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公开(公告)号：EP0833658B1
公开(公告)日：2003-03-26
申请号：EP96918234.4
申请日：1996-06-06
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K2039/6068 , C07K14/575 , C07K2319/00
摘要： The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a fragment thereof, and a carrier protein. The present invention also relates to a method of enhancing the production performance of avians, by administering to a bird a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein. The present invention further relates to the above heterologous protein and fusion gene product, and to methods of producing the same.
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公开(公告)号：EP0804219B1
公开(公告)日：2002-07-17
申请号：EP95913576.5
申请日：1995-02-28
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K38/04 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K9/00 , C07K14/00 , C07K17/00 , A61K39/385 , C07K14/575
CPC分类号： C07K14/575 , A01K2217/05 , A61K39/0005 , A61K2039/6068 , C07K2319/00
摘要： The present invention relates to a method of accelerating the onset of puberty in avians, especially ratites and psittaciformes, by administering a heterologous protein comprising inhibin, or a fragment thereof, and a carrier protein. The present invention also relates to a method of increasing egg production in animals, particularly birds, more particularly ratites, via the administration of the heterologous protein. This invention further relates to the heterologous protein and a method for producing the heterologous protein. The heterologous protein can be either inhibin conjugated to the carrier protein or inhibin fused to the carrier protein. The method of producing the fused heterologous protein comprises inserting double stranded cDNA encoding inhibin, or a fragment thereof, into a vector which encodes a carrier protein such as maltose binding protein or bovine serum albumin. After inserting the vector into an expression system, the fused heterologous protein is expressed by the system. After purifying the expressed heterologous protein, an effective amount of the protein is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.
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公开(公告)号：EP0804219A1
公开(公告)日：1997-11-05
申请号：EP95913576.0
申请日：1995-02-28
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12N15 , A61K35 , A61K38 , A61K39 , A61P15 , C07H21 , C07K9 , C07K14 , C07K17 , C07K19 , C12N5 , C12P21 , C12R1
CPC分类号： C07K14/575 , A01K2217/05 , A61K39/0005 , A61K2039/6068 , C07K2319/00
摘要： The present invention relates to a method of accelerating the onset of puberty in avians, especially ratites and psittaciformes, by administering a heterologous protein comprising inhibin, or a fragment thereof, and a carrier protein. The present invention also relates to a method of increasing egg production in animals, particularly birds, more particularly ratites, via the administration of the heterologous protein. This invention further relates to the heterologous protein and a method for producing the heterologous protein. The heterologous protein can be either inhibin conjugated to the carrier protein or inhibin fused to the carrier protein. The method of producing the fused heterologous protein comprises inserting double stranded cDNA encoding inhibin, or a fragment thereof, into a vector which encodes a carrier protein such as maltose binding protein or bovine serum albumin. After inserting the vector into an expression system, the fused heterologous protein is expressed by the system. After purifying the expressed heterologous protein, an effective amount of the protein is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.
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公开(公告)号：EP0833658A1
公开(公告)日：1998-04-08
申请号：EP96918234.0
申请日：1996-06-06
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K2039/6068 , C07K14/575 , C07K2319/00
摘要： The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a fragment thereof, and a carrier protein. The present invention also relates to a method of enhancing the production performance of avians, by administering to a bird a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein. The present invention further relates to the above heterologous protein and fusion gene product, and to methods of producing the same.
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