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公开(公告)号：EP2565648B1
公开(公告)日：2017-07-19
申请号：EP12180829.9
申请日：2002-12-27
发明人： Seul, Michael , Chau, Chiu Wo , Huang, Hui , Banerjee, Sukanta , Hong, Ye , Yang, Jiacheng
IPC分类号： G01N33/543 , G01N33/533 , C07H1/00 , C07H21/00 , C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： The present invention provides methods for quality control of biochip manufacture, preferably where the substrate is a semiconductor and the biochip carries bio-functionalized microbeads.
摘要翻译： 本发明提供了用于生物芯片制造的质量控制的方法，优选地，其中衬底是半导体并且生物芯片承载生物功能化的微珠。
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2.发明公开BEAD SEALING METHOD, METHOD FOR DETECTING TARGET MOLECULE, ARRAY, KIT, AND TARGET MOLECULE DETECTION DEVICE 审中-公开珠状密封方法，检测目标分子，阵列，试剂盒和目标分子检测装置的方法
公开(公告)号：EP2685266A1
公开(公告)日：2014-01-15
申请号：EP12754743.8
申请日：2012-03-07
发明人： NOJI, Hiroyuki , IINO, Ryota , ARAKI, Suguru
CPC分类号： G01N33/54386 , B01J2219/00317 , B01J2219/00466 , B01J2219/00619 , B01J2219/00621 , B01L3/502715 , B01L3/502761 , B01L3/50853 , B01L2200/0642 , B01L2200/0668 , B01L2200/12 , B01L2300/0627 , B01L2300/0819 , B01L2300/0829 , B01L2300/0858 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , G01N21/6452 , G01N33/54306 , G01N33/54313
摘要： This invention provides a technique enabling to detect target molecules of low concentration with high sensitivity. This invention includes (i) a step of introducing a hydrophilic solvent (42) containing beads (40),(41') into a space (30) between (a) a lower layer section (10) including a plurality of receptacles (13) each of which is capable of storing only one of the beads (41),(41') and which are separated from each other by a side wall (12) having a hydrophobic upper surface and (b) an upper layer section (20) facing a surface of the lower layer section (10) on which surface the plurality of receptacles (13) are provided; and (ii) a step of introducing a hydrophobic solvent (43) into the space (30), the step (ii) being carried out after the step (i).
摘要翻译： 本发明提供了一种能够以高灵敏度检测低浓度目标分子的技术。 本发明包括：（i）将包含珠粒（40），（41'）的亲水性溶剂（42）引入（a）包括多个容器（13）的下层部分（10） ），它们中的每一个能够仅储存一个珠状物（41），（41'）并且通过具有疏水上表面的侧壁（12）和（b）上层部分（20）彼此分开 ）面对所述多个容器（13）设置在其上的所述下层部分（10）的表面; 和（ii）将疏水性溶剂（43）引入空间（30）的步骤，步骤（ii）在步骤（i）之后进行。
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3.发明公开A MICROARRAY SYSTEM AND A PROCESS FOR PRODUCING MICROARRAYS 审中-公开MIKROARRAY-SYSTEM UND VERFAHREN ZUR MIKROARRAY-HERSTELLUNG
公开(公告)号：EP2054711A4
公开(公告)日：2013-05-01
申请号：EP07794246
申请日：2007-08-03
申请人： UNIV SINGAPORE
发明人： TRAU DIETER , LIU WEN-TSO , NG KIAN KOK JOHNSON
CPC分类号： G01N33/54373 , B01J19/0046 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/0054 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/0074 , C12Q1/6834 , C12Q1/6837 , C12Q1/6883 , C40B20/02 , C40B30/04 , C40B40/04 , C40B50/16 , C40B50/18 , C40B60/14 , G01N21/6452 , G01N33/54313 , G01N33/545 , G06T5/50 , G06T7/0008 , G06T7/33 , C12Q2537/149 , C12Q2563/149 , C12Q2565/513 , C12Q2565/619
摘要： A process for making a micro-array. The process comprises the step of depositing a population of microbeads on a substrate having at least one fiducial. The population being comprised of at least two sub-populations, preferably multiple sub-populations, each comprising a known active agent capable of specific binding with at least one target analyte. The said subpopulations are deposited sequentially and at discrete periods of each other. The process also comprises the step of making images of the substrate after deposition of each subpopulation. The images are then compared using the fiducial as a reference to thereby determine the location of each microbead and to identify the subpopulation, and its known active agent, based on differences between each image. Also disclosed in a system for using the microarray.
