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公开(公告)号：EP1907347A2
公开(公告)日：2008-04-09
申请号：EP06787368.7
申请日：2006-07-12
发明人： OLSSON, Roger , PIU, Fabrice , GUNDERSEN, Birgitte
IPC分类号： C07C63/06 , C07D277/34 , C07D233/60 , C07D249/14
CPC分类号： C07C243/38 , C07C63/06 , C07C255/14 , C07C259/10 , C07C311/51 , C07C2601/02 , C07C2601/18 , C07D213/30 , C07D213/40 , C07D213/75 , C07D233/54 , C07D239/26 , C07D277/34 , C07D295/155 , C07D307/42 , C07D307/52
摘要： Disclosed herein are novel compounds with activity at RARβ 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders such as memory deficits and schizophrenia, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, inflammatory disorders such as psoriasis and rheumatoid arthritis, eye disorders and depression.
摘要翻译： 本文公开了对RARβ2受体具有活性的新化合物。 还公开了这些化合物用于治疗或缓解癌症症状，神经障碍如记忆缺陷和精神分裂症，神经退行性病症如帕金森病和阿尔茨海默病，炎性病症如牛皮癣和类风湿性关节炎，眼部病症和抑郁症的用途。
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2.发明授权HIGH THROUGHPUT FUNCTIONAL ASSAY FOR G-PROTEIN COUPLED RECEPTORS USING A RAP-RAS CHIMERIC PROTEIN 有权功能测定HIGH THROUGHPUT用于与嵌合RAP-Ras蛋白的G蛋白偶联受体
公开(公告)号：EP1692165B1
公开(公告)日：2009-01-07
申请号：EP04810260.2
申请日：2004-11-02
发明人： BURSTEIN, Ethan S. , PIU, Fabrice , MA, Jian-Nong , WEISSMAN, Jacques Thomas , WEINER, David, M. , SCULLY, Audra, L. , NASH, Norman , SPALDING, Tracy , CURRIER, Erika
CPC分类号： C07K14/82 , C12N9/16 , C12N15/1086 , G01N33/76
摘要： Disclosed herein are methods for enabling or improving functional assays of G-protein coupled receptors through the use of co-expression of helper genes. In some cases, chimeras linking the regulatory domain of the rap1B protein to the effector region of the ras oncogene are used in conjuction with existing functional assays for cellular proliferation. Furthermore, overexpression of other genes can further augment the enabling properties of ras/rap chimeras.
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3.发明公开HIGH TROUGHPUT FUNCTIONAL ASSAY FOR G-PROTEIN COUPLED RECEPTORS USING A RAP-RAS CHIMERIC PROTEIN 有权功能测定HIGH THROUGHPUT用于与嵌合RAP-Ras蛋白的G蛋白偶联受体
公开(公告)号：EP1692165A1
公开(公告)日：2006-08-23
申请号：EP04810260.2
申请日：2004-11-02
发明人： BURSTEIN, Ethan S. , PIU, Fabrice , MA, Jian-Nong , Weissman, Jacques Thomas , WEINER, David, M. , SCULLY, Audra, L. , NASH, Norman , SPALDING, Tracy , Currier, Erika
CPC分类号： C07K14/82 , C12N9/16 , C12N15/1086 , G01N33/76
摘要： Disclosed herein are methods for enabling or improving functional assays of G-protein coupled receptors through the use of co-expression of helper genes. In some cases, chimeras linking the regulatory domain of the rap1B protein to the effector region of the ras oncogene are used in conjuction with existing functional assays for cellular proliferation. Furthermore, overexpression of other genes can further augment the enabling properties of ras/rap chimeras.
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4.发明公开
公开(公告)号：EP1747182A2
公开(公告)日：2007-01-31
申请号：EP05742664.5
申请日：2005-05-03
CPC分类号： C07C43/23 , A61K31/05 , A61K31/055 , C07C17/263 , C07C17/2632 , C07C37/055 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/30 , C07C49/753 , C07C59/72 , C07C65/26 , C07C2601/14 , C07C2601/18 , C07D309/12 , C07C25/18
摘要： Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
摘要翻译： 本文公开了新的二苯基化合物和使用各种二苯基化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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公开(公告)号：EP1812798A2
公开(公告)日：2007-08-01
申请号：EP05824685.1
申请日：2005-11-18
发明人： PIU, Fabrice
CPC分类号： G01N33/6875 , G01N33/502 , G01N33/74 , G01N33/78 , G01N2500/00 , G01N2500/04 , G01N2500/10
摘要： A method and kit developed to identify substances that act as ligands, corepressors, coactivators, agonist and antagonists for cloned nuclear hormone receptors, as well as a test kit for use in the methods is provided herein. More specifically, the method involves expressing a nuclear hormone receptor, receptor heterodimer, and/or receptor homodimer, DNA encoding one or more signaling molecules and DNA encoding a marker, incubating the cells with a test substance, and identifying whether the test substance interacts with the receptor quantitatively or qualitatively by identifying the amount of marker and/or the proliferation of the cells.
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