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公开(公告)号：EP3322697A1
公开(公告)日：2018-05-23
申请号：EP16739584.7
申请日：2016-07-14
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COWART, Marlon D. , ESMIEU, William Ramesh , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc J. , SEARLE, Xenia B. , VOIGHT, Eric , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D317/70 , C07D405/12 , C07D407/12 , C07D493/04 , C07D519/00 , A61K31/36 , A61K31/404 , A61K31/426 , A61K31/433 , A61K31/443 , A61K31/4184 , A61K31/501 , A61K31/497 , A61P11/00
摘要： wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：EP3523277A1
公开(公告)日：2019-08-14
申请号：EP17794414.7
申请日：2017-10-04
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , DESROY, Nicolas , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , SCANIO, Marc J. , SEARLE, Xenia , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D207/16 , C07D401/12 , A61K31/4025 , A61K31/4439 , A61P11/00
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3.发明公开
公开(公告)号：EP3585784A1
公开(公告)日：2020-01-01
申请号：EP18710151.4
申请日：2018-02-23
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , DESROY, Nicolas , GFESSER, Gregory A. , GRESZLER, Stephen N. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D405/12 , C07D407/12 , C07D319/22 , C07D307/16 , A61P3/04 , A61K31/381 , A61K31/343
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公开(公告)号：EP3322697B1
公开(公告)日：2019-12-18
申请号：EP16739584.7
申请日：2016-07-14
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COWART, Marlon D. , ESMIEU, William Ramesh , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc J. , SEARLE, Xenia B. , VOIGHT, Eric , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D317/70 , C07D405/12 , C07D407/12 , C07D493/04 , C07D519/00 , A61K31/36 , A61K31/404 , A61K31/426 , A61K31/433 , A61K31/443 , A61K31/4184 , A61K31/501 , A61K31/497 , A61P11/00
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公开(公告)号：EP3303294A1
公开(公告)日：2018-04-11
申请号：EP16736610.3
申请日：2016-05-25
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , COWART, Marlon D. , DE MUNCK, Tom Roger Lisette , DROPSIT MONTOVERT, Sebastien Jean Jacques Cedric , GFESSER, Gregory A. , KELGTERMANS, Hans , MARTINA, Sebastien Laurent Xavier , VAN DER PLAS, Steven Emiel , WANG, Xueqing
IPC分类号： C07D213/81 , A61K31/44 , A61P11/00
CPC分类号： C07D213/81 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D491/107
摘要： wherein X, R1, R2, and R3 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
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公开(公告)号：EP3359539A1
公开(公告)日：2018-08-15
申请号：EP16785567.5
申请日：2016-10-07
申请人： AbbVie S.À.R.L. , Galapagos NV
发明人： AKKARI, Rhalid , ALVEY, Luke Jonathan , BOCK, Xavier Marie , CLAES, Pieter Isabelle Roger , COWART, Marlon D. , DE LEMOS, Elsa , DESROY, Nicolas , DUTHION, Béranger , GFESSER, Gregory A. , GOSMINI, Romain Luc Marie , HOUSSEMAN, Christopher Gaëtan , JANSEN, Koen Karel , JI, Jianguo , KYM, Philip R. , LEFRANCOIS, Jean-Michel , MAMMOLITI, Oscar , MENET, Christel Jeanne Marie , NEWSOME, Gregory John Robert , PALISSE, Adeline Marie Elise , PATEL, Sachin V. , PIZZONERO, Mathieu Rafaël , SHRESTHA, Anurupa , SWIFT, Elizabeth C. , VAN DER PLAS, Steven Emiel , WANG, Xueqing
IPC分类号： C07D471/04 , A61K31/437 , A61P11/12 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： wherein R1, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号：EP3523293A1
公开(公告)日：2019-08-14
申请号：EP17794779.3
申请日：2017-10-06
申请人： Abbvie S.a.r.l. , Galapagos N.V.
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DE LEMOS, Elsa , DESROY, Nicolas , DUTHION, Béranger , GFESSER, Gregory A. , GRESZLER, Stephen N. , HOUSSEMAN, Christopher Gaëtan , KOENIG, John R. , KYM, Philip R. , LIU, Bo , SCANIO, Marc J. , SEARLE, Xenia , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D401/14 , C07D401/04 , C07D405/06 , C07D207/14 , C07D207/48 , A61P11/00 , A61K31/4025
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8.发明公开
公开(公告)号：EP3681864A1
公开(公告)日：2020-07-22
申请号：EP18779798.0
申请日：2018-09-13
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
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9.发明授权
公开(公告)号：EP3681864B1
公开(公告)日：2020-10-28
申请号：EP18779798.0
申请日：2018-09-13
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
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公开(公告)号：EP3359541B1
公开(公告)日：2020-08-05
申请号：EP16788232.3
申请日：2016-10-07
发明人： AKKARI, Rhalid , ALVEY, Luke Jonathan , BOCK, Xavier Marie , BROWN, Brian S. , CLAES, Pieter Isabelle Roger , COWART, Marlon D. , DE LEMOS, Elsa , DESROY, Nicolas , DUTHION, Béranger , GFESSER, Gregory A. , GOSMINI, Romain Luc Marie , HOUSSEMAN, Christopher Gaëtan , JANSEN, Koen Karel , JI, Jianguo , KYM, Philip R. , LEFRANCOIS, Jean-Michel , MAMMOLITI, Oscar , MENET, Christel Jeanne Marie , MERAYO, Nuria Merayo , NEWSOME, Gregory John Robert , PALISSE, Adeline Marie Elise , PATEL, Sachin V. , PIZZONERO, Mathieu Rafaël , SHRESTHA, Anurupa , SWIFT, Elizabeth C. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , DE BLIECK, Ann
IPC分类号： C07D471/04 , A61K31/437 , A61P11/12 , C07D519/00
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