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公开(公告)号：EP3607821A1
公开(公告)日：2020-02-12
申请号：EP19174479.6
申请日：2014-03-14
IPC分类号： A01N43/78 , A61K31/425 , C07C309/00
摘要： Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
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公开(公告)号：EP2766044A1
公开(公告)日：2014-08-20
申请号：EP12840725.1
申请日：2012-10-15
发明人： PETERS, Kevin , SHALWITZ, Robert
IPC分类号： A61K39/395
摘要： Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.
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公开(公告)号：EP3505182A1
公开(公告)日：2019-07-03
申请号：EP18201774.9
申请日：2012-10-15
发明人： PETERS, Kevin , SHALWITZ, Robert
IPC分类号： A61K39/395
摘要： Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, sepsis, cancer or the presence of pathogens.
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公开(公告)号：EP2766044B1
公开(公告)日：2019-12-11
申请号：EP12840725.1
申请日：2012-10-15
发明人： PETERS, Kevin , SHALWITZ, Robert
IPC分类号： A61K39/395
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公开(公告)号：EP3116503A1
公开(公告)日：2017-01-18
申请号：EP15760687.2
申请日：2015-03-13
发明人： JANUSZ, John , COPP, James , PETERS, Kevin
IPC分类号： A61K31/427
CPC分类号： C07D417/04
摘要： Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed.
摘要翻译： 本文公开了有效活化Tie-2和抑制HPTP-β的化合物。 该化合物可以为与血管发生相关的病症提供有效的治疗，例如眼睛状况。 公开了增加溶解度的配方。
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公开(公告)号：EP3487518A1
公开(公告)日：2019-05-29
申请号：EP17831790.5
申请日：2017-07-19
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7.发明公开
公开(公告)号：EP2967066A1
公开(公告)日：2016-01-20
申请号：EP14762974.5
申请日：2014-03-14
IPC分类号： A01N43/78 , A61K31/425 , C07C309/00
CPC分类号： C07D417/12 , A61K9/0019 , A61K9/0051 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/538 , A61K38/179 , A61K39/3955 , A61K47/26 , A61K47/40 , A61K47/6951 , A61K2039/505 , A61K2039/54 , A61P27/00 , A61P27/02 , C07D277/28 , C07D277/30 , C07D277/56 , C07D277/60 , C07D277/64 , C07D417/04 , C07K16/22 , A61K2300/00
摘要： Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.
摘要翻译： 本文公开了对于激活Tie-2和抑制HPTP-β有效的化合物。 该化合物可以为与血管生成相关的病症例如眼部病症提供有效的治疗。 公开了用于增加溶解度的配方。 还公开了与抗体和PK / PD数据的组合疗法。
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公开(公告)号：EP3501536A1
公开(公告)日：2019-06-26
申请号：EP18202143.6
申请日：2012-10-15
发明人： PETERS, Kevin , SHALWITZ, Robert
IPC分类号： A61K39/395
摘要： Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.
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公开(公告)号：EP2766043A1
公开(公告)日：2014-08-20
申请号：EP12840220.3
申请日：2012-10-15
发明人： PETERS, Kevin , SHALWITZ, Robert
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/40
摘要： Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, sepsis, cancer or the presence of pathogens.
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