公开(公告)号：EP3122707B1

公开(公告)日：2018-04-25

申请号：EP15716307.2

申请日：2015-03-27

Applicant: Dow Global Technologies LLC ,  Dow AgroSciences LLC

Inventor： HANLEY, Patrick S. ,  WHITEKER, Gregory T. ,  OBER, Matthias S. ,  KRUPER, William J. Jr. ,  KRASOVSKIY, Arkady L.

IPC: C07B37/04 ,  C07C67/343 ,  C07C41/30 ,  C07C1/32 ,  C07C45/70 ,  C07C211/45 ,  C07C231/12 ,  C07C233/00 ,  C07D263/54 ,  C07C253/30 ,  C07D213/127 ,  C07D213/16

CPC classification number: C07C1/322 ,  C07B37/04 ,  C07C1/321 ,  C07C15/14 ,  C07C17/263 ,  C07C22/04 ,  C07C22/08 ,  C07C41/30 ,  C07C45/70 ,  C07C67/343 ,  C07C211/45 ,  C07C231/12 ,  C07C233/00 ,  C07C253/30 ,  C07C2531/22 ,  C07C2531/24 ,  C07C2531/28 ,  C07D213/127 ,  C07D213/16 ,  C07D263/54 ,  C07C233/65 ,  C07C255/50 ,  C07C43/205 ,  C07C49/784 ,  C07C69/76

Abstract: In one aspect, there is provided a method of coupling a first aromatic compound having a fluorosulfonate substituent to a second aromatic compound having a boron-containing substituent. In another aspect, there is provided a method of coupling a first aromatic compound having a hydroxyl substituent to a second aromatic compound having a boron-containing substituent in a one-pot reaction.

公开(公告)号：EP2958887B1

公开(公告)日：2018-03-07

申请号：EP14705358.1

申请日：2014-02-20

Applicant: Centro de Investigación Príncipe Felipe ,  Instituto de Salud Carlos III ,  Universidad Católica de Valencia "San Vicente Mártir" ,  Universitat de València

Inventor： GALLEGO SALA, José ,  FUSTERO LARDIÉS, Santos ,  ALCAMÍ PERTEJO, José ,  GONZÁLEZ BULNES, Luis ,  IBAÑEZ SÁNCHEZ, Ignacio ,  CATALÁN MUÑOZ, Silvia ,  PRADO MARTÍN, Silvia ,  CANTERO CAMACHO, Ángel ,  BARRIO FERNÁNDEZ, Pablo

IPC: C07C213/02 ,  C07C217/60 ,  A61K31/137 ,  A61K31/14 ,  A61P31/14 ,  A61P31/18 ,  A61P31/04 ,  A61P35/00

CPC classification number: C07D403/14 ,  A61K31/137 ,  A61K31/14 ,  C07C15/14 ,  C07C211/09 ,  C07C217/60 ,  C07D235/06 ,  C07D237/08 ,  C07D239/26 ,  C07D241/04 ,  C07D401/14 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/465

Abstract: The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their ability to interact with an internal RNA loop and to mimic a protein α-helix these compounds are effective in the treatment and/or prevention of HIV-1 (Human Immunodeficiency Virus-1) infection and other diseases such as those caused by other RNA viruses and by gram-positive and gram-negative bacteria, or infectious or chronic diseases responsive to inhibition of DNA transcription, or infectious or chronic diseases where these compounds can be used to modulate the function of RNA internal loops, or infectious or chronic diseases where these compounds can be used as agonists or inhibitors of α-helical proteins in interaction with other biomolecules.

公开(公告)号：EP3233769A4

公开(公告)日：2018-01-24

申请号：EP15870658

申请日：2015-12-02

Applicant: EXXONMOBIL CHEMICAL PATENTS INC

Inventor： SALCICCIOLI MICHAEL ,  DAKKA JIHAD M ,  DE SMIT EMIEL ,  SANGAR NEERAJ ,  WEIGEL SCOTT J ,  RAMAN SUMATHY ,  HELTON TERRY E ,  DECAUL LORENZO C ,  ELIA CHRISTINE N ,  BAI CHUANSHENG ,  GHOSE RANJITA

IPC: C07C5/27 ,  C07C2/74 ,  C07C2/86 ,  C07C5/367 ,  C07C13/28 ,  C07C15/14

CPC classification number: C07C2/74 ,  C07C2/864 ,  C07C5/2737 ,  C07C5/367 ,  C07C2521/02 ,  C07C2521/04 ,  C07C2529/08 ,  C07C2529/18 ,  C07C2529/40 ,  C07C2529/70 ,  C07C15/14 ,  C07C13/28

Abstract: A process is described for converting at least one isomer of a dialkyl- substituted biphenyl compound, such as at least one 2,X' dialkylbiphenyl isomer (where X' is 2', 3' and/or 4'), into at least one different isomer, 3,3', 3,4' and/or 4,4' dialkylbiphenyl isomer. The process comprises contacting a feed comprising the dialkyl-substituted biphenyl compound isomer with an acid catalyst under isomerization conditions.

