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1.发明公开Compositions and methods for inhibiting expression of factor VII gene 审中-公开Zusammensetzungen und Verfahren zur Hemmung der Faktor VII-Genexpression
公开(公告)号：EP2848688A1
公开(公告)日：2015-03-18
申请号：EP14179386.9
申请日：2008-12-10
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
摘要翻译： 本发明涉及用于抑制因子VII基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：EP2617828B1
公开(公告)日：2014-09-24
申请号：EP12196963.8
申请日：2008-12-10
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
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公开(公告)号：EP2899278A1
公开(公告)日：2015-07-29
申请号：EP14197031.9
申请日：2005-03-11
发明人： De Fougerolles, Antonin , Frank-Kamenetsky, Maria , Manoharan, Muthiah , Rajeev, Kallanthottahil G. , Hadwiger, Philipp
IPC分类号： C12N15/113 , A61K31/713 , A61K31/712 , C07K14/475 , A61K31/7088 , A61K48/00 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/48
CPC分类号： C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
摘要： The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.
摘要翻译： 本发明的特征涉及用于调节血管内皮生长因子（VEGF）表达的化合物，组合物和方法，例如通过RNA干扰（RNAi）机制。 化合物和组合物包括可以未修饰或化学修饰的iRNA试剂。
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公开(公告)号：EP2617828A1
公开(公告)日：2013-07-24
申请号：EP12196963.8
申请日：2008-12-10
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/314 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521 , C12Y304/21021
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
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5.发明公开Compositions and methods for inhibiting expression of a gene from the ebola 审中-公开Zusammensetzungen und Verfahren zur Hemmung der Expression eines Gens von Ebola
公开(公告)号：EP2905336A1
公开(公告)日：2015-08-12
申请号：EP14194586.5
申请日：2008-03-25
申请人： Alnylam Pharmaceuticals Inc. , Government Of The United States As Represented By Secretary Of The Army
发明人： Bavari, Sina , Warfield, Kelly Lyn , Tan, Pamela , Borodovsky, Anna , Novobrantseva, Tatiana , De Fougerolles, Antonin
IPC分类号： C12N15/11 , C07H21/00 , A61K31/713 , C12N15/113
CPC分类号： C12N15/1131 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译： 本发明涉及用于抑制埃博拉病毒基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：EP2636739B1
公开(公告)日：2014-12-10
申请号：EP13156812.3
申请日：2005-03-11
发明人： De Fougerolles, Antonin , Frank-Kamenetsky, Maria , Manoharan, Muthiah , Rajeev, Kallanthottahil G. , Hadwiger, Philipp
IPC分类号： C12N15/11 , A61K31/713 , A61K31/712 , C07K14/475 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/48 , C12N15/113 , A61K48/00 , A61K31/7088 , A61K9/00
CPC分类号： C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
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公开(公告)号：EP2365077B1
公开(公告)日：2013-05-08
申请号：EP11001330.7
申请日：2005-03-11
发明人： De Fougerolles, Antonin , Frank-Kamenetsky, Maria , Manoharan, Muthiah , Rajeev, Kallanthottahil G. , Hadwiger, Philipp
IPC分类号： C12N15/11 , C12N15/113 , C07K14/475 , A61K31/713 , A61K31/712 , A61K47/48 , A61K31/7088 , A61K48/00 , A61K47/02 , A61K47/10 , A61K47/12
CPC分类号： C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
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8.发明公开Lipid formulated compositions and mehods for inhibiting expression of a gene from the ebola virus 审中-公开脂质制剂的组合物和方法，用于从埃博拉病毒抑制的基因的表达
公开(公告)号：EP2810643A2
公开(公告)日：2014-12-10
申请号：EP14168745.9
申请日：2010-08-13
IPC分类号： A61K9/127 , A61K48/00 , A61K31/7088 , C12N15/113 , C12N15/11
CPC分类号： A61K48/0075 , A61K47/22 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/32
摘要： The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译： 本发明涉及一种脂质配制的双链核糖核酸（dsRNA），用于抑制从所述埃博拉病毒的基因的表达。
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9.发明授权
公开(公告)号：EP2589660B1
公开(公告)日：2014-11-26
申请号：EP12178468.0
申请日：2008-03-25
申请人： Alnylam Pharmaceuticals Inc. , Government Of The United States As Represented By Secretary Of The Army
发明人： Bavari, Sina , Warfield, Kelly Lyn , Tan, Pamela , Borodovsky, Anna , Novobrantseva, Tatiana , De Fougerolles, Antonin
IPC分类号： C12N15/11 , C07H21/00 , A61K31/713 , C12N15/113
CPC分类号： C12N15/1131 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531
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公开(公告)号：EP2365077A1
公开(公告)日：2011-09-14
申请号：EP11001330.7
申请日：2005-03-11
发明人： De Fougerolles, Antonin , Frank-Kamenetski, Maria , Manoharan, Muthiah , Rajeev, Kallanthottahil G. , Hadwiger, Philipp
IPC分类号： C12N15/11 , C07K14/475 , A61K31/713 , A61K31/712 , A61K47/48 , A61K48/00 , A61K47/02 , A61K47/10 , A61K47/12 , C12N15/113
CPC分类号： C12N15/1136 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/549 , A61K47/551 , A61K47/60 , A61K48/00 , C07K14/475 , C12N2310/14 , C12N2310/3515 , C12N2310/533 , C12N2320/30 , C12N2320/32
摘要： The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically modified.
摘要翻译： 本发明的特征涉及用于调节血管内皮生长因子（VEGF）表达的化合物，组合物和方法，例如通过RNA干扰（RNAi）机制。 化合物和组合物包括可以未修饰或化学修饰的iRNA试剂。
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