公开(公告)号：EP2211887B1

公开(公告)日：2018-03-21

申请号：EP08843011.1

申请日：2008-10-17

申请人： Affinergy, Inc. ,  Synthes GmbH

发明人： DARBY, Martyn, K. ,  SANFORD, Isaac, G. ,  BENSON, R., Edward ,  GRON, Hanne ,  HAMILTON, Paul, T. ,  NAIR, Shrikumar, A. ,  BUECHTER, Doug ,  GRUSKIN, Elliott

IPC分类号： A61K38/00 ,  A61L27/22 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/08 ,  C07K7/08 ,  C07K7/06

CPC分类号： C07K7/06 ,  A61L27/227 ,  A61L27/28 ,  A61L27/54 ,  A61L29/048 ,  A61L29/08 ,  A61L29/16 ,  A61L31/047 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/406 ,  C07K7/08 ,  C07K14/001 ,  C07K2319/00

摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

公开(公告)号：EP2211887A1

公开(公告)日：2010-08-04

申请号：EP08843011.1

申请日：2008-10-17

申请人： Affinergy, Inc. ,  Synthes GmbH

发明人： DARBY, Martyn, K. ,  SANFORD, Isaac, G. ,  BENSON, R., Edward ,  GRON, Hanne ,  HAMILTON, Paul, T. ,  NAIR, Shrikumar, A. ,  BUECHTER, Doug ,  GRUSKIN, Elliott

IPC分类号： A61K38/00

CPC分类号： C07K7/06 ,  A61L27/227 ,  A61L27/28 ,  A61L27/54 ,  A61L29/048 ,  A61L29/08 ,  A61L29/16 ,  A61L31/047 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/406 ,  C07K7/08 ,  C07K14/001 ,  C07K2319/00

摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

公开(公告)号：EP1793875B9

公开(公告)日：2010-09-08

申请号：EP05857694.3

申请日：2005-06-15

申请人： Affinergy, Inc.

发明人： HAMILTON, Paul, T. ,  GRINSTAFF, Mark, W. ,  KENAN, Daniel, J. ,  CHRISTENSEN, Dale, J. ,  BEYER, Wayne, Fl., Jr. ,  HYDE-DeRUYSCHER, Robin ,  BENSON, Ray, Edward

IPC分类号： A61L27/22 ,  A61L27/34 ,  G01N33/543

CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/606 ,  C07K7/08 ,  C07K14/001 ,  C08L89/00

摘要： The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.

公开(公告)号：EP1793875A2

公开(公告)日：2007-06-13

申请号：EP05857694.3

申请日：2005-06-15

申请人： Affinergy Inc.

发明人： HAMILTON, Paul, T. ,  GRINSTAFF, Mark, W. ,  KENAN, Daniel, J. ,  CHRISTENSEN, Dale, J. ,  BEYER, Wayne, Fl., Jr. ,  HYDE-DeRUYSCHER, Robin ,  BENSON, Ray, Edward

IPC分类号： A61L27/22 ,  A61L27/34 ,  G01N33/543

CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/606 ,  C07K7/08 ,  C07K14/001 ,  C08L89/00

摘要： The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.

公开(公告)号：EP1793875B1

公开(公告)日：2010-03-31

申请号：EP05857694.3

申请日：2005-06-15

申请人： Affinergy, Inc.

发明人： HAMILTON, Paul, T. ,  GRINSTAFF, Mark, W. ,  KENAN, Daniel, J. ,  CHRISTENSEN, Dale, J. ,  BEYER, Wayne, Fl., Jr. ,  HYDE-DeRUYSCHER, Robin ,  BENSON, Ray, Edward

IPC分类号： A61L27/22 ,  A61L27/34 ,  G01N33/543

CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/606 ,  C07K7/08 ,  C07K14/001 ,  C08L89/00

公开(公告)号：EP1771214A2

公开(公告)日：2007-04-11

申请号：EP05786727.7

申请日：2005-06-15

申请人： Affinergy Inc.

发明人： HAMILTON, Paul, T. ,  GRINSTAFF, Mark, W. ,  KENAN, Daniel, J. ,  CHRISTENSEN, Dale, J. ,  BEYER, Wayne, F., Jr. ,  HYDE-DERUYSCHER, Robin ,  BENSON, Ray, Edward

IPC分类号： A61L27/22 ,  A61L27/34 ,  G01N33/543

CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/606 ,  C07K7/08 ,  C07K14/001 ,  C08L89/00

摘要： The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial (“IFBM”) which comprises at least one binding module that binds to the surface of a device (“surface-binding module”) and at least one binding module that performs another function (“affector module”) and which acts to inhibit biofilm formation.