摘要翻译： 制作微阵列的过程。 该方法包括在具有至少一个基准的基底上沉积一群微珠的步骤。 群体由至少两个亚群组成，优选多个亚群体，每个亚群包含能够与至少一种目标分析物特异性结合的已知活性剂。 所述亚群是相互沉积的，彼此间隔离散。 该方法还包括在每个亚群沉积后制作基底的图像的步骤。 然后使用基准作为参考来比较图像，从而基于每个图像之间的差异来确定每个微珠的位置并识别亚群及其已知的活性剂。 还在用于使用微阵列的系统中公开。
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4.发明公开Arrays of microparticles and methods of preparation thereof 有权Mikropartikelanordnungen und Herstellungsverfahrendafür
公开(公告)号：EP2565648A1
公开(公告)日：2013-03-06
申请号：EP12180829.9
申请日：2002-12-27
发明人： Seul, Michael , Chau, Chiu Wo , Huang, Hui , Banerjee, Sukanta , Hong, Ye , Yang, Jiacheng
IPC分类号： G01N33/543 , G01N33/533 , C07H1/00 , C07H21/00 , C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chip and/or multichip arrays of this invention are useful for chemical and biological arrays.
摘要翻译： 本发明提供了高单位密度的微粒阵列和组装这种阵列的方法。 阵列中的微粒可以用给定目标分析物特异性的化学或生物实体来官能化。 根据本文所述的方法，本发明的高单位密度阵列形成在可以组合以形成多芯片阵列的芯片上。 本发明的芯片和/或多芯片阵列可用于化学和生物阵列。
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公开(公告)号：EP1461619B1
公开(公告)日：2011-04-27
申请号：EP02793118.7
申请日：2002-12-27
发明人： WEBER, Achim , SCHIESTEL, Thomas , TOVAR, Günter , BRUNNER, Herwig , RUPP, Steffen , HAUSER, Nicole
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/552 , G01N33/553 , B01J19/00
CPC分类号： G01N33/54346 , B01J19/0046 , B01J2219/00382 , B01J2219/00427 , B01J2219/00466 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B82Y30/00 , C40B60/14 , G01N33/54393
摘要： The invention relates to functional elements comprising microstructures which are arranged on a carrier and contain bio-functionalized nanoparticles, methods for producing said functional elements, and the use thereof.
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公开(公告)号：EP2205968A1
公开(公告)日：2010-07-14
申请号：EP08836072.2
申请日：2008-10-02
申请人： Theranos, Inc.
