公开(公告)号：EP1994983A1

公开(公告)日：2008-11-26

申请号：EP07009638.3

申请日：2007-05-14

Applicant: Almquest AB

Inventor： Almqvist, Fredrik ,  Basu, Basudeb

IPC: B01J23/44 ,  B01J37/02 ,  B01J37/30 ,  C07C69/612 ,  C07C69/618

CPC classification number: C07C67/343 ,  B01J23/44 ,  B01J31/08 ,  B01J31/165 ,  B01J37/06 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C1/321 ,  C07C17/263 ,  C07C37/18 ,  C07C41/30 ,  C07C2523/44 ,  C07C2531/08 ,  C07C2603/24 ,  C07D213/61 ,  C07D401/04 ,  C07D413/04 ,  C07D491/147 ,  C07C15/14 ,  C07C25/18 ,  C07C69/618 ,  C07C69/65 ,  C07C43/205 ,  C07C39/15

Abstract: 1. A method of producing a heterogeneous catalyst suitable for catalyzing Heck, Suzuki-Miyaura and Buchwald-Hartwig reactions, comprising the steps of:
a) providing a porous carrier, said porous carrier consisting of a core and a plurality of ion exchange groups covalently bonded to the surface of said core, where at least 90 % of the ions bound to said carrier are formate ions;
b) providing a palladium (II) salt;
c) suspending said carrier in an organic solvent thereby obtaining a suspension;
d) adding said palladium salt to said suspension and allowing the resulting mixture to react at a temperature within the range of 30 - 70 °C until said carrier has turned black;
e) washing said carrier in water; and
f) drying said carrier under vacuum;

characterised in that
the resulting carrier subsequently is resuspended in dimethyl formamide and heated under inert atmosphere to at least 90 °C for 2 hours followed by washing with a polar solvent and drying.
The invention also relates to a catalyst produced by the method and to processes where the catalyst is used for catalysing Heck, Suzuki-Miyaura, and Buchwald-Hartwig reactions.

Abstract translation: 1，一种生产适用于催化的Heck，铃木 - 宫浦和布赫瓦尔德 - 哈特维希反应，包括如下步骤的非均相催化剂的方法：a）提供多孔载体，所述芯部和离子交换基团的共价多元化的多孔载体由......组成 结合到所述芯，其中至少90％的结合至所述载体的离子是甲酸根离子的表面上; 盐b）提供钯（II）; c）中悬浮于有机溶剂中，所述载体，从而得到悬浮液; d）将所说的钯盐对所述悬浮液和使​​所得混合物在30范围内的温度下进行反应 - 直到所述载体变黑70℃; E）洗涤所述水载体; 和f）干燥所述在真空下载体; DASS随后再悬浮于二甲基甲酰胺和惰性气氛下加热到至少90℃，然后进行洗涤用极性溶剂和干燥2小时得到的载体。 因此，本发明涉及通过所述方法和到当催化剂是用于催化的Heck，铃木 - 宫浦，和布赫瓦尔德 - 哈特维希反应过程中产生的催化剂。