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公开(公告)号：EP2935283B1
公开(公告)日：2019-02-27
申请号：EP13868947.6
申请日：2013-12-20
发明人： SELNICK, Harold, G. , LIU, Kun , MCEACHERN, Ernest, J. , KAUL, Ramesh , WEI, Zhongyong , WANG, Yaode , CHANG, Jiang
IPC分类号： C07D513/04 , A61P11/02 , A61K31/429
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公开(公告)号：EP2847199B1
公开(公告)日：2017-10-25
申请号：EP13787989.6
申请日：2013-05-03
发明人： SELNICK, Harold, G. , LI, Wenping , HOSTETLER, Eric , LIU, Kun , MCEACHERN, Ernest, J. , ZHOU, Yuanxi , WEI, Zhongyong , MU, Changwei , WANG, Yaode , CHANG, Jiang
IPC分类号： C07D513/04 , C07H9/06 , A61K31/429 , A61P25/00
CPC分类号： C07D513/04 , C07B59/005 , C07B2200/05 , C07H9/06
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公开(公告)号：EP2726468B1
公开(公告)日：2017-04-12
申请号：EP12805139.8
申请日：2012-06-27
发明人： LI, Tong-Shuang , MCEACHERN, Ernest, J. , VOCADLO, David, J. , ZHOU, Yuanxi , SELNICK, Harold, G.
IPC分类号： C07D263/58 , A61K31/423 , C07D277/82 , C12Q1/34 , G01N33/50
CPC分类号： C07D277/60 , C07D263/52 , C07D263/58 , C07D277/82 , C12Q1/37 , G01N2333/924 , G01N2500/04
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公开(公告)号：EP2744338A1
公开(公告)日：2014-06-25
申请号：EP12823924.1
申请日：2012-08-10
CPC分类号： C07D263/58 , A61K31/423 , A61K31/428 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04
摘要： The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.
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公开(公告)号：EP3389658A1
公开(公告)日：2018-10-24
申请号：EP16876528.7
申请日：2016-12-14
IPC分类号： A61K31/454 , C07D471/14
CPC分类号： C07D417/06 , C07D409/06 , C07D417/14
摘要： The present invention is directed to thiazolyl piperidine compounds which are inhibitors of O-GlcNAcase. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which O-GlcNAcase is involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which O-GlcNAcase is involved.
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公开(公告)号：EP2890676A1
公开(公告)日：2015-07-08
申请号：EP13834078.1
申请日：2013-08-29
IPC分类号： C07D207/14 , A61K31/40 , A61K31/428 , A61K31/4439 , A61P25/28 , C07D401/06 , C07D417/06 , C07H13/02 , C12N9/24
CPC分类号： C07D417/06 , C07D207/14 , C07D401/06 , C07D401/08
摘要： The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译： 本发明提供了用于抑制糖苷酶的化合物，化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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公开(公告)号：EP2726468A1
公开(公告)日：2014-05-07
申请号：EP12805139.8
申请日：2012-06-27
发明人： LI, Tong-Shuang , MCEACHERN, Ernest, J. , VOCADLO, David, J. , ZHOU, Yuanxi , SELNICK, Harold, G.
IPC分类号： C07D263/58 , A61K31/423 , C07D277/82 , C12Q1/34 , G01N33/50
CPC分类号： C07D277/60 , C07D263/52 , C07D263/58 , C07D277/82 , C12Q1/37 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号：EP3389658B1
公开(公告)日：2020-11-25
申请号：EP16876528.7
申请日：2016-12-14
IPC分类号： A61K31/454 , A61P25/16 , A61P25/18 , A61P25/28 , A61P35/00 , C07D417/06 , C07D417/14
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公开(公告)号：EP2890676B1
公开(公告)日：2018-12-05
申请号：EP13834078.1
申请日：2013-08-29
IPC分类号： C07D207/14 , A61K31/40 , A61K31/428 , A61K31/4439 , A61P25/28 , C07D401/06 , C07D417/06 , C07H13/02 , C12N9/24
CPC分类号： C07D417/06 , C07D207/14 , C07D401/06 , C07D401/08
摘要： The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号：EP2744338B1
公开(公告)日：2016-04-27
申请号：EP12823924.1
申请日：2012-08-10
IPC分类号： A61K31/42 , C07D413/04 , C07D417/04 , C07D263/58 , C07D277/60 , C07D277/82
CPC分类号： C07D263/58 , A61K31/423 , A61K31/428 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04
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