IPC分类号： G01N33/48
CPC分类号： G01N33/5304 , A61B5/15 , A61B5/150755 , A61B5/151 , A61B10/0038 , A61B10/0045 , A61B10/0051 , A61B10/0058 , A61B10/007 , A61B10/02 , A61B2010/0074 , A61B2010/0077 , B01J19/0046 , B01J2219/00283 , B01J2219/00292 , B01J2219/00315 , B01J2219/00369 , B01J2219/00371 , B01J2219/00385 , B01J2219/00466 , B01J2219/00495 , B01J2219/005 , B01J2219/00693 , B01J2219/00702 , B01L3/021 , B01L3/0262 , B01L3/5025 , B01L3/527 , B01L7/52 , B01L7/5255 , B01L9/543 , B01L2200/04 , B01L2200/0689 , B01L2200/141 , B01L2200/148 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , B01L2400/043 , G01N1/38 , G01N33/5302 , G01N33/54326 , G01N33/54366 , G01N33/54386 , G01N33/56966 , G01N33/57484 , G01N33/6803 , G01N33/94 , G01N35/00732 , G01N35/00871 , G01N35/028 , G01N35/10 , G01N35/1065 , G01N35/1074 , G01N2035/00237 , G01N2035/00851 , G01N2035/00881 , G01N2035/0097 , G01N2035/1032 , G01N2035/1034 , G01N2035/1048 , G01N2333/4737 , G01N2333/475 , G01N2333/71 , G01N2333/912 , G01N2333/91205 , G01N2333/9129 , G01N2800/26 , G01N2800/60 , Y10T29/49826 , Y10T436/25375
摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
摘要翻译： 本发明提供了在护理点使用的装置和系统。 本发明的方法装置旨在自动检测体液中的分析物。 器件的组件是模块化的，以允许使用所公开的各种医疗应用的方法的灵活性和鲁棒性。
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公开(公告)号：EP1432989B1
公开(公告)日：2009-12-02
申请号：EP02800906.6
申请日：2002-10-04
申请人： SurModics, Inc.
IPC分类号： G01N33/543 , C12Q1/68 , B01J19/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00725 , B82Y5/00 , B82Y10/00 , C12Q1/6837 , G01N33/54366 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816 , C12Q2563/149
摘要： Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.
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公开(公告)号：EP1307743B1
公开(公告)日：2008-12-24
申请号：EP01932980.4
申请日：2001-05-04
IPC分类号： G01N33/543
CPC分类号： G01N33/54346 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00641 , B01J2219/00648 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01L3/5023 , B82Y30/00 , C40B40/06 , C40B40/10 , G01N33/54366
摘要： A liquid composition comprising a colloidal suspension of a biomolecule-binding matrix material (preferably nitrocellulose) dispersed in a liquid, with particles of the matrix material being of a defined particle size, and replicate copies of a biomolecule, e.g., protein or nucleic acid probes, which are distributed, preferably uniformly, throughout the colloidal suspension and are bound to the matrix material particles, is disclosed. The liquid composition of the invention can be used directly for sample analysis or preparation of biomolecules, or aliquots of the composition can be spotted onto a support to form a microporous matrix system or microarray for analysis or preparation of biomolecules. Compositions and microarrays according to the invention are useful in any type of analytical or preparative procedure relating to biomolecules. They are particularly useful, e.g., in methods for detecting a biomolecule analyte in a liquid sample, methods for determining the presence of a particular nucleic acid sequence within a liquid sample and methods for determining the presence of a drug candidate molecule in a liquid sample. The invention further comprises kits for practicing the various methods of the invention.
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公开(公告)号：EP1895289A3
公开(公告)日：2008-09-10
申请号：EP07023438.0
申请日：2000-04-06
发明人： Walt, David R. , Dickinson, Todd A.
IPC分类号： C12Q1/68 , G01N33/543 , G01N21/77 , G06F19/00
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
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10.发明公开BIOMOLECULAR SUBSTRATE, METHOD OF TESTING OR DIAGNOSIS WITH USE THEREOF AND APPARATUS THEREFOR 有权生物分子基质测试，或诊断过程THEREOF及其装置使用
公开(公告)号：EP1507145A4
公开(公告)日：2007-11-21
申请号：EP03721047
申请日：2003-05-07
发明人： OSHIMA MITSUAKI
CPC分类号： G01N33/54313 , B01J19/0046 , B01J2219/00286 , B01J2219/00378 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/0052 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01L3/545 , G01N35/00069 , G01N2035/00158
摘要： An apparatus for testing a DNA substrate having multiple DNA fragments for testing arranged thereon, which avoids a construction needing absolute precision. In particular, a substrate on which multiple biomolecular spots composed of a mass of biomolecules of specified species (for example, DNAs, etc.) are formed, wherein the pattern or arrangement of the biomolecular spots (DNA, etc.) is varied in conformity with specified data so that information regarding the specified data is recorded.
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