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公开(公告)号：EP2509647B1
公开(公告)日：2016-08-31
申请号：EP10782088.8
申请日：2010-11-08
CPC分类号： A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
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公开(公告)号：EP2509647A1
公开(公告)日：2012-10-17
申请号：EP10782088.8
申请日：2010-11-08
CPC分类号： A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
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公开(公告)号：EP2603171A1
公开(公告)日：2013-06-19
申请号：EP11743759.0
申请日：2011-08-09
发明人： STANKUS, John, J. , STAMBERG, Barbara, E. , KRAMER-BROWN, Pamela, A. , MAGANA, Jesus , BASU, Shubhayu , KHONG, Yuet, Mei , LUDWIG, Florian, N.
IPC分类号： A61F2/24
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds (10) that may be placed within the heart percutaneously. A scaffold assembly may include a layer (22) of biocompatible material detachably secured to a placement rod (36), such that the placement rod may be used to urge the layer of biocompatible material through a catheter (12) to adjacent an area of ischemic tissue. Anchors (28) may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco - elastic foam, around an inflatable member inflated within a ventricle.
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公开(公告)号：EP2509648A1
公开(公告)日：2012-10-17
申请号：EP10782089.6
申请日：2010-11-08
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/608 , A61L2300/61
摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
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公开(公告)号：EP2442840B1
公开(公告)日：2013-10-30
申请号：EP10727273.4
申请日：2010-06-08
发明人： STANKUS, John, J. , TROLLSAS, Mikael , HOSSAINY, Syed , ZHANG, Liangxuan , BERGER, Ed , PACETTI, Stephen, D. , TONER, John, L.
CPC分类号： A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
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公开(公告)号：EP2427227B1
公开(公告)日：2016-08-10
申请号：EP10719554.7
申请日：2010-04-29
CPC分类号： A61L29/16 , A61L29/085 , A61L29/146 , A61L2300/416 , A61L2300/606
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公开(公告)号：EP2442840A2
公开(公告)日：2012-04-25
申请号：EP10727273.4
申请日：2010-06-08
发明人： STANKUS, John, J. , TROLLSAS, Mikael , HOSSAINY, Syed , ZHANG, Liangxuan , BERGER, Ed , PACETTI, Stephen, D. , TONER, John, L.
CPC分类号： A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
摘要： A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
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公开(公告)号：EP2427227A2
公开(公告)日：2012-03-14
申请号：EP10719554.7
申请日：2010-04-29
IPC分类号： A61L29/08
CPC分类号： A61L29/16 , A61L29/085 , A61L29/146 , A61L2300/416 , A61L2300/606
摘要： A coated medical device, such a balloon or stent. The coating includes a therapeutic agent having a thickness of the coating is between about 1.5 to 10 μm and less than 30% of the coating remains on the balloon post delivery to a vessel.
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9.发明公开METHOD AND MEDICAL DEVICE HAVING TISSUE ENGAGING MEMBER FOR DELIVERY OF A THERAPEUTIC AGENT 审中-公开方法和医疗器械与组织手术元在治疗剂释放
公开(公告)号：EP2593049A1
公开(公告)日：2013-05-22
申请号：EP11743898.6
申请日：2011-07-13
IPC分类号： A61F2/84 , A61B17/3207 , A61M25/10
CPC分类号： A61M25/10 , A61F2/958 , A61F2002/9583 , A61F2250/0067 , A61M25/104 , A61M2025/1081 , A61M2025/1086
摘要： Method of delivering a therapeutic agent includes delivering at least a portion of a medical device within a vasculature. The medical device (10) includes a tubular member (12) having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member (30) proximate the distal end of the tubular member, a tissue engaging member (40)? proximate the expandable member, a sheath (50) disposed over the tissue engaging member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The method further includes deploying the tissue engaging member at a select location by displacement of the sheath relative the tissue engaging member, inflating the expandable member to engage the therapeutic agent with a vessel wall, deflating the expandable member, and withdrawing the medical device from the vasculature.
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公开(公告)号：EP2509649A1
公开(公告)日：2012-10-17
申请号：EP10776912.7
申请日：2010-11-08
CPC分类号： A61L29/16 , A61L29/085 , A61L29/141 , A61L2300/416
摘要： A tunable coating formulation is described for a drug delivery balloon comprising a therapeutic agent, an excipient and a plasticizer. The tunable coating includes a first therapeutic agent and a first excipient, and can have a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. The plasticizer in the formulation has a weigh ratio of excipient to plasticizer below 1:0.1.
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