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公开(公告)号：EP3338785A1
公开(公告)日：2018-06-27
申请号：EP16205996.8
申请日：2016-12-21
申请人： Agriculture and Food Development Authority (TEAGASC) , University College Cork - National University of Ireland, Cork
IPC分类号： A61K35/747 , G01N33/48 , C12N1/20 , A61P31/04
CPC分类号： A61K35/747 , C12N1/20 , C12Q1/045 , G01N2333/33 , G01N2333/335
摘要： Clostridium difficile is one of the most common causes of health-care acquired diarrhoea, resulting in a spectrum of disease from mild diarrhoea to life-threatening illness. Particular human Lactobacillus strains, including Lactobacillus gasseri APC678, are described as useful therapeutic agents to target C. difficile colonisation or infection.
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公开(公告)号：EP3705131A1
公开(公告)日：2020-09-09
申请号：EP19160469.3
申请日：2019-03-04
申请人： University College Cork-National University of Ireland, Cork , Agriculture and Food Development Authority (TEAGASC)
发明人： ROSS, Reynolds Paul , STANTON, Catherine , HILL, Colin , RYAN, Anothony , O'SULLIVAN, Julie , WATKINS, Claire
摘要： An isolated lantibiotic is provided comprising amino acid sequence SEQ. ID No. 2 and at least one of amino acid sequences SEQ. ID No. 4 and SEQ. ID. No 6. Also provided is use of the lantibiotic in the treatment or prevention of infection by Group B Streptococcus or Corynebacterium xerosis. The invention further relates to isolated S. hominis strains and use of same in producing the lantibiotic. A vector is provided comprising nucleotides sequences for producing the lantibiotic.
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3.发明公开THURICIN CD, AN ANTIMICROBIAL FOR SPECIFICALLY TARGETING CLOSTRIDIUM DIFFICILE 审中-公开THURICIN CD，EIN SPEZIFISCH AUF CLOSTRIDIUM DIFFICILE ZIELENDES ANTIMIKROBIELLES MITTEL
公开(公告)号：EP2227484A1
公开(公告)日：2010-09-15
申请号：EP08855713.7
申请日：2008-11-28
申请人： TEAGASC, The Agriculture and Food Development Authority , University College Cork-National University of Ireland, Cork
发明人： HILL, Colin , REA, Mary , ROSS, Paul
CPC分类号： C07K14/32 , A61K38/00 , A61K2035/11 , C12N1/06 , C12R1/075 , Y10S435/832
摘要： The present invention relates to a new bacteriocin, to microbial strains which can produce it and to uses of the bacteriocin and the strains. The bacteriocin is effective against Clostridium difficile and Listeria monocytogenes amongst other organisms.
摘要翻译： 本发明涉及一种新的细菌素，可以产生它的微生物菌株以及细菌素和菌株的用途。 细菌素在其他生物体内对艰难梭菌和单核细胞增生利斯特氏菌有效。
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公开(公告)号：EP1089754A2
公开(公告)日：2001-04-11
申请号：EP99928186.8
申请日：1999-06-22
申请人： TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY , University College Cork-National University of Ireland, Cork
发明人： ROSS, Reynolds Paul , HILL, Colin
IPC分类号： A61K38/16
CPC分类号： A61K38/164 , A61K9/0041 , A61K2300/00
摘要： An antimicrobial which is effective against a range of Gram positive organisms is described. The antimicrobial is the bacteriocin lacticin 3147, which is shown to be effective both in vivo and in vitro against a range of Gram positive organisms.
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公开(公告)号：EP3934676A1
公开(公告)日：2022-01-12
申请号：EP20706770.3
申请日：2020-03-04
申请人： University College Cork-National University of Ireland Cork , TEAGASC, The Agriculture and Food Development Authority
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公开(公告)号：EP2280990A1
公开(公告)日：2011-02-09
申请号：EP09742163.0
申请日：2009-05-08
发明人： COTTER, Paul , HILL, Colin
IPC分类号： C07K14/195
CPC分类号： C07K14/315 , A23C19/11 , A23L3/34635 , A61K38/164
摘要： The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.
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公开(公告)号：EP3822285A1
公开(公告)日：2021-05-19
申请号：EP19208735.1
申请日：2019-11-12
申请人： University College Cork-National University of Ireland, Cork , TEAGASC, The Agriculture and Food Development Authority
发明人： COTTER, Paul , SHEEHAN, Diarmuid , BHAGYA JONNALA, Rekha , FIELD, Des , HILL, Colin , ROSS, Paul
IPC分类号： C07K14/315 , A23L3/3526 , A61K38/16
摘要： The invention relates to a variant nisin peptide, wherein the variant nisin peptide is a modified variant of wild-type nisin, wherein the modification comprises or consists of an amino acid residue modification selected from: i) M17Q or M17A; ii) T2L; and iii) one set of modified hinge residues selected from a) N20H and M21T, b) N20V, M21G, and K22A, c) N20V, M21G, and K22V or d) N20V, M21G, and K22T; or v) combinations of modifications i), ii), and iii), and related medical uses and products comprising such nisin peptides.
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公开(公告)号：EP2280990B1
公开(公告)日：2020-04-08
申请号：EP09742163.0
申请日：2009-05-08
发明人： COTTER, Paul , HILL, Colin
IPC分类号： C07K14/195
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公开(公告)号：EP1090035B1
公开(公告)日：2008-02-13
申请号：EP99928187.6
申请日：1999-06-22
申请人： TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY , University College Cork-National University of Ireland, Cork
发明人： ROSS, Reynolds, Paul , HILL, Colin
IPC分类号： C07K14/315 , A23L3/3463 , A23C9/123 , A23C9/158
CPC分类号： A23C9/13 , A23C9/1232 , A23C19/11 , A23L3/3463 , A23L3/34635 , A23Y2240/41 , C07K14/315
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公开(公告)号：EP1090035A1
公开(公告)日：2001-04-11
申请号：EP99928187.6
申请日：1999-06-22
申请人： TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY , University College Cork-National University of Ireland, Cork
发明人： ROSS, Reynolds, Paul , HILL, Colin
IPC分类号： C07K14/315 , A23L3/3463 , A23C9/123 , A23C9/158
CPC分类号： A23C9/13 , A23C9/1232 , A23C19/11 , A23L3/3463 , A23L3/34635 , A23Y2240/41 , C07K14/315
摘要： The production of a spray-dried bacteriocin lacticin 3147 powder is described. The powder is shown to have effective anti-microbial activity in a range of foodstuffs, namely infant milk formulations, powdered soup, yoghurt and cottage cheese. Increased anti-microbial activity was demonstrated when the lacticin 3147 powder was used in conjunction with increased hydrostatic pressure. The process comprises: inoculating a medium with a lacticin 3147-producing strain of bacteria, fermenting the inoculated medium, adjusting the pH of the fermentation to 6.3-6.7, inactivating the bacterial fermentate and evaporating the fermentate.
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