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公开(公告)号：EP2406389B1
公开(公告)日：2019-05-08
申请号：EP10751525.6
申请日：2010-03-12
发明人： DANG, Lenny , FANTIN, Valeria , GROSS, Stefan , JANG, Hyun Gyung , JIN, Shengfang , SALITURO, Francesco G. , SAUNDERS, Jeffrey, O. , SU, Shin-San Michael , YEN, Katharine
IPC分类号： G01N33/574 , C12Q1/32 , A61P35/00
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公开(公告)号：EP3406608A1
公开(公告)日：2018-11-28
申请号：EP18164959.1
申请日：2013-01-05
发明人： CIANCHETTA, Giovanni , DELABARRE, Byron , POPOVICI-MULLER, Janeta , SALITURO, Francesco G. , SAUNDERS, Jeffrey O. , TRAVINS, Jeremy M. , YAN, Shunqi , GUO, Tao , ZHANG, Li
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds being inhibitors of mutant IDH2 useful for treating cancer, methods for preparing such compounds and methods of treating cancer by administering to a subject in need thereof a compound described herein.
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公开(公告)号：EP2721019B1
公开(公告)日：2018-08-08
申请号：EP12800001.5
申请日：2012-06-18
发明人： CAO, Sheldon , POPOVICI-MULLER, Janeta , SALITURO, Francesco G. , SAUNDERS, Jeffrey, O. , TRAVINS, Jeremy , TAN, Xuefei , YAN, Shunqi , YE, Zhixiong
IPC分类号： C07D213/85 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D417/14 , C07D487/04 , C07D498/04 , A61K31/44 , A61K31/496 , A61P35/00
CPC分类号： C07F9/650952 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/675 , C07D213/85 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07F9/65583
摘要： Provided are compounds with the following structure, formula (I) pharmaceutically acceptable salts thereof, use of those compounds for treating cancer and pharmaceutical compositions comprising those compounds.
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公开(公告)号：EP2800743B1
公开(公告)日：2018-04-04
申请号：EP13733752.3
申请日：2013-01-05
发明人： CIANCHETTA, Giovanni , DELABARRE, Byron , POPOVICI-MULLER, Janeta , SALITURO, Francesco G. , SAUNDERS, Jeffrey O. , TRAVINS, Jeremy M. , YAN, Shunqi , GUO, Tao , ZHANG, Li
IPC分类号： C07D251/18 , C07D251/26 , A61K31/53 , A61P35/00 , C07D401/14 , C07D405/14 , C07D403/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D493/08 , C07D417/04
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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5.发明授权THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION 有权用于治疗癌症特征为具有IDH突变的治疗活性化合物
公开(公告)号：EP2509600B1
公开(公告)日：2017-08-02
申请号：EP10796233.4
申请日：2010-12-09
IPC分类号： A61K31/495 , A61K31/496 , A61K31/506 , A61K31/551 , C07D243/08 , C07D405/12 , C07D213/72 , C07D239/42 , C07D471/04 , C07D295/192 , A61P35/00
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/551 , C07D209/04 , C07D213/71 , C07D213/72 , C07D215/38 , C07D239/42 , C07D243/08 , C07D249/04 , C07D271/10 , C07D471/04
摘要： Compounds and compositions comprising compounds useful in the treatment of cancer are described herein.
摘要翻译： 本文描述了包含可用于治疗癌症的化合物的化合物和组合物。
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6.发明授权NOVEL N-(4-(AZETIDINE-1-CARBONYL)PHENYL)-(HETERO-)ARYLSULFONAMIDE DERIVATIVES AS PYRUVATE KINASE M2 (PMK2) MODULATORS 有权NEW N-（4-（氮杂环丁烷 - 1 - 羰基）苯基） - （杂烷基）-ARYLSULFONAMIDDERIVATE ALS-M2丙酮酸激酶（PMK2）调节剂
公开(公告)号：EP2651898B1
公开(公告)日：2015-12-09
申请号：EP11808773.3
申请日：2011-12-16
IPC分类号： C07D215/36 , C07D401/12 , A61K31/397 , A61P35/00
CPC分类号： C07D401/12 , A61K31/4709 , C07D215/36 , C07D401/14
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公开(公告)号：EP2922850A1
公开(公告)日：2015-09-30
申请号：EP13857585.7
申请日：2013-11-21
发明人： LEMIEUX, Rene M. , POPOVICI-MULLER, Janeta , SALITURO, Francesco G. , SAUNDERS, Jeffrey O. , TRAVINS, Jeremy M. , CHEN, Yongsheng
IPC分类号： C07D417/08 , C07D417/14 , C07D413/08 , C07D413/14 , A61K31/433 , A61K31/4245 , A61P35/00
CPC分类号： C07D417/14 , C07D285/135
摘要： Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.
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公开(公告)号：EP2406389A1
公开(公告)日：2012-01-18
申请号：EP10751525.6
申请日：2010-03-12
发明人： DANG, Lenny , FANTIN, Valeria , GROSS, Stefan , JANG, Hyun Gyung , JIN, Shengfang , SALITURO, Francesco G. , SAUNDERS, Jeffrey, O. , SU, Shinsan , YEN, Katharine
CPC分类号： A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/32 , C12Q1/6886 , C12Y101/01042 , G01N33/574 , G06F19/00 , G06F19/328 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要： Methods of treating and evaluating subjects having neoactive mutants are described herein.
摘要翻译： 本文描述了治疗和评估具有新活性突变体的受试者的方法。
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公开(公告)号：EP3456719A1
公开(公告)日：2019-03-20
申请号：EP18183580.2
申请日：2013-11-21
发明人： LEMIEUX, Rene M. , POPOVICI-MULLER, Janeta , SALITURO, Francesco G. , SAUNDERS, Jeffrey O. , TRAVINS, Jeremy , CHEN, Yongsheng
IPC分类号： C07D417/14 , A61K31/433 , A61K31/4245 , A61P35/00 , C07D285/135
摘要： Provided are compounds of formular (I), which can inhibit glutaminase. Pharmaceutial compositions comprising these compounds and uses as glutaminase inhibitors for treaing cancers thereof are also provided.
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公开(公告)号：EP2922850B1
公开(公告)日：2018-07-18
申请号：EP13857585.7
申请日：2013-11-21
发明人： LEMIEUX, Rene M. , POPOVICI-MULLER, Janeta , SALITURO, Francesco G. , SAUNDERS, Jeffrey O. , TRAVINS, Jeremy M. , CHEN, Yongsheng
IPC分类号： C07D417/14 , A61K31/433 , A61K31/4245 , A61P35/00 , C07D285/135
CPC分类号： C07D417/14 , C07D285/135
摘要： Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.
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