公开(公告)号：EP2719449A1

公开(公告)日：2014-04-16

申请号：EP13192675.0

申请日：2012-05-01

申请人： Advanced Liquid Logic, Inc.

发明人： Bort, Donovan ,  Graham, Carrie ,  Pamula, Vamsee ,  Pollack, Michael ,  Sista, Ramakrishna ,  Srinivasan, Vijay

IPC分类号： B01F13/00 ,  B01L3/00

CPC分类号： G01N27/44791 ,  B01F1/0027 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2001/0055 ,  B01F2215/0037 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0487 ,  B81B1/004

摘要： A droplet actuator (110) comprising: one or more substrates (114, 116) arranged to form a droplet operations gap, the droplet operations gap comprising a region of gap height transition in which the gap height of the droplet operations gap transitions from a first gap height to a second gap height; and electrodes associated with the one or more substrates arranged for conducting droplet operations, the electrodes comprising a transition electrode which traverses the region of gap height transition. The electrodes may comprise electrowetting electrodes. The transition electrode may be flanked by first and second sets of electrodes having first and second footprint areas. The first footprint area may be greater than the second footprint area. The first set of electrodes may be arranged in a region of greater gap height and the second set of electrodes may be arranged in the region of lesser gap height.

摘要翻译： 液滴致动器（110）包括：布置成形成液滴操作间隙的一个或多个基板（114,116），所述液滴操作间隙包括间隙高度过渡区域，其中液滴操作间隙的间隙高度从第一 间隙高度到第二间隙高度; 以及与布置用于进行液滴操作的所述一个或多个基板相关联的电极，所述电极包括穿过间隙高度转变区域的过渡电极。 电极可以包括电润湿电极。 过渡电极可以由具有第一和第二覆盖区域的第一和第二组电极的侧面。 第一个足迹区域可能大于第二个足迹区域。 第一组电极可以布置在较大间隙高度的区域中，并且第二组电极可以布置在较小间隙高度的区域中。

公开(公告)号：EP2570812A3

公开(公告)日：2013-12-11

申请号：EP12191032.7

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

公开(公告)号：EP2570812B1

公开(公告)日：2018-07-18

申请号：EP12191032.7

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

公开(公告)号：EP2570811A3

公开(公告)日：2013-12-11

申请号：EP12191029.3

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A droplet actuator device (600) comprises: an array of electrodes (622) on a substrate (614) configured for conducting one or more droplet operations; a magnet (638) that exerts a magnetic field on a droplet (634) positioned on a first set of one or more of the electrodes (622); and a magnetic shield (642) that shields a droplet (634) positioned on a second set of one or more of the electrodes (622) from the magnetic field. A method of conducting a droplet operation using the device comprises: positioning a first droplet (634) comprising one or more magnetically responsive beads on one or more electrodes (622) from the first set, so that the beads are attracted by the magnetic field; positioning a second droplet comprising one or more magnetically responsive beads on one or more electrodes from the second set, so that the beads are not attracted by the magnetic field; and conducting a droplet operation on the first droplet and/or the second droplet.

公开(公告)号：EP2570812A2

公开(公告)日：2013-03-20

申请号：EP12191032.7

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00 ,  C12M1/12

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

摘要翻译： 一种组装液滴致动器组件（1400）的方法包括：将包括发射影响存在于液滴致动器组件中的液滴的电场（1438）的电极的衬底（1434）附接到安装结构（1410）;以及磁体组件 1420），其被配置为容纳发射影响存在于所述液滴致动器组件中的磁响应珠的磁场的磁体（1428）。 衬底（1434）和磁体组件（1420）中的至少一个可移除地附接到安装结构（1410）。 附接衬底（1434）可以进一步包括从被配置为附接到安装结构（1410）并包括不同电场发射特性的多个衬底（1434）中选择衬底，和/或从磁体组件（1420）选择 在多个磁性组件（1420）中，每个磁体组件被配置成附接到安装结构（1410）并且包括不同的磁体属性。

公开(公告)号：EP2570811B1

公开(公告)日：2014-11-26

申请号：EP12191029.3

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A method of assembling a droplet actuator assembly (1400) comprises: attaching to a mount structure (1410) a substrate (1434) including an electrode emitting an electric field (1438) affecting a droplet present in the droplet actuator assembly and a magnet assembly (1420) configured to accommodate a magnet (1428) emitting a magnetic field affecting a magnetically responsive bead present in the droplet actuator assembly. At least one of the substrate (1434) and the magnet assembly (1420) are removably attached to the mount structure (1410). Attaching the substrate (1434) may further comprise selecting the substrate from among a plurality of substrates (1434) configured to attach to the mount structure (1410) and including different electric field emission characteristics, and/or selecting the magnet assembly (1420) from among a plurality of magnetic assemblies (1420), each magnet assembly configured to attach to the mount structure (1410) and including different magnet properties.

