 ,  A61M2205/3368 ,  A61M2205/36 ,  A61M2205/52 ,  A61M2210/0612 ,  A61N5/062 ,  A61N2005/0626 ,  A61N2005/0648 ,  A61N2005/0661

摘要： An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

公开(公告)号：EP2999471A4

公开(公告)日：2017-01-25

申请号：EP14800815

申请日：2014-05-19

申请人： AVEDRO INC

发明人： KAMAEV PAVEL ,  FRIEDMAN MARC ,  SHERR EVAN ,  MULLER DAVID

IPC分类号： A61K31/495 ,  A61K31/525 ,  A61K33/26 ,  A61K33/40 ,  A61K41/00 ,  A61P27/02 ,  A61P27/10

CPC分类号： A61K33/26 ,  A61K31/121 ,  A61K31/122 ,  A61K31/47 ,  A61K31/498 ,  A61K31/519 ,  A61K31/525 ,  A61K33/40 ,  A61K41/00 ,  A61K45/06 ,  A61N5/062 ,  A61K2300/00

摘要： Various agents and additives for cross-linking treatments are identified in disclosed studies. The characteristics of the various agents and additives may be advantageously employed in formulations applied in cross-linking treatments of the eye. In some embodiments, riboflavin is combined with Iron(II) to enhance the cross-linking activity generated by the riboflavin. In other embodiments, cross-linking treatments employ an Iron(II) solution in combination with a hydrogen peroxide pre-soak. In yet other embodiments, 2,3-butanedione is employed to increase the efficacy of corneal cross-linking with a photosensitizer, such as riboflavin. In further embodiments, folic acid is employed in combination with a photosensitizer, such as riboflavin, to enhance cross-linking activity. In yet further embodiments, 2,3-butanedione, folic acid, a quinoxaline, a quinoline, dibucaine, Methotrexate, menadione, or a derivative thereof is applied as a cross-linking agent.

公开(公告)号：EP2547298A4

公开(公告)日：2013-11-20

申请号：EP11757076

申请日：2011-03-18

申请人： AVEDRO INC

发明人： MULLER DAVID ,  MARSHALL JOHN ,  FRIEDMAN MARC ,  BLINN STEPHEN ,  SCHARF RONALD ,  KAMAEV PAVEL ,  PERTAUB RADHA

IPC分类号： A61F9/00 ,  A61B3/10 ,  A61B3/107 ,  A61F9/008 ,  A61M35/00 ,  A61N5/06

CPC分类号： A61N5/0625 ,  A61B3/10 ,  A61B3/107 ,  A61F9/00 ,  A61F9/0079 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61N5/062 ,  A61N2005/0643 ,  A61N2005/0661 ,  A61N2005/067

摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

摘要翻译： 用于在眼睛疗法治疗之后激活角膜组织内的交联以稳定和加强角膜组织的装置和方法。 提供反馈系统来获取测量结果并将反馈信息传递给控制器​​。 反馈系统可以包括干涉仪系统，角膜偏振测量系统或用于监测角膜内交联活动的其他配置。 控制器适于分析反馈信息并基于该信息调整对眼睛的治疗。 反馈系统的各个方面也可以用于监视和诊断眼睛1的特征。还提供了根据反馈系统提供的信息激活交联以提高交联治疗的准确性和安全性的方法。

公开(公告)号：EP3226871A4

公开(公告)日：2018-07-25

申请号：EP15864372

申请日：2015-12-02

申请人： AVEDRO INC

发明人： KAMAEV PAVEL ,  FRIEDMAN MARC ,  SHERR EVAN ,  PETERSON SARAH M ,  MULLER DAVID

IPC分类号： A61K31/525 ,  A61F9/007 ,  A61K33/26 ,  A61K41/00 ,  A61L31/14 ,  A61N5/06 ,  A61P27/02

CPC分类号： A61K41/00 ,  A61F9/0079 ,  A61K31/525 ,  A61K33/26 ,  A61K47/02 ,  A61K47/12 ,  A61L31/14 ,  A61L2430/16 ,  A61N5/062 ,  A61P27/02 ,  A61K2300/00

摘要： Systems, methods, and compositions generate cross-linking activity for treatment of eye disorders. Various agents, additives, buffers, etc., may be employed in formulations with a cross-linking agent to enhance treatment. For example, a composition for applying treatment to a cornea of an eye includes a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light. The composition also includes an iron additive and citrate buffer. In some cases, the cross-linking agent may include riboflavin. In other cases, the iron additive may include FeSO4. In further cases, the iron additive may be dissolved in the citrate buffer.

公开(公告)号：EP2712311A4

公开(公告)日：2014-12-03

申请号：EP12774641

申请日：2012-04-03

申请人： AVEDRO INC

发明人： MULLER DAVID ,  MARSHALL JOHN ,  FRIEDMAN MARC ,  BLINN STEPHEN ,  SCHARF STEPHEN ,  KAMAEV PAVEL ,  PERTAUB RADHA

IPC分类号： A61F9/01 ,  A61B18/00 ,  A61F9/007 ,  A61F9/008 ,  A61N5/06

CPC分类号： A61N5/062 ,  A61B2018/00619 ,  A61F9/0079 ,  A61F2009/00844 ,  A61F2009/00872 ,  A61F2009/00882

摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.