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1.发明公开
公开(公告)号：EP3418294A1
公开(公告)日：2018-12-26
申请号：EP18173555.6
申请日：2013-09-09
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： The invention relates to an isolated peptide tetramer comprising the formula [(RGRKWRR) 2 K] 2 KK and its derivatives thereof. The derivatives may comprise at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.
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2.发明公开TETRABRANCHED PEPTIDES AND ANALOGUES AS A NEW CLASS OF ANTIMICROBIALS AND THEIR PREPARATION THEREOF 有权TETRA支化肽和类似物抗菌剂及其生产一类新
公开(公告)号：EP2892914A1
公开(公告)日：2015-07-15
申请号：EP13834677.0
申请日：2013-09-09
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： The invention relates to an isolated peptide tetramer comprising the formula [(RGRKWRR)2K]2KK and its derivatives thereof. The derivatives may comprise at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.
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公开(公告)号：EP2892913A1
公开(公告)日：2015-07-15
申请号：EP13834422.1
申请日：2013-09-09
发明人： CHANDRA SHEKHAR, Verma , LI, Jianguo , RAJAMANI, Lakshminarayanan , BEUERMAN, Roger Wilmer , LIU, Shouping , KOH, Jun Jie
IPC分类号： C07K14/00 , C07K7/00 , A61K38/04 , A61K38/10 , A61K38/16 , A61P31/04 , A61P31/10 , A61L12/14
CPC分类号： C07K14/00 , A61K38/00 , C07K7/08 , Y02A50/475 , Y02A50/492
摘要： Disclosed are antimicrobial peptides. Also disclosed are methods of treating bacterial infection and fungal infection and a method of removing biofilm. Also disclosed is the use of these peptides.
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公开(公告)号：EP3969448A1
公开(公告)日：2022-03-23
申请号：EP20809100.9
申请日：2020-05-18
申请人： Singapore Health Services Pte. Ltd. , Agency for Science, Technology and Research , Tan Tock Seng Hospital Pte Ltd
发明人： AUNG, Thet Tun , LI, Jianguo , KOH, Jun Jie , RAJAMANI, Lakshminarayanan , BEUERMAN, Roger , TAN, Tiang Hwee Donald , PERIAYAH, Mercy Halleluyah , VERMA, Chandra Shekhar , CHEN, Swaine , BARKHAM, Timothy
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4433 , A61K31/444 , A61P31/04
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5.发明授权
公开(公告)号：EP2892914B1
公开(公告)日：2018-05-23
申请号：EP13834677.0
申请日：2013-09-09
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： An isolated peptide tetramer includes the formula [(RGRKVVRR)2K]2KK and its derivatives thereof. The derivatives may include at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.
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公开(公告)号：EP3519426A1
公开(公告)日：2019-08-07
申请号：EP17868131.8
申请日：2017-10-31
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公开(公告)号：EP4007573A1
公开(公告)日：2022-06-08
申请号：EP20849062.3
申请日：2020-08-03
IPC分类号： A61K31/205 , A61K31/702 , A61K31/195 , A61K31/185 , A61P27/02
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公开(公告)号：EP3319779A1
公开(公告)日：2018-05-16
申请号：EP16821928.5
申请日：2016-07-06
发明人： RAJAMANI, Lakshminarayanan , DHAND, Chetna , RAMAKRISHNA, Seeram , LIU, Shouping , BEUERMAN, Roger Wilmer
IPC分类号： B29C47/00
CPC分类号： A61F13/53 , C08G63/08 , C08K3/10 , C08K5/175 , C08L5/08 , C08L71/02 , C08L77/04 , C08L2203/12 , D01D5/003 , D01F1/10 , D01F1/103 , D01F11/00 , D01F11/02 , D01F11/06 , D01F11/08
摘要： The present invention provides a polymer product and a method for preparing the polymer product comprising electrospinning from a dope solution comprising at least one polymer and at least one cross-linking agent to prepare and/or fabricate the polymer product. In certain embodiments, the cross-linking agent comprises at least one catecholamine or at least one polyphenol, wherein the method comprises (i) electrospinning the biocompatible polymer product using a dope solution comprising a polymer and at least one catecholamine or at least one polyphenol and (ii) exposing the polymer product to at least one gaseous alkaline reagent. The dope solutions and polymer products of the invention can further include antimicrobial agents, metal ions, and other substances.
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