公开(公告)号：EP2515883A1

公开(公告)日：2012-10-31

申请号：EP10840069.8

申请日：2010-12-21

申请人： Abbott Laboratories

发明人： TONG, Ping ,  ZHOU, Deliang ,  ZHANG, Geoff G Z ,  HEEMSTRA, Katherine ,  FISCHER, Cristina M. ,  CATRON, Nathaniel ,  SCHMITT, Eric A. ,  SANZGIRI, Yeshwant D.

IPC分类号： A61K9/48 ,  A61K31/655 ,  A61K31/535

CPC分类号： A61K31/5377 ,  A61K9/4858 ,  A61K47/14 ,  A61K47/24

摘要： A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant and (d) at least one sulfur-containing antioxidant. The capsule is useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.