公开(公告)号：EP2573562A3

公开(公告)日：2013-10-30

申请号：EP12191030.1

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N33/00

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A droplet actuator device comprises magnet sets and electrode sets, wherein: each electrode set comprises one or more electrodes associated with a substrate. Two or more electrode sets are arranged to form an array of electrodes; and configured for conducting one or more droplet operations. Each magnet set comprises one or more magnets. Each magnet set is arranged in a relationship with an electrode set such that magnetic field(s) exerted by the magnet set restrict mobility of magnetically responsive particles to a locus which is proximate to the electrode set. Each magnet set is arranged in relationship to its adjacent magnet set(s), which relationship a polar opposite to the polar orientation of the adjacent magnet set.

摘要翻译： 液滴致动器装置包括磁体组和电极组，其中：每个电极组包括与基底相关联的一个或多个电极。 布置两个或更多个电极组以形成电极阵列; 并被配置用于进行一个或多个液滴操作。 每个磁体组包括一个或多个磁体。 每个磁体组以与电极组相关的关系布置，使得由磁体组施加的磁场限制磁响应粒子的移动性到接近电极组的轨迹。 每个磁体组相对于其相邻的磁体组排列，该磁体组的极性与相邻磁体组的极性方向相反。

公开(公告)号：EP2573562A2

公开(公告)日：2013-03-27

申请号：EP12191030.1

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00 ,  C12M1/12

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A droplet actuator device comprises magnet sets and electrode sets, wherein: each electrode set comprises one or more electrodes associated with a substrate. Two or more electrode sets are arranged to form an array of electrodes; and configured for conducting one or more droplet operations. Each magnet set comprises one or more magnets. Each magnet set is arranged in a relationship with an electrode set such that magnetic field(s) exerted by the magnet set restrict mobility of magnetically responsive particles to a locus which is proximate to the electrode set. Each magnet set is arranged in relationship to its adjacent magnet set(s), which relationship a polar opposite to the polar orientation of the adjacent magnet set.

摘要翻译： 液滴致动器装置包括磁体组和电极组，其中：每个电极组包括与衬底相关联的一个或多个电极。 布置两个或更多个电极组以形成电极阵列; 并且被配置为进行一个或多个液滴操作。 每个磁体组包括一个或多个磁体。 每个磁体组与电极组相关联地设置，使得由磁体组施加的磁场将磁响应粒子的移动性限制在靠近电极组的轨迹。 每个磁体组与其相邻的磁体组相关地布置，该磁体集合与相邻磁体组的极坐标极性相反。

公开(公告)号：EP2570811A2

公开(公告)日：2013-03-20

申请号：EP12191029.3

申请日：2008-02-11

申请人： Advanced Liquid Logic, Inc.

发明人： Sista, Ramakrishna ,  Pamula, Vamsee K. ,  Srinivasan, Vijay ,  Eckhardt, Allen E. ,  Pollack, Michael G.

IPC分类号： G01N33/543 ,  B01L3/00 ,  C12M1/12

CPC分类号： G01N33/54326 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0427 ,  B01L2400/043 ,  C12M25/01 ,  C12M25/16 ,  G01N27/44717 ,  G01N27/44786 ,  G01N33/54386 ,  G01N35/0098 ,  G01N2035/1046

摘要： A droplet actuator device (600) comprises: an array of electrodes (622) on a substrate (614) configured for conducting one or more droplet operations; a magnet (638) that exerts a magnetic field on a droplet (634) positioned on a first set of one or more of the electrodes (622); and a magnetic shield (642) that shields a droplet (634) positioned on a second set of one or more of the electrodes (622) from the magnetic field. A method of conducting a droplet operation using the device comprises: positioning a first droplet (634) comprising one or more magnetically responsive beads on one or more electrodes (622) from the first set, so that the beads are attracted by the magnetic field; positioning a second droplet comprising one or more magnetically responsive beads on one or more electrodes from the second set, so that the beads are not attracted by the magnetic field; and conducting a droplet operation on the first droplet and/or the second droplet.

摘要翻译： 液滴致动器装置（600）包括：在衬底（614）上的电极阵列（622），其配置为用于进行一个或多个液滴操作; 磁体（638），其在位于第一组一个或多个电极（622）上的液滴（634）上施加磁场; 以及将位于第二组一个或多个电极（622）上的液滴（634）与磁场屏蔽的磁屏蔽（642）。 使用该装置进行液滴操作的方法包括：将包括一个或多个磁性响应珠粒的第一液滴（634）定位在来自第一组的一个或多个电极（622）上，使得珠粒被磁场吸引; 将包含一个或多个磁响应珠的第二液滴定位在来自第二组的一个或多个电极上，使得珠不被磁场吸引; 并在第一液滴和/或第二液滴上进行液滴操作。