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1.发明授权
公开(公告)号：EP3681864B1
公开(公告)日：2020-10-28
申请号：EP18779798.0
申请日：2018-09-13
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
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2.发明公开
公开(公告)号：EP3681864A1
公开(公告)日：2020-07-22
申请号：EP18779798.0
申请日：2018-09-13
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
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3.发明公开
公开(公告)号：EP3736270A1
公开(公告)日：2020-11-11
申请号：EP20183402.5
申请日：2018-09-13
发明人： ALTENBACH, Robert J , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D401/12 , C07D213/71 , C07D215/36 , C07D231/56 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
摘要： Compounds of Formula (I) are disclosed:
wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. Also disclosed is the use of the compounds in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering the compounds.-
4.发明公开
公开(公告)号：EP3865474A1
公开(公告)日：2021-08-18
申请号：EP21164249.1
申请日：2018-09-13
发明人： ALTENBACH, Robert J , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C. , MAI, Thi Thu Trang
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
摘要： The invention discloses compounds of Formula (I):
wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. Also disclosed are methods for their production and methods of treating cystic fibrosis by administering the compounds.-
5.发明公开
公开(公告)号：EP3736267A1
公开(公告)日：2020-11-11
申请号：EP20183405.8
申请日：2018-09-13
发明人： ALTENBACH, Robert J , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D215/36 , C07D213/64 , C07D213/71 , C07D231/56 , C07D235/28 , C07D401/12 , C07D471/04 , C07C311/45 , A61P11/00 , A61K31/4709
摘要： Compounds of Formula (I) are disclosed:
wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. Also disclosed is the use of the compounds in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering the compounds.-
6.发明公开
公开(公告)号：EP3585784A1
公开(公告)日：2020-01-01
申请号：EP18710151.4
申请日：2018-02-23
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , DESROY, Nicolas , GFESSER, Gregory A. , GRESZLER, Stephen N. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D405/12 , C07D407/12 , C07D319/22 , C07D307/16 , A61P3/04 , A61K31/381 , A61K31/343
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