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1.发明授权Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor 有权针对肿瘤坏死因子-α的单域抗体及其应用
公开(公告)号：EP2390268B1
公开(公告)日：2017-11-01
申请号：EP10182757.4
申请日：2003-11-07
申请人： Ablynx N.V.
发明人： Silence, Karen , Lauwereys, Marc , De Haard, Hans
IPC分类号： C07K16/28 , C07K16/18 , C07K16/46 , A61K39/395 , C12N15/13 , G01N33/577 , A61P37/06 , A61P19/02
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/31
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公开(公告)号：EP2301967A2
公开(公告)日：2011-03-30
申请号：EP10178270.4
申请日：2003-11-07
申请人： Ablynx N.V.
IPC分类号： C07K16/18 , A61K39/395 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/31
摘要： The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention furthe relates to anti-lgE therapeutic molecules.
摘要翻译： 本发明涉及适用于通过使用来源于骆驼科抗体的VHH多肽经口，舌下，局部，静脉内，皮下，鼻，阴道，直肠或吸入施用蛋白质治疗分子以避免失活的方法。 本发明还涉及所述治疗分子。 本发明还涉及将治疗分子递送至细胞内部的方法。 本发明还涉及抗IgE治疗分子。
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3.发明公开Method of administering therapeutic polypeptides, and polypeptides therefor 审中-公开一种用于这种治疗性多肽和多肽的给药方法
公开(公告)号：EP2267032A2
公开(公告)日：2010-12-29
申请号：EP10178278.7
申请日：2003-11-07
申请人： Ablynx N.V.
IPC分类号： C07K16/42 , A61K39/395 , A61P27/02 , A61P29/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2863 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/42 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of ceils. The invention furthe relates to anti-lgE therapeutic molecules.
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公开(公告)号：EP2316852B1
公开(公告)日：2014-03-05
申请号：EP10183379.6
申请日：2003-11-07
申请人： Ablynx N.V.
发明人： Silence, Karen , Lauwereys, Marc , Dreier, Torsten
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/31
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公开(公告)号：EP2316852A1
公开(公告)日：2011-05-04
申请号：EP10183379.6
申请日：2003-11-07
申请人： Ablynx N.V.
发明人： Silence, Karen , Lauwereys, Marc , Dreier, Torsten
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/31
摘要： The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention furthe relates to anti-IgE therapeutic molecules.
摘要翻译： 本发明涉及一种适用于通过使用源自骆驼科抗体的VHH多肽来口服，舌下，局部，静脉内，皮下，经鼻，阴道，直肠或吸入施用蛋白质治疗分子的方法，以避免失活。 本发明还涉及所述治疗分子。 本发明还提供了一种将治疗分子递送至细胞内部的方法。 本发明涉及抗IgE治疗分子。
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公开(公告)号：EP2258392A1
公开(公告)日：2010-12-08
申请号：EP10178264.7
申请日：2003-11-07
申请人： Ablynx N.V.
IPC分类号： A61K39/395 , C07K16/18 , A61P11/06 , A61P35/00 , A61P31/16
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/31
摘要： The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention furthe relates to anti-lgE therapeutic molecules.
摘要翻译： 本发明涉及一种适用于通过使用源自骆驼科抗体的VHH多肽来口服，舌下，局部，静脉内，皮下，经鼻，阴道，直肠或吸入施用蛋白质治疗分子的方法，以避免失活。 本发明还涉及所述治疗分子。 本发明还提供了一种将治疗分子递送至细胞内部的方法。 本发明涉及抗lgE治疗分子。
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7.发明公开SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST TUMOUR NECROSIS FACTOR-ALPHA AND USES THEREFOR 审中-公开用于抗肿瘤坏死因子α的单域抗体及其用途
公开(公告)号：EP3299393A1
公开(公告)日：2018-03-28
申请号：EP17186411.9
申请日：2003-11-07
申请人： Ablynx N.V.
发明人： Silence, Karen , Lauwereys, Marc , De Haard, Hans
IPC分类号： C07K16/42 , C07K16/24 , C07K16/30 , C07K16/12 , C07K16/10 , C07K16/40 , C07K16/28 , C12N15/13 , A61K39/395 , A61P11/06 , A61P35/00 , A61P31/06 , A61P31/16
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/31
摘要： The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention furthe relates to anti-IgE therapeutic molecules.
摘要翻译： 本发明涉及适用于通过使用来源于骆驼科抗体的VHH多肽经口，舌下，局部，静脉内，皮下，鼻，阴道，直肠或吸入施用蛋白质治疗分子以避免失活的方法。 本发明还涉及所述治疗分子。 本发明还涉及将治疗分子递送至细胞内部的方法。 本发明还涉及抗IgE治疗分子。
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8.发明公开
公开(公告)号：EP2267032A3
公开(公告)日：2011-11-09
申请号：EP10178278.7
申请日：2003-11-07
申请人： Ablynx N.V.
IPC分类号： C07K16/42 , C07K16/24 , C07K16/30 , C07K16/12 , C07K16/10 , C07K16/40 , C07K16/28 , C12N15/13 , A61K39/395 , A61P11/06 , A61P35/00 , A61P31/06 , A61P31/16 , A61P27/02 , A61P29/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2863 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/42 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to single domain anti-lgE antibodies. Polypeptide constructs which contain at least two single domain antibodies one of the antibodies being an anti-IgE antibody. Use of the antibodies in the treatment of allergy, inflammatory related disorders and ocular disorders.
摘要翻译： 本发明涉及单域抗IgE抗体。 含有至少两个单结构域抗体的多肽构建体，其中一个抗体是抗IgE抗体。 抗体在治疗变态反应，炎症相关疾病和眼部疾病中的用途。
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9.发明公开Method of administering therapeutic polypeptides, and polypeptides therefor 审中-公开Verfahren zur Verabreichung therapeutischer Polypeptide und Polypeptidedafür
公开(公告)号：EP2267027A3
公开(公告)日：2011-07-20
申请号：EP10178260.5
申请日：2003-11-07
申请人： Ablynx N.V.
IPC分类号： C07K16/42 , C07K16/24 , C07K16/30 , C07K16/12 , C07K16/10 , C07K16/40 , C07K16/28 , C12N15/13 , A61K39/395 , A61P11/06 , A61P35/00 , A61P31/06 , A61P31/16 , A61P27/02 , C07K16/18
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2863 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/42 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention furthe relates to anti-lgE therapeutic molecules.
摘要翻译： 本发明涉及单结构域抗-IgE抗体。 含有至少两个单结构域抗体的多肽构建体，一种抗体是抗IgE抗体。 使用抗体治疗过敏，炎症相关疾病和眼部疾病。
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公开(公告)号：EP2301967A3
公开(公告)日：2011-07-13
申请号：EP10178270.4
申请日：2003-11-07
申请人： Ablynx N.V.
IPC分类号： C07K16/42 , C07K16/24 , C07K16/30 , C07K16/12 , C07K16/10 , C07K16/40 , C07K16/28 , C12N15/13 , A61K39/395 , A61P11/06 , A61P35/00 , A61P31/06 , A61P31/16
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/31
摘要： The invention relates to a composition for administering single domain antibodies nasally or by inhalation so as to avoid inactivation, e.g. by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to compositions comprising single domain antibodies against TNF, EGFR, IgE or MMP-12. Finally, the invention relates to an inhalation device comprising the single domain antibody.
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