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公开(公告)号：EP3668504A1
公开(公告)日：2020-06-24
申请号：EP18846740.1
申请日：2018-08-15
发明人： BRADY, Patrick , BRAJE, Wilfried , DAI, Yujia , DOHERTY, George , GONG, Jane , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , RISI, Roberto , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-Fu , TESKE, Jesse , WANG, Xilu , WENDT, Michael , YU, Yiyun , ZHU, Guidong , PENNING, Thomas , LAI, Chunqiu , KLING, Andreas , POHLKI, Frauke , POTIN, Dominique , GUILLIER, Fabrice
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
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公开(公告)号：EP3668503A1
公开(公告)日：2020-06-24
申请号：EP18845893.9
申请日：2018-08-15
发明人： BRADY, Patrick , BRAJE, Wilfried , DAI, Yujia , DOHERTY, George , GONG, Jane , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , RISI, Roberto , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-fu , TESKE, Jesse , WANG, Xilu , WENDT, Michael , YU, Yiyun , ZHU, Guidong , PENNING, Thomas , LAI, Chunqiu
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
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3.发明公开HEXAHYDRODIAZEPINOQUINOLINES CARRYING A SUBSTITUTED ALKYL RADICAL 有权麻黄碱HITAHYDRODIAZEPINCHINOLINE MIT EINEM SUBSTITUIERTEN ALKYLRADIKAL
公开(公告)号：EP3116874A1
公开(公告)日：2017-01-18
申请号：EP15711464.6
申请日：2015-03-13
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , LAKICS, Viktor , REINGRUBER, Anna , MACK, Helmut , PETER, Raimund , RELO, Ana Lucia , SMYTH, Lynette
IPC分类号： C07D471/04 , A61K31/5513 , A61P25/00
CPC分类号： A61K31/5513 , C07D471/04 , C07D471/18
摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a substituted alkyl radical, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.
摘要翻译： 本发明涉及携带取代的烷基的三环六氢二氮杂喹啉，其制备方法，含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用途 制备用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的药物，用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法，以及制备这种化合物的方法 和组合物。
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公开(公告)号：EP3668502A1
公开(公告)日：2020-06-24
申请号：EP18845598.4
申请日：2018-08-15
申请人： AbbVie Inc. , Abbvie Deutschland GmbH & Co. KG , Braje, Wilfried , Doherty, George , Jantos, Katja , Ji, Cheng , Judd, Andrew , Kunzer, Aaron , Mastracchio, Anthony , Song, Xiaohong , Souers, Andrew , Sullivan, Gerard , Tao, Zhi-Fu , Lai, Chunqiu , Kling, Andreas , Pohlki, Frauke , Teske, Jesse , Wendt, Michael , Brady, Patrick , Wang, Xilu , Penning, Thomas , Michaelides, Michael
发明人： BRAJE, Wilfried , DOHERTY, George , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-Fu , LAI, Chunqui , KLING, Andreas , POHLKI, Frauke , TESKE, Jessc , WENDT, Michael , BRADY, Patrick , WANG, Xilu , PENNING, Thomas , MICHAELIDES, Michael
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
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5.发明公开
公开(公告)号：EP3408258A1
公开(公告)日：2018-12-05
申请号：EP17701874.4
申请日：2017-01-27
发明人： BRAJE, Wilfried , BRITZE, Katarina , DIETRICH, Justin, D. , JOLIT, Anais , KASCHEL, Johannes , KLEE, Johanna , LINDNER, Tanja
IPC分类号： C07D215/227 , C07B37/04 , C07B43/04 , C07B43/06 , C07D405/04 , C07D239/26 , C07D409/04 , C07F5/02 , C07D307/36
CPC分类号： C07B63/04 , C07B37/04 , C07B43/04 , C07B43/06 , C07C41/46 , C07C67/62 , C07C209/90 , C07C213/10 , C07C231/22 , C07C253/32 , C07C269/08 , C07C273/189 , C07C303/42 , C07C319/26 , C07D205/04 , C07D207/34 , C07D209/08 , C07D209/48 , C07D211/06 , C07D213/74 , C07D215/227 , C07D239/26 , C07D239/42 , C07D307/36 , C07D307/81 , C07D311/58 , C07D405/04 , C07D409/04 , C07D471/04 , C07D495/04 , C07F5/02 , C07F5/025
摘要： The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.
