公开(公告)号：EP3359539A1

公开(公告)日：2018-08-15

申请号：EP16785567.5

申请日：2016-10-07

申请人： AbbVie S.À.R.L. ,  Galapagos NV

发明人： AKKARI, Rhalid ,  ALVEY, Luke Jonathan ,  BOCK, Xavier Marie ,  CLAES, Pieter Isabelle Roger ,  COWART, Marlon D. ,  DE LEMOS, Elsa ,  DESROY, Nicolas ,  DUTHION, Béranger ,  GFESSER, Gregory A. ,  GOSMINI, Romain Luc Marie ,  HOUSSEMAN, Christopher Gaëtan ,  JANSEN, Koen Karel ,  JI, Jianguo ,  KYM, Philip R. ,  LEFRANCOIS, Jean-Michel ,  MAMMOLITI, Oscar ,  MENET, Christel Jeanne Marie ,  NEWSOME, Gregory John Robert ,  PALISSE, Adeline Marie Elise ,  PATEL, Sachin V. ,  PIZZONERO, Mathieu Rafaël ,  SHRESTHA, Anurupa ,  SWIFT, Elizabeth C. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P11/12 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D519/00 ,  A61K2300/00

摘要： wherein R1, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：EP3359541A1

公开(公告)日：2018-08-15

申请号：EP16788232.3

申请日：2016-10-07

申请人： AbbVie S.À.R.L. ,  Galapagos NV

发明人： AKKARI, Rhalid ,  ALVEY, Luke Jonathan ,  BOCK, Xavier Marie ,  BROWN, Brian S. ,  CLAES, Pieter Isabelle Roger ,  COWART, Marlon D. ,  DE LEMOS, Elsa ,  DESROY, Nicolas ,  DUTHION, Béranger ,  GFESSER, Gregory A. ,  GOSMINI, Romain Luc Marie ,  HOUSSEMAN, Christopher Gaëtan ,  JANSEN, Koen Karel ,  JI, Jianguo ,  KYM, Philip R. ,  LEFRANCOIS, Jean-Michel ,  MAMMOLITI, Oscar ,  MENET, Christel Jeanne Marie ,  MERAYO, Nuria Merayo ,  NEWSOME, Gregory John Robert ,  PALISSE, Adeline Marie Elise ,  PATEL, Sachin V. ,  PIZZONERO, Mathieu Rafaël ,  SHRESTHA, Anurupa ,  SWIFT, Elizabeth C. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing ,  DE BLIECK, Ann

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P11/12 ,  C07D519/00

摘要： wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：EP3359540A1

公开(公告)日：2018-08-15

申请号：EP16785568.3

申请日：2016-10-07

申请人： AbbVie S.À.R.L. ,  Galapagos NV

发明人： AKKARI, Rhalid ,  ALVEY, Luke Jonathan ,  BOCK, Xavier Marie ,  BROWN, Brian S. ,  CLAES, Pieter Isabelle Roger ,  COWART, Marlon D. ,  CONRATH, Katja E. ,  CYR, Douglas ,  DE LEMOS, Elsa ,  DE WILDE, Gert Jules Hector ,  DESROY, Nicolas ,  DUTHION, Béranger ,  GFESSER, Gregory A. ,  GOSMINI, Romain Luc Marie ,  HOUSSEMAN, Christopher Gaëtan ,  JANSEN, Koen Karel ,  JI, Jianguo ,  KYM, Philip R. ,  LEFRANCOIS, Jean-Michel ,  MAMMOLITI, Oscar ,  MENET, Christel Jeanne Marie ,  MERAYO, Nuria Merayo ,  NEWSOME, Gregory John Robert ,  PALISSE, Adeline Marie Elise ,  PATEL, Sachin V. ,  PIZZONERO, Mathieu Rafaël ,  SHRESTHA, Anurupa ,  SWIFT, Elizabeth C. ,  TSE, Chris ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61P11/00 ,  G01N33/68

CPC分类号： A61K31/4545 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  G01N33/5023 ,  G01N2800/382

摘要： A corrector agent capable of stabilizing a newly synthesized cystic fibrosis transmembrane conductance regulator (CFTR) protein, useful in the treatment of cystic fibrosis.

公开(公告)号：EP3717471A1

公开(公告)日：2020-10-07

申请号：EP18811769.1

申请日：2018-11-26

申请人： Galapagos NV

发明人： ALVEY, Luke, Jonathan ,  ANNOOT, Denis, Maurice ,  BONNATERRE, Florence, Marie-Emilie ,  BUCHER, Denis ,  DUTHION, Béranger ,  JARY, Hélène, Marie ,  PEIXOTO, Christophe ,  TEMAL-LAIB, Taoues ,  TIRERA, Amynata ,  DESROY, Nicolas

IPC分类号： C07D403/04 ,  C07D471/04 ,  A61K31/437 ,  A61P9/00 ,  A61P37/00

公开(公告)号：EP3359541B1

公开(公告)日：2020-08-05

申请号：EP16788232.3

申请日：2016-10-07

申请人： AbbVie Overseas S.à r.l. ,  Galapagos NV

发明人： AKKARI, Rhalid ,  ALVEY, Luke Jonathan ,  BOCK, Xavier Marie ,  BROWN, Brian S. ,  CLAES, Pieter Isabelle Roger ,  COWART, Marlon D. ,  DE LEMOS, Elsa ,  DESROY, Nicolas ,  DUTHION, Béranger ,  GFESSER, Gregory A. ,  GOSMINI, Romain Luc Marie ,  HOUSSEMAN, Christopher Gaëtan ,  JANSEN, Koen Karel ,  JI, Jianguo ,  KYM, Philip R. ,  LEFRANCOIS, Jean-Michel ,  MAMMOLITI, Oscar ,  MENET, Christel Jeanne Marie ,  MERAYO, Nuria Merayo ,  NEWSOME, Gregory John Robert ,  PALISSE, Adeline Marie Elise ,  PATEL, Sachin V. ,  PIZZONERO, Mathieu Rafaël ,  SHRESTHA, Anurupa ,  SWIFT, Elizabeth C. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing ,  DE BLIECK, Ann

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P11/12 ,  C07D519/00

公开(公告)号：EP3649119A1

公开(公告)日：2020-05-13

申请号：EP18732777.0

申请日：2018-06-21

申请人： Galapagos NV

发明人： MAMMOLITI, Oscar ,  JANSEN, Koen, Karel ,  MENET, Christel, Jeanne, Marie ,  PALISSE, Adeline, Marie, Elise ,  TRICARICO, Giovanni, Alessandro ,  EL BKASSINY, Sandy ,  JAUNET, Alexis, Patrick, Claude ,  ALLART, Brigitte ,  DUTHION, Béranger ,  BREBION, Franck Laurent

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  A61K31/502 ,  A61P29/00