-
1.发明公开Lipid formulated compositions and mehods for inhibiting expression of a gene from the ebola virus 审中-公开脂质制剂的组合物和方法，用于从埃博拉病毒抑制的基因的表达
公开(公告)号：EP2810643A2
公开(公告)日：2014-12-10
申请号：EP14168745.9
申请日：2010-08-13
IPC分类号： A61K9/127 , A61K48/00 , A61K31/7088 , C12N15/113 , C12N15/11
CPC分类号： A61K48/0075 , A61K47/22 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/32
摘要： The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译： 本发明涉及一种脂质配制的双链核糖核酸（dsRNA），用于抑制从所述埃博拉病毒的基因的表达。
-
2.发明授权
公开(公告)号：EP2589660B1
公开(公告)日：2014-11-26
申请号：EP12178468.0
申请日：2008-03-25
申请人： Alnylam Pharmaceuticals Inc. , Government Of The United States As Represented By Secretary Of The Army
发明人： Bavari, Sina , Warfield, Kelly Lyn , Tan, Pamela , Borodovsky, Anna , Novobrantseva, Tatiana , De Fougerolles, Antonin
IPC分类号： C12N15/11 , C07H21/00 , A61K31/713 , C12N15/113
CPC分类号： C12N15/1131 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531
-
3.发明公开Compositions and methods for inhibiting expression of a gene from the ebola 审中-公开Zusammensetzungen und Verfahren zur Hemmung der Expression eines Gens von Ebola
公开(公告)号：EP2905336A1
公开(公告)日：2015-08-12
申请号：EP14194586.5
申请日：2008-03-25
申请人： Alnylam Pharmaceuticals Inc. , Government Of The United States As Represented By Secretary Of The Army
发明人： Bavari, Sina , Warfield, Kelly Lyn , Tan, Pamela , Borodovsky, Anna , Novobrantseva, Tatiana , De Fougerolles, Antonin
IPC分类号： C12N15/11 , C07H21/00 , A61K31/713 , C12N15/113
CPC分类号： C12N15/1131 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译： 本发明涉及用于抑制埃博拉病毒基因表达的双链核糖核酸（dsRNA）。
-
公开(公告)号：EP4365291A3
公开(公告)日：2024-08-14
申请号：EP24152344.8
申请日：2016-06-10
发明人： Borodovsky, Anna
IPC分类号： A61K31/7105 , A61K39/00 , A61K31/713 , A61K39/395 , C07K16/18 , C12N15/113 , A61P43/00 , A61K9/00 , A61P7/00 , A61P21/00
CPC分类号： A61K9/0019 , A61K31/713 , C07K16/18 , C12N15/113 , C12N2310/1420130101 , C12N2310/31520130101 , C12N2310/32120130101 , C12N2310/32220130101 , C12N2310/351520130101 , A61K2039/50520130101 , A61K31/7105 , Y02A50/30
摘要： The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.
-
公开(公告)号：EP4365291A2
公开(公告)日：2024-05-08
申请号：EP24152344.8
申请日：2016-06-10
发明人： Borodovsky, Anna
IPC分类号： C12N15/113
CPC分类号： A61K9/0019 , A61K31/713 , C07K16/18 , C12N15/113 , C12N2310/1420130101 , C12N2310/31520130101 , C12N2310/32120130101 , C12N2310/32220130101 , C12N2310/351520130101 , A61K2039/50520130101 , A61K31/7105 , Y02A50/30
摘要： The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.
-
公开(公告)号：EP3798306A1
公开(公告)日：2021-03-31
申请号：EP20200586.4
申请日：2014-12-12
IPC分类号： C12N15/113 , C12N15/11 , A61P25/28 , A61P43/00 , A61P37/06 , A61K31/712 , A61K38/12 , A61K31/713
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of complement component C3 in a cell, wherein said dsRNA comprises a sense strand and an antisense strand, wherein each strand comprises 15-30 nucleotides and said strands form a double-stranded region, and wherein the antisense strand comprising at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the following antisense sequences:
a. GAGAGAAGACCUUGACCACGUAG (SEQ ID NO:282);
b. UAGAGAAGACCUUGACCACGUAG (SEQ ID NO:267);
c. AGAGAGAAGACCUUGACCACGUA (SEQ ID NO:266);
d. AGAGAAGACCUUGACCACGUAGG (SEQ ID NO:299); and wherein at least one nucleotide in said dsRNA comprises a modification.-
7.发明公开Lipid formulated compositions and mehods for inhibiting expression of a gene from the ebola virus 审中-公开脂质制剂的组合物和方法，用于从埃博拉病毒抑制的基因的表达
公开(公告)号：EP2810643A3
公开(公告)日：2015-03-11
申请号：EP14168745.9
申请日：2010-08-13
IPC分类号： A61K9/127 , A61K48/00 , A61K31/7088 , C12N15/113 , C12N15/11
CPC分类号： A61K48/0075 , A61K47/22 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/32
摘要： The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
-
8.发明公开Compositions and methods for inhibiting expression of a gene from the Ebola 有权Zusammensetzungen und Verfahren zur Hemmung der Ebola-Genexpression
公开(公告)号：EP2589660A1
公开(公告)日：2013-05-08
申请号：EP12178468.0
申请日：2008-03-25
申请人： Alnylam Pharmaceuticals Inc. , Government Of The United States As Represented By Secretary Of The Army
发明人： Bavari, Sina , Warfield, Kelly Lyn , Tan, Pamela , Borodovsky, Anna , Novobrantseva, Tatiana , De Fougerolles, Antonin
IPC分类号： C12N15/11 , C07H21/00 , A61K31/713 , C12N15/113
CPC分类号： C12N15/1131 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译： 本发明涉及用于抑制埃博拉病毒基因表达的双链核糖核酸（dsRNA）。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.024 秒)
