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公开(公告)号：EP3013337B1
公开(公告)日：2018-10-31
申请号：EP14817453.5
申请日：2014-06-26
申请人： Abbvie Inc.
发明人： BONAFOUX, Dominique , DAVIS, Heather, M. , FRANK, Kristine, E. , FRIEDMAN, Michael, M. , HEROLD, J., Martin , HOEMANN, Michael, Z. , HUNTLEY, Raymond , OSUMA, Augustine , SHEPPARD, George , SOMAL, Gagandeep, K. , VAN CAMP, Jennifer , VAN EPPS, Stacy, A. , VASUDEVAN, Anil , WALLACE, Grier, A. , WANG, Lu , WANG, Lu , WANG, Zhi , WILSON, Noel, S. , XU, Xiangdong
IPC分类号： C07D405/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D209/10 , C07D209/12 , C07D209/14
CPC分类号： C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号：EP2299821B1
公开(公告)日：2015-11-04
申请号：EP09763424.0
申请日：2009-06-09
申请人： AbbVie Inc.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： A01N43/42 , C07D487/14 , C07D498/14 , C07D513/14
CPC分类号： C07D487/14 , C07D498/14 , C07D513/14
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公开(公告)号：EP4008328A1
公开(公告)日：2022-06-08
申请号：EP21194489.7
申请日：2014-06-26
申请人： AbbVie Inc.
发明人： BONAFOUX, Dominique , DAVIS, Heather, M. , FRANK, Kristine, E. , FRIEDMAN, Michael, M. , HEROLD, J. Martin , HOEMANN, Michael, Z. , HUNTLEY, Raymond , OSUMA, Augustine , SHEPPARD, George , SOMAL, Gagandeep, K. , VAN CAMP, Jennifer , VAN EPPS, Stacy, A. , VASUDEVAN, Anil , WALLACE, Grier, A. , WANG, Lu , WANG, Lu , WANG, Zhi , WILSON, Noel, S. , XU, Xiangdong
IPC分类号： A61K31/405 , A61K31/454 , A61K31/4545 , C07D217/22 , C07D401/14 , C07D231/56 , C07D401/12 , C07D403/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D209/08
摘要： The invention provides compounds of Formula (I)
pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.-
公开(公告)号：EP3031324A3
公开(公告)日：2016-09-07
申请号：EP15192686.2
申请日：2009-06-09
申请人： AbbVie Inc.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： A01N43/42 , C07D487/14 , C07D498/14 , C07D513/14
CPC分类号： C07D487/14 , C07D498/14 , C07D513/14
摘要： The invention provides a compound of Formula (Ie), pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（Ie）的化合物，其药学上可接受的盐，前药，生物活性代谢产物，立体异构体和异构体，其中所述变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：EP3013337A1
公开(公告)日：2016-05-04
申请号：EP14817453.5
申请日：2014-06-26
申请人： Abbvie Inc.
发明人： BONAFOUX, Dominique , DAVIS, Heather, M. , FRANK, Kristine, E. , FRIEDMAN, Michael, M. , HEROLD, J., Martin , HOEMANN, Michael, Z. , HUNTLEY, Raymond , OSUMA, Augustine , SHEPPARD, George , SOMAL, Gagandeep, K. , VAN CAMP, Jennifer , VAN EPPS, Stacy, A. , VASUDEVAN, Anil , WALLACE, Grier, A. , WANG, Lu , WANG, Lu , WANG, Zhi , WILSON, Noel, S. , XU, Xiangdong
IPC分类号： A61K31/405 , A61K31/454 , A61K31/4545 , C07D217/22
CPC分类号： C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention provides carboxamide compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions, including rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, Crohn's disease, inflammatory bowel disease, ulcerative colitis, psoriatic arthritis, psoriasis, ankylosing spondylitis, interstitial cystitis, asthma, systemic lupus erythematosus, lupus nephritis, B cell chronic lymphocytic lymphoma, multiple sclerosis, chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, B-cell non-Hodgkin's lymphoma, activated B-celllike diffuse large B-cell, lymphoma, multiple myeloma, diffuse large B-celllymphoma, follicular lymphoma, hairy cell leukemia or Lymphoblastic lymphoma.
摘要翻译： 本发明提供式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫和肿瘤病症。
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公开(公告)号：EP3950692A1
公开(公告)日：2022-02-09
申请号：EP21173353.0
申请日：2010-12-01
申请人： AbbVie Inc.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
摘要： The invention provides compounds of Formula (I) and Formula (II)
pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.-
公开(公告)号：EP3266786A1
公开(公告)日：2018-01-10
申请号：EP17171010.6
申请日：2010-12-01
申请人： AbbVie Inc.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： C07D487/14 , C07D471/14 , C07D498/14 , C07D513/14 , A61K31/06 , A61K31/437 , A61K31/4985 , A61P19/00
CPC分类号： C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
摘要： The invention provides compounds of Formula (I) and Formula (II)
pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.摘要翻译： 本发明提供式（I）和式（II）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：EP2506716B1
公开(公告)日：2017-05-17
申请号：EP10835061.2
申请日：2010-12-01
申请人： AbbVie Inc.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： C07D487/14 , C07D471/14 , C07D498/14 , C07D513/14 , A61K31/437 , A61K31/4985 , A61P19/00
CPC分类号： C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
摘要： The invention provides compounds of Formula (I) and Formula (II) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（I）和式（II）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫和肿瘤病症。
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公开(公告)号：EP3031324A2
公开(公告)日：2016-06-15
申请号：EP15192686.2
申请日：2009-06-09
申请人： AbbVie Inc.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： A01N43/42 , C07D487/14 , C07D498/14 , C07D513/14
CPC分类号： C07D487/14 , C07D498/14 , C07D513/14
摘要： The invention provides a compound of Formula (Ie), pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（Ie）的化合物，其药学上可接受的盐，前体药物，生物活性代谢物，立体异构体和异构体，其中所述变量在本文中定义。 本发明的化合物可用于治疗免疫和肿瘤病症。
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公开(公告)号：EP3483167A1
公开(公告)日：2019-05-15
申请号：EP18202730.0
申请日：2014-06-26
申请人： AbbVie Inc.
发明人： BONAFOUX, Dominique , DAVIS, Heather, M. , FRANK, Kristine, E. , FRIEDMAN, Michael, M. , HEROLD, J. Martin , HOEMANN, Michael, Z. , HUNTLEY, Raymond , OSUMA, Augustine , SHEPPARD, George , SOMAL, Gagandeep, K. , VAN CAMP, Jennifer , VAN EPPS, Stacy, A. , VASUDEVAN, Anil , WALLACE, Grier, A. , WANG, Lu , WANG, Lu , WANG, Zhi , WILSON, Noel, S. , XU, Xiangdong
IPC分类号： C07D513/04 , A61P35/00 , A61K31/429
摘要： The invention provides compounds of Formula (I)
pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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