公开(公告)号：EP3114101A4

公开(公告)日：2017-03-29

申请号：EP14884331

申请日：2014-08-11

Applicant: EXXONMOBIL CHEMICAL PATENTS INC

Inventor： DAKKA JIHAD M ,  DECAUL LORENZO C ,  DE SMIT EMIEL ,  HELTON TERRY E ,  SALCICCIOLI MICHAEL ,  SANGAR NEERAJ ,  WEIGEL SCOTT J

IPC: C07C2/02 ,  B01J29/08 ,  B01J29/10 ,  B01J29/12 ,  B01J29/14 ,  B01J29/18 ,  B01J29/22 ,  B01J29/24 ,  B01J29/70 ,  B01J29/74 ,  B01J29/76 ,  C07C2/74 ,  C07C5/367 ,  C07C7/20 ,  C07C51/16 ,  C07C51/265 ,  C07C51/50 ,  C07C67/08

CPC classification number: C07C2/74 ,  B01J29/088 ,  B01J29/106 ,  B01J29/12 ,  B01J29/126 ,  B01J29/146 ,  B01J29/185 ,  B01J29/22 ,  B01J29/24 ,  B01J29/7057 ,  B01J29/7084 ,  B01J29/7415 ,  B01J29/7469 ,  B01J29/7615 ,  B01J29/7669 ,  B01J35/023 ,  B01J35/026 ,  B01J2029/081 ,  B01J2229/186 ,  B01J2229/42 ,  C07C5/367 ,  C07C51/265 ,  C07C67/08 ,  C07C2521/12 ,  C07C2529/08 ,  C07C2529/12 ,  C07C2529/22 ,  C07C2529/74 ,  C07C2529/80 ,  Y02P20/52 ,  C07C63/331 ,  C07C69/76 ,  C07C13/28 ,  C07C15/14

Abstract: This invention relates to process for producing biphenyl esters, the process comprising: (a) contacting a feed comprising toluene, xylene or mixtures thereof with hydrogen in the presence of a hydroalkylation catalyst to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluene, wherein the hydroalkylation catalyst comprises: 1) binder present at 40 wt % or less (based upon weight of final catalyst composition), 2) a hydrogenation component present at 0.2 wt % or less (based upon weight of final catalyst composition), and 3) an acidic component comprising a molecular sieve having a twelve membered (or larger) ring pore opening, channel or pocket and a largest pore dimension of 6.0 angstroms or more present at 60 wt % or more, (based upon weight of final catalyst composition); (b) dehydrogenating the hydroalkylation reaction product using a dehydrogenation catalyst to produce a dehydrogenation reaction product comprising a mixture of methyl-substituted biphenyl compounds; (c) contacting at the dehydrogenation reaction product with an oxidizing gas to convert the methyl-substituted biphenyl compounds to biphenyl carboxylic acids; and (d) reacting the biphenyl carboxylic acids with one or more C1 to C14 alcohols to produce biphenyl esters.

Abstract translation: 本发明涉及生产联苯酯的方法，该方法包括：（a）使包含甲苯，二甲苯或其混合物的进料与氢气在加氢烷基化催化剂存在下接触以产生包含（甲基环己基）甲苯的加氢烷基化反应产物，其中 加氢烷基化催化剂包含：1）以40wt％或更低（基于最终催化剂组合物的重量计）存在的粘合剂，2）以0.2wt％或更低（基于最终催化剂组合物的重量计）存在的氢化组分，和3） 酸性组分，其包含具有十二元（或更大）环孔开口，通道或袋并且以60重量％或更多存在的6.0埃或更大的最大孔尺寸（基于最终催化剂组合物的重量）的分子筛; （b）使用脱氢催化剂使加氢烷基化反应产物脱氢以产生包含甲基取代的联苯化合物的混合物的脱氢反应产物; （c）在脱氢反应产物与氧化气体接触以将甲基取代的联苯化合物转化为联苯羧酸; 和（d）使联苯羧酸与一种或多种C1-C14醇反应以生产联苯酯。

公开(公告)号：EP2970050A1

公开(公告)日：2016-01-20

申请号：EP14772911.5

申请日：2014-03-07

Applicant: ExxonMobil Chemical Patents Inc.

