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公开(公告)号：EP3004082A1
公开(公告)日：2016-04-13
申请号：EP14730591.6
申请日：2014-05-28
发明人： FRETZ, Heinz , GUERRY, Philippe , KIMMERLIN, Thierry , LEHEMBRE, Francois , POTHIER, Julien , SIENDT, Hervé , VALDENAIRE, Anja
IPC分类号： C07D405/12 , C07D211/56 , A61K31/455
CPC分类号： C07D217/04 , C07D211/56 , C07D217/06 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to derivatives of formula (I) wherein (R1)n, R2a, R2b, R3a, R3b, R4, L1, L2, X, Y and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
摘要翻译： 本发明涉及式（I）的衍生物，其中（R1）n，R2a，R2b，R3a，R3b，R4，L1，L2，X，Y和Ar1如说明书所述，其制备方法涉及药学上可接受的 以及它们作为药物的用途，含有一种或多种式（I）化合物的药物组合物，特别是其作为CXCR7受体调节剂的用途。
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2.发明授权(3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES 有权（3-氨基-1,2,3,4-四氢-9H-咔唑-9-基）-ESSIGSÄUREDERIVATE
公开(公告)号：EP2051962B1
公开(公告)日：2011-10-26
申请号：EP07805287.5
申请日：2007-08-02
发明人： FRETZ, Heinz , POTHIER, Julien , RISCH, Philippe
IPC分类号： C07D209/88
CPC分类号： C07D209/88
摘要： The present invention relates to (3-amino-l,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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公开(公告)号：EP2242743A1
公开(公告)日：2010-10-27
申请号：EP08862120.6
申请日：2008-12-12
发明人： BUR, Daniel , CORMINBOEUF, Olivier , CREN, Sylvaine , FRETZ, Heinz , GRISOSTOMI, Corinna , LEROY, Xavier , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia
IPC分类号： C07D231/40 , C07D411/12 , C07D413/12 , A61K31/4155 , A61P31/18
CPC分类号： C07D231/40 , C07D411/12 , C07D413/12
摘要： The invention relates to aminopyrazole derivatives of formula (I), (I) wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
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4.发明公开(3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES 有权（3-氨基-1,2,3,4-四氢-9H-咔唑-9-基） - 乙酸的衍生物
公开(公告)号：EP2051962A1
公开(公告)日：2009-04-29
申请号：EP07805287.5
申请日：2007-08-02
发明人： FRETZ, Heinz , POTHIER, Julien , RISCH, Philippe
IPC分类号： C07D209/88
CPC分类号： C07D209/88
摘要： The present invention relates to (3-amino-l,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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公开(公告)号：EP3227263A1
公开(公告)日：2017-10-11
申请号：EP15801467.0
申请日：2015-11-30
IPC分类号： C07D223/16 , A61K31/55 , A61K31/5513 , A61K31/553 , C07D243/14 , C07D267/14
CPC分类号： C07D417/12 , A61K31/553 , A61K45/06 , C07D223/16 , C07D243/14 , C07D267/14 , C07D405/12 , C07D405/14
摘要： wherein (R1)n, ring (A), Y1, Y2, X, R4, L1, L2, and A1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
摘要翻译： 本发明涉及式（I）的衍生物，其中（R 1）n，环（A），Y 1，Y 2，X，R 4，L 1，L 2和Ar 1如描述中所述， 它们的制备，药学上可接受的盐，以及它们作为药物的用途，含有一种或多种式（I）化合物的药物组合物，特别是它们作为CXCR7受体调节剂的用途。
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公开(公告)号：EP2242743B1
公开(公告)日：2013-08-21
申请号：EP08862120.6
申请日：2008-12-12
发明人： BUR, Daniel , CORMINBOEUF, Olivier , CREN, Sylvaine , FRETZ, Heinz , GRISOSTOMI, Corinna , LEROY, Xavier , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia
IPC分类号： C07D231/40 , C07D411/12 , C07D413/12 , A61K31/4155 , A61P31/18
CPC分类号： C07D231/40 , C07D411/12 , C07D413/12
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7.发明授权1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权1-苯基 - 取代的杂环衍生物及其前列腺素D2受体的调节剂
公开(公告)号：EP2590944B1
公开(公告)日：2015-09-30
申请号：EP11752340.7
申请日：2011-07-04
发明人： AISSAOUI, Hamed , BOSS, Christoph , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia , RISCH, Philippe , SIEGRIST, Romain , FRETZ, Heinz
IPC分类号： C07D209/44 , C07D217/16 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , A61K31/4035 , A61K31/472
CPC分类号： C07D487/04 , A61K31/4035 , A61K31/472 , C07D209/44 , C07D217/16 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
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8.发明公开1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权1-苯基 - 取代的杂环衍生物及其前列腺素D2受体的调节剂
公开(公告)号：EP2590944A1
公开(公告)日：2013-05-15
申请号：EP11752340.7
申请日：2011-07-04
发明人： AISSAOUI, Hamed , BOSS, Christoph , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia , RISCH, Philippe , SIEGRIST, Romain , FRETZ, Heinz
IPC分类号： C07D209/44 , C07D217/16 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , A61K31/4035 , A61K31/472
CPC分类号： C07D487/04 , A61K31/4035 , A61K31/472 , C07D209/44 , C07D217/16 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
摘要： 302 Abstract The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), O Y R 5 R 6 N R 2 R 3 R 4 X Z R 1 R 7 R 7 R 10 n (I) 5 wherein X, Y, Z, n, R 1, R 2, R 3, R 4, R 5, R 6, R 7 and R 10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation. 10
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9.发明公开2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS 审中-公开2 - 硫烷基 - 苯并咪唑-1-基 - 乙酸衍生物作为CRTH2拮抗剂
公开(公告)号：EP1784182A1
公开(公告)日：2007-05-16
申请号：EP05778612.1
申请日：2005-08-23
发明人： FRETZ, Heinz , HILPERT, Kurt , RIEDERER, Markus , STEGER, Matthias , POTHIER, Julien , GUDE, Markus
IPC分类号： A61K31/4184 , A61K31/425 , A61K31/4439 , A61K31/445 , A61K31/4709 , A61P1/00 , A61P1/04 , A61P5/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P27/02
摘要： The invention relates to 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives and their use as potent 'chemoattractant receptor-homologous molecule expressed on Th2 cells' antagonists in the treatment of prostaglandin mediated diseases, to pharmaceutical compositions containing these derivatives and to processes for their preparation.
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