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公开(公告)号：EP3116873B1
公开(公告)日：2018-02-28
申请号：EP15711463.8
申请日：2015-03-13
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , KOOLMAN, Hannes , LAKICS, Viktor , REINGRUBER, Anna , MACK, Helmut , PETER, Raimund , RELO, Ana Lucia , WANG, Jincheng , ZHAO, Xiaona
IPC分类号： C07D471/04 , A61K31/5513 , A61P25/00
CPC分类号： C07D471/06 , C07D471/04
摘要： The present invention relates to compound of formula (I) as tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, useful for modulating the 5-HT2C receptor and preventing and/or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor. The present invention also relates to methods for producing compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for preventing or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor by administering compounds of formula (1) or pharmaceutical compositions thereof.
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7.发明公开FUSED HETEROCYCLIC OR CARBOCYCLIC COMPOUNDS CARRYING A SUBSTITUTED CYCLOALIPHATIC RADICAL AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 审中-公开带有取代的环脂肪酸自由基的稠合杂环或碳环化合物及其用于治疗血管收缩素相关疾病的用途
公开(公告)号：EP3191459A1
公开(公告)日：2017-07-19
申请号：EP15759450.8
申请日：2015-09-04
发明人： BRAJE, Wilfried , FROGGETT, Jayne , GENESTE, Hervé , HORNBERGER, Wilfried , JANTOS, Katja , KLING, Andreas , VAN GAALEN, Marcel
IPC分类号： C07D239/91
CPC分类号： C07D239/91 , C07D401/12 , C07D403/12 , C07D455/02 , C07D491/107
摘要： The present invention relates to novel fused heterocyclic or carbocyclic compounds of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising these compounds, and to their use for the treatment of vasopressin-related disorders.
摘要翻译： 本发明涉及新的式I的稠合杂环或碳环化合物，其中变量如权利要求和描述中所定义。 本发明还涉及包含这些化合物的药物组合物，并涉及它们用于治疗加压素相关病症的用途。
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8.发明公开
公开(公告)号：EP2895485A1
公开(公告)日：2015-07-22
申请号：EP13762483.9
申请日：2013-09-13
发明人： KOOLMAN, Hannes , BRAJE, Wilfried , MACK, Helmut , HAUPT, Andreas , RELO, Ana Lucia , DRESCHER, Karla , BAKKER, Margaretha Henrica Maria , LAKICS, Viktor , HOFT, Carolin , XU, Ruxu , ZHAO, Xiaona
IPC分类号： C07D471/06 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06 , C07D487/16
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
摘要翻译： 本发明涉及三环喹啉和喹喔啉衍生物，涉及含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备预防或治疗 对5-HT 2C受体的调节作出反应的病症和障碍，以及用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法。
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公开(公告)号：EP3988555A1
公开(公告)日：2022-04-27
申请号：EP21197248.4
申请日：2018-08-15
发明人： BRAJE, Wilfried , DOHERTY, George , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-Fu , TESKE, Jesse , WANG, Xilu , WENDT, Michael , PENNING, Thomas , LAI, Chunqiu , KLING, Andreas , POHKLI, Frauke
IPC分类号： C07D515/22 , A61K31/395 , A61P35/00
摘要： The present disclosure provides for compounds of formula (I)
wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , A 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).-
公开(公告)号：EP3636651A1
公开(公告)日：2020-04-15
申请号：EP19212082.2
申请日：2016-11-24
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , LAKICS, Viktor , MACK, Helmut , OELLIEN, Frank , PETER, Raimund , RELO, Ana Lucia
IPC分类号： C07D498/04 , C07D498/14 , A61K31/553 , A61P25/24
摘要： The present invention relates to compound of formula (I)
wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT 2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT 2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT 2C receptor.
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