公开(公告)号：EP2424500A1

公开(公告)日：2012-03-07

申请号：EP10718372.5

申请日：2010-04-30

申请人： Abbott Laboratories

发明人： DAVID, Paul ,  FICKES, Michael ,  FISCHER, Cristina ,  HAIGHT, Anthony R. ,  HEEMSTRA, Katherine ,  MARSH, Kennan ,  MAYER, Peter ,  RUBIN, Vitaly ,  SANZGIRI, Yeshwant ,  SCHMITT, Eric ,  TONG, Ping ,  ZHOU, Deliang

IPC分类号： A61K9/00 ,  A61K31/5377 ,  A61K47/00 ,  A61K47/02 ,  A61K47/14 ,  A61K47/20

CPC分类号： A61K31/4965 ,  A61K9/4858 ,  A61K31/5377 ,  A61K47/14 ,  A61K47/24

摘要： An orally deliverable pharmaceutical composition comprises a drug-carrier system having a Bcl-2 family protein inhibitory compound,
e.g ., ABT-263, in solution in a substantially non-aqueous carrier that comprises at least one phospholipid and a pharmaceutically acceptable solubilizing agent. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

公开(公告)号：EP2515883A1

公开(公告)日：2012-10-31

申请号：EP10840069.8

申请日：2010-12-21

申请人： Abbott Laboratories

发明人： TONG, Ping ,  ZHOU, Deliang ,  ZHANG, Geoff G Z ,  HEEMSTRA, Katherine ,  FISCHER, Cristina M. ,  CATRON, Nathaniel ,  SCHMITT, Eric A. ,  SANZGIRI, Yeshwant D.

IPC分类号： A61K9/48 ,  A61K31/655 ,  A61K31/535

CPC分类号： A61K31/5377 ,  A61K9/4858 ,  A61K47/14 ,  A61K47/24

摘要： A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant and (d) at least one sulfur-containing antioxidant. The capsule is useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

公开(公告)号：EP2424849A1

公开(公告)日：2012-03-07

申请号：EP10717392.4

申请日：2010-04-30

申请人： Abbott Laboratories

发明人： BORCHARDT, Thomas ,  BRACKEMYER, Paul ,  CATRON, Nathaniel ,  HENRY, Rodger ,  LOU, Xiaochun ,  RAVN, Matthew ,  ZHANG, Geoff ,  ZHOU, Deliang

IPC分类号： C07D295/155 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D295/155

摘要： ABT-263 bis-HCl and crystalline polymorphs thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

公开(公告)号：EP2424499A1

公开(公告)日：2012-03-07

申请号：EP10717961.6

申请日：2010-04-30

申请人： Abbott Laboratories

发明人： CATRON, Nathaniel ,  FICKES, Michael ,  FISCHER, Cristina ,  HAIGHT, Anthony R. ,  HEEMSTRA, Katherine ,  SANZGIRI, Yeshwant ,  SCHMITT, Eric ,  TONG, Ping ,  ZHANG, Geoff ,  ZHOU, Deliang

IPC分类号： A61K9/00 ,  A61K31/5377 ,  A61K47/00 ,  A61K47/02 ,  A61K47/14 ,  A61K47/20 ,  A61K9/48

CPC分类号： A61K31/5377 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/10 ,  A61K9/4858 ,  A61K47/14 ,  A61K47/183 ,  A61K47/24 ,  A61K47/26

摘要： An orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.