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1.发明授权
公开(公告)号：EP2970215B1
公开(公告)日：2019-04-17
申请号：EP14710280.0
申请日：2014-03-14
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying X. , ZHAO, Hongyu H. , LI, Huan-Qiu , BREWER, Jason T. , ZANZE, Irini , DIETRICH, Justin , VASUDEVAN, Anil , DJURIC, Stevan, W. , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D207/48 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61P25/00
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公开(公告)号：EP3288939A1
公开(公告)日：2018-03-07
申请号：EP16721023.6
申请日：2016-04-15
申请人： AbbVie Inc.
发明人： BREINLINGER, Eric, C. , COX, Phil, B. , DAANEN, Jerome , DIETRICH, Justin , DJURIC, Stevan , DOMBROWSKI, Amanda, W. , FRANK, Kristine, E. , FRIEDMAN, Michael, M. , GOMTSYAN, Arthur , LI, Huan-Qui , LONGENECKER, Kenton , OSUMA, Augustine , ROWLEY, Ann, Marie , SCHMIDT, Robert , VASUDEVAN, Anil , WILSON, Noel
IPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04 , C07D471/14 , C07D471/18 , C07D487/04 , C07D491/147 , C07D491/22 , C07D498/04 , C07D498/14 , C07D498/18 , C07D498/20 , C07D498/22 , C07D519/00
摘要： The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.
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3.发明公开PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开吡咯烷，药物组合物ORDER及其在治疗中
公开(公告)号：EP2970215A1
公开(公告)日：2016-01-20
申请号：EP14710280.0
申请日：2014-03-14
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying X. , ZHAO, Hongyu H. , LI, Huan-Qiu , BREWER, Jason T. , ZANZE, Irini , DIETRICH, Justin , VASUDEVAN, Anil , DJURIC, Stevan, W. , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D207/48 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/12 , C07D207/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to pyrrolidine derivatives of formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.
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