公开(公告)号：EP2424500A1

公开(公告)日：2012-03-07

申请号：EP10718372.5

申请日：2010-04-30

申请人： Abbott Laboratories

发明人： DAVID, Paul ,  FICKES, Michael ,  FISCHER, Cristina ,  HAIGHT, Anthony R. ,  HEEMSTRA, Katherine ,  MARSH, Kennan ,  MAYER, Peter ,  RUBIN, Vitaly ,  SANZGIRI, Yeshwant ,  SCHMITT, Eric ,  TONG, Ping ,  ZHOU, Deliang

IPC分类号： A61K9/00 ,  A61K31/5377 ,  A61K47/00 ,  A61K47/02 ,  A61K47/14 ,  A61K47/20

CPC分类号： A61K31/4965 ,  A61K9/4858 ,  A61K31/5377 ,  A61K47/14 ,  A61K47/24

摘要： An orally deliverable pharmaceutical composition comprises a drug-carrier system having a Bcl-2 family protein inhibitory compound,
e.g ., ABT-263, in solution in a substantially non-aqueous carrier that comprises at least one phospholipid and a pharmaceutically acceptable solubilizing agent. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.