公开(公告)号：EP1229825B1

公开(公告)日：2012-06-20

申请号：EP00980533.4

申请日：2000-11-17

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： FAUPEL, Mark, L. ,  KUMAR, Krishna ,  FARQUHAR, David ,  VREEKE, Mark ,  SMITH, Alan ,  HATCH, Michael ,  WOODS, Teresa

IPC分类号： A61B5/1486

CPC分类号： A61B5/1486

摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

公开(公告)号：EP1098589B1

公开(公告)日：2006-02-22

申请号：EP99935678.5

申请日：1999-07-20

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： SMITH, Alan ,  DELCHER, Harry, K. ,  EPPSTEIN, Jonathan, A. ,  FARQUHAR, David ,  HATCH, Michael, R. ,  KUMAR, Krishna, S.

IPC分类号： A61B5/00

CPC分类号： A61B5/412 ,  A61B5/00 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/155 ,  A61B5/157 ,  A61B2017/00172

摘要： A fluid collection and sensor device for placement over at least one artificial opening made in a biological membrane for measuring a characteristic of a biological fluid collected from the tissue through the at least one artificial opening. The device comprises a sensor (110) positioned in a flow path (105) of the biological fluid for contacting a quantity of the biological fluid and generating an indication of a characteristic of the biological fluid. According to one aspect of the invention, a waste fluid storage element (120), such as a reservoir, is positioned in the device (100) to collect the biological fluid after it has made contact with the sensor (110). According to another aspect of the invention, various surfaces of the fluid flow path (105) of the fluid collection and sensor device (100) are treated with an agent to limit or minimize clotting, aggregation or sepsis of the biological fluid, blockage or clogging of the flow path (105) or degradation of the sensor (110). According to still another aspect of the invention, various configurations of a fluid sensor and collection device (100) are provided that are designed to ensure that measurements are made on independent fluid samples.

公开(公告)号：EP2120825A1

公开(公告)日：2009-11-25

申请号：EP08728054.1

申请日：2008-01-22

申请人： Altea Therapeutics Corporation

发明人： MCRAE, Stuart ,  BOWERMAN, Wendy, E. ,  BRAUN, Steven, Wilson ,  SPIEHL, Regina ,  MESSIER, Bernadette ,  FARQUHAR, David ,  KOCH, Erin, Melissa ,  O'LEARY, Jeremiah, Peter ,  FISHER, Mark, James ,  KASCAK, Uros ,  LANTZ, Loren, J. ,  NOVAKOVIC, Zoran ,  EPPSTEIN, Jonathan, A.

IPC分类号： A61F13/02

CPC分类号： A61N1/325 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0476 ,  A61N1/327

摘要： A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.