Inventor： DAKKA, Jihad, M. ,  BAI, Chuansheng ,  TANKE, James, J. ,  DE MARTIN, Gregory, J. ,  VAN NOSTRAND, Mary, T. ,  SALCICCIOLI, Michael ,  KHEIR, Ali, A. ,  SANGAR, Neeraj

IPC: C07C7/20 ,  C07C15/16

CPC classification number: C07C67/08 ,  C07C2/74 ,  C07C5/367 ,  C07C2521/04 ,  C07C2521/08 ,  C07C2521/18 ,  C07C2523/42 ,  C07C2523/62 ,  C07C2529/76 ,  C07C2601/14 ,  C07C69/76 ,  C07C15/14 ,  C07C13/28

Abstract: In a process for producing a methyl-substituted biphenyl compound, at least one methyl-substituted cyclohexylbenzene compound of the formula: wherein each of m and n is independently an integer from 1 to 3, is contacted with a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising at least one methyl-substituted biphenyl compound. The dehydrogenation catalyst comprises an element or compound thereof from Group 10 of the Periodic Table of Elements deposited on a refractory support, such as alumina.

Abstract translation: 在用于制造一个甲基substituiertem联苯化合物，式中的至少一个甲基substituiertem环己基苯化合物的方法：worin每个m和n为整数unabhängig从1至3，用脱氢催化剂有效地产生的条件下接触 脱氢反应产物包含至少一种甲基 - 取代的联苯化合物。 如氧化铝：从沉积在耐火载体，颜色元素周期表第10族元素或化合物的脱氢催化剂包含物。

公开(公告)号：EP2970045A1

公开(公告)日：2016-01-20

申请号：EP14775804.9

申请日：2014-03-07

Applicant: ExxonMobil Chemical Patents Inc.

Inventor： DAKKA, Jihad, M. ,  DECAUL, Lorenzo, C. ,  DEFLORIO, Victor

IPC: C07C2/64 ,  C07C13/28

CPC classification number: C07C5/367 ,  B01J29/0325 ,  B01J29/085 ,  B01J29/12 ,  B01J29/14 ,  B01J29/7057 ,  B01J29/7084 ,  B01J29/7415 ,  B01J29/7469 ,  B01J29/7615 ,  B01J29/7669 ,  C07C2/74 ,  C07C51/265 ,  C07C67/08 ,  C07C2521/04 ,  C07C2521/08 ,  C07C2523/14 ,  C07C2523/42 ,  C07C2529/70 ,  C07C2529/74 ,  C07C2601/14 ,  Y02P20/52 ,  C07C13/28 ,  C07C15/14 ,  C07C63/331 ,  C07C69/76

Abstract: In a process for producing methyl-substituted biphenyl compounds, a feed comprising at least one aromatic hydrocarbon selected from the group consisting of toluene, xylene and mixtures thereof is contacted with hydrogen in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluenes and/or (dimethylcyclohexyl)xylenes together with dialkylated C
21 + compounds. At least part of the dialkylated C
21 + compounds is then removed from the hydroalkylation reaction product to produce a dehydrogenation feed; and at least part of the dehydrogenation feed is dehydrogenated in the presence of a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising a mixture of methyl-substituted biphenyl compounds.

Abstract translation: 在用于生产甲基substituiertem联苯化合物的方法中，包括至少一个芳族烃基选自甲苯，二甲苯和它们的混合物与氢气在加氢烷基化催化剂的存在下在有效产生加氢烷基化反应进料的条件下接触选定 包含产物（甲基环己基）甲苯和/或（二甲基）二甲苯连同二烷基化C21 +的化合物。 至少二烷基化C21 +的化合物的一部分，然后从加氢烷基化反应产物以产生脱氢进料除去; 和脱氢进料的至少一部分在脱氢催化剂的有效产生脱氢反应产物包含甲基 - 联苯substituiertem化合物的混合物的条件下的存在下脱氢。

公开(公告)号：EP2172470A4

公开(公告)日：2011-08-31

申请号：EP08765824

申请日：2008-06-18

Applicant: SUMITOMO CHEMICAL CO

Inventor： ASAUMI TAKU ,  KAMIKAWA TAKASHI

IPC: C07F7/10 ,  C07C15/14 ,  C07C39/15 ,  C07C43/164 ,  C07C43/205 ,  C07C49/784 ,  C07D239/28 ,  C07D333/02 ,  C07F7/12 ,  C07F15/04 ,  C08F4/70

CPC classification number: C07C39/15 ,  C07C1/26 ,  C07C45/72 ,  C07C49/84 ,  C07C2523/06 ,  C07C2531/22 ,  C07D239/28 ,  C07D333/02 ,  C07F7/0812 ,  C07F7/0814 ,  C07C15/14 ,  C07C49/784

公开(公告)号：EP1692075A4

公开(公告)日：2009-12-23

申请号：EP04811935

申请日：2004-11-24

Applicant: LEFENFELD MICHAEL ,  DYE JAMES L

Inventor： LEFENFELD MICHAEL ,  DYE JAMES L

IPC: C04B35/14 ,  B01J21/08 ,  B01J21/12 ,  B01J21/14 ,  B01J23/04 ,  B01J35/00 ,  B01J37/02 ,  B01J37/08 ,  C01B3/02 ,  C01B3/08 ,  C01B6/24 ,  C01B33/12 ,  C01B33/32 ,  C04B35/16 ,  C07C5/00 ,  C07C17/25 ,  C07F1/02

