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1.发明公开Micro device having integrated electrospray emitter and method of producing same 审中-公开具有集成电喷射发射器的微型器件及其制造方法
公开(公告)号：EP1544160A2
公开(公告)日：2005-06-22
申请号：EP04257232.1
申请日：2004-11-22
发明人： Brennen, Reid A.
CPC分类号： B81B1/00 , G01N30/6095 , G01N30/7266 , H01J49/167 , Y10T137/2191 , Y10T137/2224
摘要： A micro device (10) is constructed from a substrate (12) having a microchannel (18) formed therein and a cover plate (32) arranged over the substrate (12). The cover plate (32) in combination with the microchannel (18) at least partially defines a conduit (31) within the micro device (10). The conduit (32) has a surface that extends from an upstream region toward a downstream region and terminates at an opening. The micro device (10) also includes an annular lining (24A) that conforms to the conduit surface at the downstream region and extends from the opening (40) toward the upstream region in the conduit (31). An emitter (42) may be produced in situ by depositing an emitter material (42A) on the annular lining (24A). In addition, material may be removed from the cover plate (32) and/or substrate (12) about the opening (40). As a result, an exterior micro device surface is formed and a downstream portion of the emitter (42) is exposed that protrudes from the exterior surface.
摘要翻译： 微型器件（10）由其中形成有微通道（18）的衬底（12）和布置在衬底（12）上的盖板（32）构成。 与微通道（18）结合的盖板（32）至少部分地限定微器件（10）内的导管（31）。 导管（32）具有从上游区域向下游区域延伸并终止于开口的表面。 微型装置（10）还包括环形衬里（24A），其与下游区域处的导管表面相符并从开口（40）朝向导管（31）中的上游区域延伸。 发射器（42）可以通过在环形衬里（24A）上沉积发射器材料（42A）而原位制造。 另外，材料可以从盖板（32）和/或基板（12）围绕开口（40）移除。 结果，形成外部微器件表面，并且暴露发射器（42）的下游部分，其从外表面突出。
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2.发明公开Micro device having integrated electrospray emitter and method of producing same 审中-公开微组件具有集成电喷雾源和处理它的制备
公开(公告)号：EP1544160A3
公开(公告)日：2005-10-19
申请号：EP04257232.1
申请日：2004-11-22
发明人： Brennen, Reid A.
CPC分类号： B81B1/00 , G01N30/6095 , G01N30/7266 , H01J49/167 , Y10T137/2191 , Y10T137/2224
摘要： A micro device (10) is constructed from a substrate (12) having a microchannel (18) formed therein and a cover plate (32) arranged over the substrate (12). The cover plate (32) in combination with the microchannel (18) at least partially defines a conduit (31) within the micro device (10). The conduit (32) has a surface that extends from an upstream region toward a downstream region and terminates at an opening. The micro device (10) also includes an annular lining (24A) that conforms to the conduit surface at the downstream region and extends from the opening (40) toward the upstream region in the conduit (31). An emitter (42) may be produced in situ by depositing an emitter material (42A) on the annular lining (24A). In addition, material may be removed from the cover plate (32) and/or substrate (12) about the opening (40). As a result, an exterior micro device surface is formed and a downstream portion of the emitter (42) is exposed that protrudes from the exterior surface.
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公开(公告)号：EP1584922B1
公开(公告)日：2014-08-06
申请号：EP05252222.4
申请日：2005-04-08
IPC分类号： G01N30/56
CPC分类号： G01N30/56 , B01J2219/00466 , G01N2030/565 , G01N2035/00574
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4.发明公开
公开(公告)号：EP1760765A2
公开(公告)日：2007-03-07
申请号：EP06000653.3
申请日：2006-01-12
IPC分类号： H01J49/10
CPC分类号： H01J49/10
摘要： The invention described herein provides a mass spectrometry system, having an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, a second gas source for supplying gas at a defined flow to the ionization region, and a detector downstream from the ion source for detecting ions produced by the ion source. The invention also provides an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, and a second gas source for supplying gas at a defined flow to the ionization region.
A method for producing analyte ions is also disclosed. The method includes producing analyte ions from an ionization device, directing a first heated gas toward the analyte ions to desolvate the analyte ions, and directing a second gas toward the analyte ions at a defined and continual flow rate.摘要翻译： 本发明提供了一种质谱系统，其具有离子源，该离子源包括用于产生离子的离子化装置，与电离装置相邻的收集管，用于收集由离子化装置产生的离子;第一气体源， 通过电离装置将用于以规定的流量供给到电离区域的气体的第二气体源和离子源下游的检测器，用于检测由离子源产生的离子。 本发明还提供了一种离子源，其包括用于产生离子的离子化装置，与离子化装置相邻的用于收集由离子化装置产生的离子的收集管，用于向由离子化装置产生的脱溶质离子供给气体的第一气体源， 用于以限定的流将气体供应到电离区域的第二气体源。 还公开了一种生产分析离子的方法。 该方法包括从电离装置产生分析物离子，将第一加热气体引向分析物离子以使分析物离子脱溶质，并以限定和持续的流速将第二气体引向分析物离子。
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公开(公告)号：EP1584922A3
公开(公告)日：2006-04-12
申请号：EP05252222.4
申请日：2005-04-08
IPC分类号： G01N30/56
CPC分类号： G01N30/56 , B01J2219/00466 , G01N2030/565 , G01N2035/00574
摘要： Provided are apparatuses and methods for introducing particles into a microdevice conduit (31). Also provided are microdevices (10) containing a plurality of particles that occupy at least about 25 volume percent of microconduit. In some instances, particles may controllably form a particle bridge in a bridging zone within a microdevice.
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公开(公告)号：EP1584922A2
公开(公告)日：2005-10-12
申请号：EP05252222.4
申请日：2005-04-08
IPC分类号： G01N30/56
CPC分类号： G01N30/56 , B01J2219/00466 , G01N2030/565 , G01N2035/00574
摘要： Provided are apparatuses and methods for introducing particles into a microdevice conduit (31). Also provided are microdevices (10) containing a plurality of particles that occupy at least about 25 volume percent of microconduit. In some instances, particles may controllably form a particle bridge in a bridging zone within a microdevice.
摘要翻译： 提供了将颗粒引入微型设备导管（31）中的装置和方法。 还提供了包含占据至少约25体积％微管的多个颗粒的微器件（10）。 在一些情况下，颗粒可以可控地形成微型装置内的桥接区域中的颗粒桥。
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