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公开(公告)号：EP1648475B1
公开(公告)日：2007-09-12
申请号：EP04777982.2
申请日：2004-07-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , UNIVERSITY OF ALABAMA RESEARCH FOUNDATION , LOMA LINDA UNIVERSITY , WAKE FOREST UNIVERSITY
发明人： GLADWIN, Mark, T. , SCHECHTER, Alan, N. , LEFER, David, J. , PATEL, Rakesh, P. , HUNTER, Christian J., National Inst. of Health , POWER, Gordon, G. , KIM-SHAPIRO, Daniel, B. , PLUTA, Ryszard National Institutes of Health NINDS , OLDFIELD, Edward, H. , CANNON III, Richard, O.
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
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公开(公告)号：EP0833636B1
公开(公告)日：2006-08-23
申请号：EP96922478.1
申请日：1996-06-05
申请人： PLIVA D.D. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/166 , A61K31/4045 , A61K31/405 , A61K31/454 , A61K31/48 , A61K38/2257 , A61K31/40 , A61K2300/00
摘要： This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
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3.发明公开
公开(公告)号：EP1592789A2
公开(公告)日：2005-11-09
申请号：EP03800225.9
申请日：2003-12-24
申请人： Transgenrx, Inc. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12N15/00 , C12N15/63 , C12P21/00 , A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A23L15/00 , A23V2002/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K14/62 , C07K16/00 , C07K16/02 , C07K16/1063 , C07K16/26 , C07K2317/23 , C07K2317/34 , C12N15/85 , C12N2800/90 , C12N2830/003 , C12N2830/008 , C12N2830/90 , C12N2840/20 , Y02A50/407 , Y02A50/469 , A23V2300/21
摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
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公开(公告)号：EP0804219B1
公开(公告)日：2002-07-17
申请号：EP95913576.5
申请日：1995-02-28
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K38/04 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K9/00 , C07K14/00 , C07K17/00 , A61K39/385 , C07K14/575
CPC分类号： C07K14/575 , A01K2217/05 , A61K39/0005 , A61K2039/6068 , C07K2319/00
摘要： The present invention relates to a method of accelerating the onset of puberty in avians, especially ratites and psittaciformes, by administering a heterologous protein comprising inhibin, or a fragment thereof, and a carrier protein. The present invention also relates to a method of increasing egg production in animals, particularly birds, more particularly ratites, via the administration of the heterologous protein. This invention further relates to the heterologous protein and a method for producing the heterologous protein. The heterologous protein can be either inhibin conjugated to the carrier protein or inhibin fused to the carrier protein. The method of producing the fused heterologous protein comprises inserting double stranded cDNA encoding inhibin, or a fragment thereof, into a vector which encodes a carrier protein such as maltose binding protein or bovine serum albumin. After inserting the vector into an expression system, the fused heterologous protein is expressed by the system. After purifying the expressed heterologous protein, an effective amount of the protein is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.
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公开(公告)号：EP0804219A1
公开(公告)日：1997-11-05
申请号：EP95913576.0
申请日：1995-02-28
申请人： Agritech Technologies, Ltd. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： C12N15 , A61K35 , A61K38 , A61K39 , A61P15 , C07H21 , C07K9 , C07K14 , C07K17 , C07K19 , C12N5 , C12P21 , C12R1
CPC分类号： C07K14/575 , A01K2217/05 , A61K39/0005 , A61K2039/6068 , C07K2319/00
摘要： The present invention relates to a method of accelerating the onset of puberty in avians, especially ratites and psittaciformes, by administering a heterologous protein comprising inhibin, or a fragment thereof, and a carrier protein. The present invention also relates to a method of increasing egg production in animals, particularly birds, more particularly ratites, via the administration of the heterologous protein. This invention further relates to the heterologous protein and a method for producing the heterologous protein. The heterologous protein can be either inhibin conjugated to the carrier protein or inhibin fused to the carrier protein. The method of producing the fused heterologous protein comprises inserting double stranded cDNA encoding inhibin, or a fragment thereof, into a vector which encodes a carrier protein such as maltose binding protein or bovine serum albumin. After inserting the vector into an expression system, the fused heterologous protein is expressed by the system. After purifying the expressed heterologous protein, an effective amount of the protein is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.
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6.发明公开PROCESS FOR ACTIVATING REPRODUCTION OF SEASONAL BREEDING ANIMALS BY ADMINISTERING L-DIHYDROXYPHENYLALANINE (L-DOPA) 失效方法一种类型的，在一定季节女人耕畜BY转移L-羟基苯的激活。
公开(公告)号：EP0533818A1
公开(公告)日：1993-03-31
申请号：EP91912059.0
申请日：1991-06-11
IPC分类号： A61K31
CPC分类号： A61K31/405 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/216 , A61K2300/00
摘要： Procédé d'activation de la reproduction chez des vertébrés d'élevage saisonnier pendant des saisons au cours desquelles la reproduction n'a pas normalement lieu, consistant à administrer de la L-dihydroxyphenylalanine (L-DOPA), augmentant ainsi le niveau de L-DOPA dans le flux sanguin du vertébré jusqu'à un niveau d'activation de la reproduction. On peut également injecter une dose efficace de 5-HTP au vertébré suivie, après une certaine période, d'une injection d'une dose efficace de L-DOPA.
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公开(公告)号：EP4192494A1
公开(公告)日：2023-06-14
申请号：EP21853955.9
申请日：2021-08-06
申请人： La Jolla Institute for Immunology , The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人： BENEDICT, Christopher , KAMIL, Jeremy P. , SIDDIQUEY, Mohammed Nure Alam , SAPHIRE, Erica Ollmann , NORRIS, Michael
IPC分类号： A61K38/16 , C07K14/045 , G01N33/569
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公开(公告)号：EP4007772A1
公开(公告)日：2022-06-08
申请号：EP20848437.8
申请日：2020-07-28
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公开(公告)号：EP3856045A1
公开(公告)日：2021-08-04
申请号：EP19865150.7
申请日：2019-09-25
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公开(公告)号：EP3618850A1
公开(公告)日：2020-03-11
申请号：EP18794658.7
申请日：2018-05-01
IPC分类号： A61K38/17 , A61K45/06 , A61P27/02 , C07K14/705
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