CPC classification number: B01J35/002 ,  B01J20/02 ,  B01J20/103 ,  B01J20/28047 ,  B01J20/28078 ,  B01J20/28097 ,  B01J20/281 ,  B01J20/291 ,  B01J20/3078 ,  B01J20/3204 ,  B01J20/3236 ,  B01J23/04 ,  B01J37/023 ,  B01J37/08 ,  B01J2220/42 ,  B01J2220/54 ,  B01J2220/56 ,  B01J2220/58 ,  C01B3/001 ,  C01B3/06 ,  C07C2/861 ,  C07C2/868 ,  C07D333/76 ,  Y02E60/324 ,  Y02E60/36 ,  C07C15/18 ,  C07C15/14

公开(公告)号：EP1707263B1

公开(公告)日：2009-02-25

申请号：EP06006696.6

申请日：2006-03-30

Applicant: TOSOH CORPORATION

Inventor： Ishikwa, Shinichi ,  Awano, Hiroshi ,  Yano, Hirokazu ,  Eguchi, Hisao

IPC: B01J31/18 ,  B01J31/24 ,  C07B37/04 ,  C07F15/04

CPC classification number: C07C41/30 ,  B01J31/1805 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2531/847 ,  C07B37/04 ,  C07C1/321 ,  C07C17/263 ,  C07C43/215 ,  C07C253/30 ,  C07F15/045 ,  C07C15/52 ,  C07C15/14 ,  C07C22/08 ,  C07C255/54 ,  C07C43/205

公开(公告)号：EP1994983A1

公开(公告)日：2008-11-26

申请号：EP07009638.3

申请日：2007-05-14

Applicant: Almquest AB

Inventor： Almqvist, Fredrik ,  Basu, Basudeb

IPC: B01J23/44 ,  B01J37/02 ,  B01J37/30 ,  C07C69/612 ,  C07C69/618

CPC classification number: C07C67/343 ,  B01J23/44 ,  B01J31/08 ,  B01J31/165 ,  B01J37/06 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C1/321 ,  C07C17/263 ,  C07C37/18 ,  C07C41/30 ,  C07C2523/44 ,  C07C2531/08 ,  C07C2603/24 ,  C07D213/61 ,  C07D401/04 ,  C07D413/04 ,  C07D491/147 ,  C07C15/14 ,  C07C25/18 ,  C07C69/618 ,  C07C69/65 ,  C07C43/205 ,  C07C39/15

Abstract: 1. A method of producing a heterogeneous catalyst suitable for catalyzing Heck, Suzuki-Miyaura and Buchwald-Hartwig reactions, comprising the steps of:
a) providing a porous carrier, said porous carrier consisting of a core and a plurality of ion exchange groups covalently bonded to the surface of said core, where at least 90 % of the ions bound to said carrier are formate ions;
b) providing a palladium (II) salt;
c) suspending said carrier in an organic solvent thereby obtaining a suspension;
d) adding said palladium salt to said suspension and allowing the resulting mixture to react at a temperature within the range of 30 - 70 °C until said carrier has turned black;
e) washing said carrier in water; and
f) drying said carrier under vacuum;

characterised in that
the resulting carrier subsequently is resuspended in dimethyl formamide and heated under inert atmosphere to at least 90 °C for 2 hours followed by washing with a polar solvent and drying.
The invention also relates to a catalyst produced by the method and to processes where the catalyst is used for catalysing Heck, Suzuki-Miyaura, and Buchwald-Hartwig reactions.

Abstract translation: 1，一种生产适用于催化的Heck，铃木 - 宫浦和布赫瓦尔德 - 哈特维希反应，包括如下步骤的非均相催化剂的方法：a）提供多孔载体，所述芯部和离子交换基团的共价多元化的多孔载体由......组成 结合到所述芯，其中至少90％的结合至所述载体的离子是甲酸根离子的表面上; 盐b）提供钯（II）; c）中悬浮于有机溶剂中，所述载体，从而得到悬浮液; d）将所说的钯盐对所述悬浮液和使​​所得混合物在30范围内的温度下进行反应 - 直到所述载体变黑70℃; E）洗涤所述水载体; 和f）干燥所述在真空下载体; DASS随后再悬浮于二甲基甲酰胺和惰性气氛下加热到至少90℃，然后进行洗涤用极性溶剂和干燥2小时得到的载体。 因此，本发明涉及通过所述方法和到当催化剂是用于催化的Heck，铃木 - 宫浦，和布赫瓦尔德 - 哈特维希反应过程中产生的催化剂。