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公开(公告)号：EP2635247A1
公开(公告)日：2013-09-11
申请号：EP11785864.7
申请日：2011-11-04
IPC分类号： A61J3/06
CPC分类号： A61K9/2095 , A61J3/06 , A61J3/10
摘要： The present invention relates to a process for producing monolithic tablets. The method employs a melt-processed composition containing at least on active agent and at least one thermoplastic binder. The invention further relates to a method for cutting and deflashing a belt of pre-shaped bodies of a melt-processed composition, wherein the pre-shaped bodies are interconnected by flash.
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2.发明公开METHOD FOR PRODUCING MONOLITHIC TABLETS 审中-公开VERFAHREN ZUR HERSTELLUNG VON MONOLITHISCHEN TABLETTEN
公开(公告)号：EP3124008A1
公开(公告)日：2017-02-01
申请号：EP16189646.9
申请日：2011-11-04
IPC分类号： A61J3/06
CPC分类号： A61K9/2095 , A61J3/06 , A61J3/10
摘要： The present invention relates to a process for producing monolithic tablets. The method employs a melt-processed composition containing at least on active agent and at least one thermoplastic binder. The invention further relates to a method for cutting and deflashing a belt of pre-shaped bodies of a melt-processed composition, wherein the pre-shaped bodies are interconnected by flash.
摘要翻译： 本发明涉及一种整体式片剂的制造方法。 该方法使用至少含有活性剂和至少一种热塑性粘合剂的熔融加工组合物。 本发明还涉及一种用于对熔融加工的组合物的预成形体的带进行切割和去屑的方法，其中预成形体通过闪光相互连接。
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公开(公告)号：EP2635258A1
公开(公告)日：2013-09-11
申请号：EP11784893.7
申请日：2011-11-04
CPC分类号： A61K9/2077 , A61K9/146 , A61K9/2054
摘要： In one embodiment, the present invention relates to abuse-deterrent drug formulations comprise a plurality of discrete domains uniformly dispersed in a pharmaceutically acceptable matrix, wherein said domains have high fracture toughness and comprise at least one polymer and at least one abuse-relevant drug. In another embodiment, the present invention relates to a formulation comprising a plurality of discrete mechanically reinforcing particles uniformly dispersed in a pharmaceutically acceptable matrix, wherein said matrix has high fracture toughness and comprises at least one polymer and at least one active agent, at least one abuse-relevant drug or a combination of at least one active agent and at least one abuse-relevant drug.
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公开(公告)号：EP2303242B1
公开(公告)日：2018-05-02
申请号：EP09772440.5
申请日：2009-06-30
CPC分类号： A61K47/32 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K9/2095
摘要： A pharmaceutical dosage form comprises a solid dispersion product of at least one active ingredient dispersed in a polymeric binder composition, the polymeric carrier composition comprising a) a vinylpyrrolidone homopolymer, wherein at least 95 % by weight of the vinylpyrrolidone homopolymer has a molecular weight distribution within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight-average molecular weight of from 5000 to 1 500 000. The dosage form is preferably prepared by a melt extrusion process. The polymeric carrier composition exhibits a high drug dissolution power and allows a reduction of the viscosity of the melt without deteriorating the mechanical properties and storage stability of the dosage form.
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公开(公告)号：EP2635247B1
公开(公告)日：2016-12-14
申请号：EP11785864.7
申请日：2011-11-04
IPC分类号： A61J3/06
CPC分类号： A61K9/2095 , A61J3/06 , A61J3/10
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公开(公告)号：EP3071184A1
公开(公告)日：2016-09-28
申请号：EP14805204.6
申请日：2014-11-18
发明人： LIEPOLD, Bernd , MOOSMANN, Anna , PAULI, Mirko , DURAK, Fatih , KESSLER, Thomas , HOELIG, Peter , ROSENBLAT, Karin , KOSTELAC, Drazen
IPC分类号： A61K9/00 , A61K47/14 , A61K47/22 , A61K47/32 , A61K9/14 , A61K9/20 , A61K31/427 , A61K31/4025 , A61K31/497 , A61P31/22
CPC分类号： A61K38/06 , A61K9/145 , A61K9/146 , A61K9/2013 , A61K9/2027 , A61K9/2095 , A61K31/4025 , A61K31/427 , A61K31/497 , A61K38/05 , A61K2300/00
摘要： The present invention features solid pharmaceutical compositions comprising Compound 1 (or a pharmaceutically acceptable salt thereof), Compound 2 (or a pharmaceutically acceptable salt thereof), and ritonavir (a pharmaceutically acceptable salt thereof), which are co-formulated in amorphous solid dispersion comprising a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant.
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公开(公告)号：EP3089757A1
公开(公告)日：2016-11-09
申请号：EP15701431.7
申请日：2015-01-02
发明人： MILLER, Jonathan M. , MORRIS, John B. , SEVER, Nancy E. , SCHMITT, Eric A. , GAO, Ping X. , SHI, Yi , GAO, Yi , LIEPOLD, Bernd , MOOSMANN, Anna , PAULI, Mirko , DURAK, Fatih , KESSLER, Thomas , HOELIG, Peter A. , ROSENBLATT, Karin , KOSTELAC, Drazen , GOKHALE, Rajeev , COSTELLO, Mark , KNABLE, Carl
IPC分类号： A61K47/32 , A61K47/38 , A61K9/24 , A61K31/4025 , A61K31/427 , A61K31/497 , A61K31/513 , A61P31/14
CPC分类号： A61K31/513 , A61K9/209 , A61K31/4025 , A61K31/427 , A61K31/497 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection.
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