公开(公告)号：EP3004082A1

公开(公告)日：2016-04-13

申请号：EP14730591.6

申请日：2014-05-28

申请人： Actelion Pharmaceuticals Ltd.

发明人： FRETZ, Heinz ,  GUERRY, Philippe ,  KIMMERLIN, Thierry ,  LEHEMBRE, Francois ,  POTHIER, Julien ,  SIENDT, Hervé ,  VALDENAIRE, Anja

IPC分类号： C07D405/12 ,  C07D211/56 ,  A61K31/455

CPC分类号： C07D217/04 ,  C07D211/56 ,  C07D217/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

摘要： The present invention relates to derivatives of formula (I) wherein (R1)n, R2a, R2b, R3a, R3b, R4, L1, L2, X, Y and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

摘要翻译： 本发明涉及式（I）的衍生物，其中（R1）n，R2a，R2b，R3a，R3b，R4，L1，L2，X，Y和Ar1如说明书所述，其制备方法涉及药学上可接受的 以及它们作为药物的用途，含有一种或多种式（I）化合物的药物组合物，特别是其作为CXCR7受体调节剂的用途。

公开(公告)号：EP2864315A2

公开(公告)日：2015-04-29

申请号：EP13759008.9

申请日：2013-06-21

申请人： Actelion Pharmaceuticals Ltd.

发明人： FRETZ, Heinz ,  GUDE, Markus ,  GUERRY, Philippe ,  KIMMERLIN, Thierry ,  LEHEMBRE, Francois ,  PFEIFER, Thomas ,  VALDENAIRE, Anja

IPC分类号： C07D401/06 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/4545 ,  C07D211/62 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

摘要： The present invention relates to 1-[m-Carboxamido(hetero)aryl-methyl]-piperidine-4-carboxamide derivatives of formula (I) wherein X, Ar1, R1, R2, R3, R4, R5 and p are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

公开(公告)号：EP3227263A1

公开(公告)日：2017-10-11

申请号：EP15801467.0

申请日：2015-11-30

申请人： Actelion Pharmaceuticals Ltd

发明人： GUERRY, Philippe ,  LEHEMBRE, Francois ,  POTHIER, Julien ,  SIENDT, Hervé

IPC分类号： C07D223/16 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  C07D243/14 ,  C07D267/14

CPC分类号： C07D417/12 ,  A61K31/553 ,  A61K45/06 ,  C07D223/16 ,  C07D243/14 ,  C07D267/14 ,  C07D405/12 ,  C07D405/14

摘要： wherein (R1)n, ring (A), Y1, Y2, X, R4, L1, L2, and A1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

摘要翻译： 本发明涉及式（I）的衍生物，其中（R 1）n，环（A），Y 1，Y 2，X，R 4，L 1，L 2和Ar 1如描述中所述， 它们的制备，药学上可接受的盐，以及它们作为药物的用途，含有一种或多种式（I）化合物的药物组合物，特别是它们作为CXCR7受体调节剂的用途。