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公开(公告)号：EP3322697A1
公开(公告)日：2018-05-23
申请号：EP16739584.7
申请日：2016-07-14
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COWART, Marlon D. , ESMIEU, William Ramesh , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc J. , SEARLE, Xenia B. , VOIGHT, Eric , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D317/70 , C07D405/12 , C07D407/12 , C07D493/04 , C07D519/00 , A61K31/36 , A61K31/404 , A61K31/426 , A61K31/433 , A61K31/443 , A61K31/4184 , A61K31/501 , A61K31/497 , A61P11/00
摘要： wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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2.发明公开
公开(公告)号：EP3585784A1
公开(公告)日：2020-01-01
申请号：EP18710151.4
申请日：2018-02-23
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , DESROY, Nicolas , GFESSER, Gregory A. , GRESZLER, Stephen N. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D405/12 , C07D407/12 , C07D319/22 , C07D307/16 , A61P3/04 , A61K31/381 , A61K31/343
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公开(公告)号：EP3322697B1
公开(公告)日：2019-12-18
申请号：EP16739584.7
申请日：2016-07-14
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COWART, Marlon D. , ESMIEU, William Ramesh , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc J. , SEARLE, Xenia B. , VOIGHT, Eric , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D317/70 , C07D405/12 , C07D407/12 , C07D493/04 , C07D519/00 , A61K31/36 , A61K31/404 , A61K31/426 , A61K31/433 , A61K31/443 , A61K31/4184 , A61K31/501 , A61K31/497 , A61P11/00
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4.发明授权
公开(公告)号：EP3681864B1
公开(公告)日：2020-10-28
申请号：EP18779798.0
申请日：2018-09-13
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
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5.发明公开
公开(公告)号：EP3681864A1
公开(公告)日：2020-07-22
申请号：EP18779798.0
申请日：2018-09-13
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COUTY, Sylvain , DESROY, Nicolas , GFESSER, Gregory A. , HOUSSEMAN, Christopher Gaëtan , KYM, Philip R. , LIU, Bo , MAI, Thi Thu Trang , MALAGU, Karine Fabienne , MERAYO MERAYO, Nuria , PICOLET, Olivier Laurent , PIZZONERO, Mathieu Rafaël , SEARLE, Xenia B. , VAN DER PLAS, Steven Emiel , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D213/71 , C07D215/36 , C07D231/56 , C07D401/12 , C07D235/28 , C07D471/04 , C07D213/64 , C07C311/45 , A61P11/00 , A61K31/4709
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公开(公告)号：EP3448842A1
公开(公告)日：2019-03-06
申请号：EP17722167.8
申请日：2017-04-24
申请人： AbbVie S.À.R.L. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , CHAN, Vincent , GRIEME, Timothy A. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc , SEARLE, Xenia B. , SHEKHAR, Shashank , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D311/58 , A61K31/352 , C07D311/60 , C07D407/12 , C07D407/14 , A61P11/00
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