公开(公告)号：EP2798082B1

公开(公告)日：2017-04-12

申请号：EP12815922.5

申请日：2012-12-20

申请人： Abbott Molecular Inc.

发明人： ZHANG, Ying ,  MORRISON, Larry ,  PESTOVA, Ekaterina ,  SOKOLOVA, Irina

IPC分类号： C12Q1/68

CPC分类号： G01N33/57434 ,  C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/48721 ,  G01N2333/47 ,  C12Q2537/16

摘要： A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

公开(公告)号：EP3400307A1

公开(公告)日：2018-11-14

申请号：EP16766199.0

申请日：2016-09-02

申请人： Abbott Molecular Inc.

发明人： ABRAVAYA, Klara ,  LUCAS, Madhuri ,  PESTOVA, Ekaterina ,  KOCH, Adam ,  WILBER-MADER, Kimberly

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6841 ,  C12Q1/6832 ,  C12Q2523/113 ,  C12Q2527/125

摘要： Disclosed herein are hybridization buffer compositions and hybridization compositions, methods of making the compositions, and methods of using the compositions, such as the hybridization of DNA or RNA sequences by fluorescence in situ hybridization (“FISH”).

公开(公告)号：EP2494076B1

公开(公告)日：2017-11-22

申请号：EP10828825.9

申请日：2010-10-25

申请人： Abbott Molecular Inc.

发明人： PESTOVA, Ekaterina ,  LEGATOR, Mona, Stein ,  LU, Xin ,  SEMIZAROV, Dimitri

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/178

摘要： The methods and compositions described herein address the need for a diagnostic method that can be provided to patients with early stage lung cancer, especially non-small cell lung cancer (NSCLC), to determine whether the patient is at increased risk of poor disease outcome. The methods and compositions thus allow for more informed treatment decisions for the early stage lung cancer patient.

公开(公告)号：EP2798092A2

公开(公告)日：2014-11-05

申请号：EP12863875.6

申请日：2012-12-28

申请人： Abbott Molecular Inc.

发明人： RUSSELL, John, C. ,  PESTOVA, Ekaterina

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6876 ,  C12N15/1093 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/682 ,  C12Q1/6855 ,  C12Q2525/119 ,  C12Q2525/191 ,  C12Q2525/197 ,  C12Q2525/313 ,  C12Q2525/161 ,  C12Q2525/155

摘要： Compositions of nucleic acid hybridization probes for detecting a nucleic acid target sequence and methods for their production are described. In one preferred embodiment, the nucleic acid hybridization probe includes a hybridization domain, an adaptor, a linker, and a signaling domain. The hybridization domain includes a nucleic acid sequence having complementarity to the nucleic acid target sequence. The adaptor is a nucleic acid sequence. The linker includes a moiety having at least one abasic site, such that the moiety blocks extension by an elongating polymerase on a nucleic acid template containing the moiety. The signaling domain comprises a nucleic acid having at least one label or a nucleic acid having at least one nucleic acid domain for binding at least one additional nucleic acid.

公开(公告)号：EP2798082A1

公开(公告)日：2014-11-05

申请号：EP12815922.5

申请日：2012-12-20

申请人： Abbott Molecular Inc.

发明人： ZHANG, Ying ,  MORRISON, Larry ,  PESTOVA, Ekaterina ,  SOKOLOVA, Irina

IPC分类号： C12Q1/68

CPC分类号： G01N33/57434 ,  C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/48721 ,  G01N2333/47 ,  C12Q2537/16

摘要： A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

摘要翻译： 一种检测前列腺癌包括从所述患者接触的前列腺细胞的样品与杂交条件下的一组可检测地标记的探针和确定性采矿染色体异常的在前列腺肿瘤组织中的存在，PIN（上皮内瘤形成），组织学良性组织和 良性前列腺增生（BPH）; 的方法结合免疫荧光和FISH（IF-FISH），以促进染色体异常的评估; 一组探针; 和试剂盒，包括一组探针和指令的用于诊断患者中的前列腺癌。

公开(公告)号：EP2798080A1

公开(公告)日：2014-11-05

申请号：EP12806870.7

申请日：2012-12-20

申请人： Abbott Molecular Inc. ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

发明人： SOKOLOVA, Irina ,  MORRISON, Larry ,  PESTOVA, Ekaterina ,  FRITCHER, Emily, Barr ,  ROBERTS, Lewis ,  GORES, Gregory ,  HALLING, Kevin ,  KIPP, Benjamin

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/112 ,  C12Q2537/16

摘要： A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient.

公开(公告)号：EP2788768A1

公开(公告)日：2014-10-15

申请号：EP12806276.7

申请日：2012-12-10

申请人： Abbott Molecular Inc.

发明人： JEWELL, Susan ,  PESTOVA, Ekaterina ,  LI, Gu ,  SLENK, Carl ,  GERAMI, Pedram

IPC分类号： G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2537/16 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/574

摘要： Methods, probes and kits for diagnosing malignant melanoma and prognosing metastasis thereof in a patient.

摘要翻译： 方法，探针和试剂盒用于诊断恶性黑色素瘤和在其的患者预后转移。

公开(公告)号：EP3272884A2

公开(公告)日：2018-01-24

申请号：EP17190353.7

申请日：2010-10-25

申请人： Abbott Molecular Inc.

发明人： PESTOVA, Ekaterina ,  LEGATOR, Mona, Stein ,  LU, Xin ,  SEMIZAROV, Dimitri

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/178

摘要： The methods and compositions described herein address the need for a diagnostic method that can be provided to patients with early stage lung cancer, especially non-small cell lung cancer (NSCLC), to determine whether the patient is at increased risk of poor disease outcome. The methods and compositions thus allow for more informed treatment decisions for the early stage lung cancer patient.

公开(公告)号：EP3218482A1

公开(公告)日：2017-09-20

申请号：EP15859151.1

申请日：2015-11-11

申请人： Abbott Molecular Inc.

发明人： RUSSELL, John ,  PESTOVA, Ekaterina ,  ADYA, Neeraj

IPC分类号： C12N15/11 ,  C12N15/10

CPC分类号： C12Q1/6876 ,  C12Q1/6816 ,  C12Q1/6832 ,  C12Q2525/155 ,  C12Q2525/191 ,  C12Q2563/107

摘要： The present invention relates to compositions and methods for detection, analysis, and treatment of nucleic acids. In particular, the present invention relates to compositions and methods for generating and using hybridization probes.

摘要翻译： 本发明涉及用于检测，分析和治疗核酸的组合物和方法。 具体而言，本发明涉及用于产生和使用杂交探针的组合物和方法。

公开(公告)号：EP3164504A1

公开(公告)日：2017-05-10

申请号：EP15739712.6

申请日：2015-07-01

申请人： Abbott Molecular Inc.

发明人： ZHANG, Ying ,  PESTOVA, Ekaterina ,  DU, Jing ,  LIU, Ping ,  COLPITTS, Tracey

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Methods of distinguishing and identifying a patient with aggressive/indolent, prostatic adenocarcinoma comprising contacting a sample from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in the sample; sets of probes for use in such methods; and kits comprising a set of probes and instructions for distinguishing or identifying a patient as having aggressive/indolent, prostatic adenocarcinoma.

摘要翻译： 区分和鉴定侵袭性/无痛性前列腺癌患者的方法，包括在杂交条件下将来自患者的样品与一组可检测标记的探针接触，并确定样品中染色体异常的存在; 用于这种方法的探针组; 和包含用于区分或鉴别患有侵袭性/无痛性前列腺癌的一组探针和试剂盒的试剂盒。