专利检索 ap:("Acadia Pharmaceuticals Inc.") AND inv:"WEISSMAN, Jacques Thomas" 第 1 页

1.

发明授权
HIGH THROUGHPUT FUNCTIONAL ASSAY FOR G-PROTEIN COUPLED RECEPTORS USING A RAP-RAS CHIMERIC PROTEIN 有权
标题翻译：功能测定HIGH THROUGHPUT用于与嵌合RAP-Ras蛋白的G蛋白偶联受体

公开(公告)号：EP1692165B1

公开(公告)日：2009-01-07

申请号：EP04810260.2

申请日：2004-11-02

申请人： Acadia Pharmaceuticals Inc.

发明人： BURSTEIN, Ethan S. , PIU, Fabrice , MA, Jian-Nong , WEISSMAN, Jacques Thomas , WEINER, David, M. , SCULLY, Audra, L. , NASH, Norman , SPALDING, Tracy , CURRIER, Erika

IPC分类号： C07K14/47 , G01N33/50 , C12N15/10 , C12Q1/68

CPC分类号： C07K14/82 , C12N9/16 , C12N15/1086 , G01N33/76

摘要： Disclosed herein are methods for enabling or improving functional assays of G-protein coupled receptors through the use of co-expression of helper genes. In some cases, chimeras linking the regulatory domain of the rap1B protein to the effector region of the ras oncogene are used in conjuction with existing functional assays for cellular proliferation. Furthermore, overexpression of other genes can further augment the enabling properties of ras/rap chimeras.