公开(公告)号：EP1229825B1

公开(公告)日：2012-06-20

申请号：EP00980533.4

申请日：2000-11-17

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： FAUPEL, Mark, L. ,  KUMAR, Krishna ,  FARQUHAR, David ,  VREEKE, Mark ,  SMITH, Alan ,  HATCH, Michael ,  WOODS, Teresa

IPC分类号： A61B5/1486

CPC分类号： A61B5/1486

摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

公开(公告)号：EP1098594B1

公开(公告)日：2007-12-12

申请号：EP99934149.8

申请日：1999-07-20

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： SAMUELS, Mark, A. ,  EPPSTEIN, Jonathan, A. ,  HATCH, Michael, R.

IPC分类号： A61B10/00 ,  A61B5/00

CPC分类号： A61B5/14514 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150969 ,  A61B5/15134 ,  A61B5/155 ,  A61B5/157 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2017/00172

摘要： A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system comprises a tissue interface device (100) suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit (200) coupled to the tissue interface device (100). The tissue interface device (100) comprises a sensor (115) positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor (115) generates a sensor signal representative thereof. The monitor and control unit (200) electrically or optically reads the sensor (115) to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.

公开(公告)号：EP1229836A4

公开(公告)日：2007-05-02

申请号：EP00978245

申请日：2000-11-03

申请人： SPECTRX INC

发明人： BAMBOT SHABBIR B ,  FAUPEL MARK L ,  HARREL TIM ,  AGRAWAL ANANT

IPC分类号： A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4312 ,  A61B5/4331 ,  A61B5/7264

摘要： An apparatus and method according to the invention utilizes a radiation source (20) and processor (44) to combine more than one optical modality (spectroscopic method), including but not limited to fluorescence, absorption, reflectance, polarization anisotropy, and phase modulation, to decouple morphological and biochemical changes associated with tissue changes due to disease, and thus to provide an accurate diagnosis for tissue condition.

公开(公告)号：EP1080361A4

公开(公告)日：2005-08-10

申请号：EP99924312

申请日：1999-05-19

申请人： SPECTRX INC

发明人： BAMBOT SHABBIR ,  FAUPEL MARK L ,  ARCHE GLENN STEVEN

IPC分类号： A61B5/00 ,  G01N21/47 ,  G01N21/49 ,  G01N21/64 ,  G01N15/02 ,  A61N5/06

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  G01N21/474 ,  G01N21/49 ,  G01N21/6486 ,  G01N2021/6484

摘要： An apparatus and method embodying the invention include utilizing a device with a limited number of interrogation devices to accomplish a large number of measurements on a target tissue (50). An instrument embodying the invention includes a plurality of detection devices (54) that are arranged in a predetermined pattern on a tissue contacting face of the instrument. The face of the instrument is located adjacent the target tissue (50), and a plurality of tissue characteristic measurement are simultaneously conducted. The detection devices (54) are moved to a new position, preferably without moving the tissue contacting face, and a second plurality of tissue characteristic measurements are simultaneously conducted. By conducting a series of measurements cycles in this manner, the ultimate resolution of the device is increased, while still obtaining a given resolution, which reduces potential cross-talk errors. Further, a plurality of tissue characteristics are simultaneously obtained from locations spaced across the target tissue (50) during each measurement cycle.

公开(公告)号：EP1164925A1

公开(公告)日：2002-01-02

申请号：EP00921911.4

申请日：2000-04-07

申请人： SPECTRX, Inc.

发明人： KUMAR, Krishna S. ,  PAPP, Joseph ,  FARQUHAR, J., David ,  TAYLOR, Lance ,  SMITH, Alan, M. ,  VREEKE, Mark, S. ,  HATCH, Michael, R. ,  SCHIFFER, Jarad ,  FAUPEL, Mark, L. ,  CONNOLLY, James

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/1495

摘要： The present invention is directed at an assay device for detecting and enabling measurement of an analyte in a fluid. The assay device contains: a) an inlet port to receive fluid; b) a well in fluid communication with the inlet port; c) an outlet port in fluid communication with the well, wherein the outlet port is designed to allow discharge of the fluid; d) at least one first working electrode and at least one reference electrode disposed within the well; e) a quantity of reactant that reacts with the analyte to form a reaction product, wherein the reaction product is in fluid communication with the at least one first working electrode; and f) at least one membrane disposed over or around the reactant to regulate contact of the analyte in the fluid with the reactant.

公开(公告)号：EP1112022A1

公开(公告)日：2001-07-04

申请号：EP99948158.3

申请日：1999-09-10

申请人： SPECTRX Inc.

发明人： BAMBOT, Shabbir, B. ,  FAUPEL, Mark, L. ,  HARRELL, Tim ,  AGRAWAL, Anant

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B1/043 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/7264

摘要： The methods and apparatus according to the invention combine more than one optical modality, including but not limited to, fluorescence, absorption, reflectance, polarization anisotropy, and phase modulation to decouple morphological, biochemical changes associated with tissue changes, thus to provide an accurate diagnosis of the tissue's condition. The apparatus includes a transmit optical fiber bundle (52) to illuminate a target tissue, and optical fibers (54) to receive electromagnetic radiation returned from the target tissue. The processor device (44) analyzes the returned electromagnetic radiation to determine characteristics of the target tissue.

公开(公告)号：EP1059882A1

公开(公告)日：2000-12-20

申请号：EP99911184.2

申请日：1999-03-05

申请人： SPECTRX, Inc. ,  Altea Technologies, Inc.

发明人： EPPSTEIN, Jonathan, A. ,  SAMUELS, Mark ,  HATCH, Michael, R.

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61K41/00 ,  A61M37/00 ,  G01N33/50

CPC分类号： A61B5/15134 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/15136 ,  A61B5/157 ,  A61B2010/008 ,  A61B2017/00172 ,  A61B2562/12 ,  A61K41/0047

摘要： An integrated device (100, 200, 300, 400, 600, 1000) for harvesting a biological fluid from the tissue and analysis of the biological fluid. The device comprises a layer having a porating element disposed thereon to form at least one opening in the tissue. Biological fluid is harvested from the opening of the tissue and placed in contact with a sensor incorporated in the integrated device. The sensor is responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. The porating element may comprise one or more heat conducting elements that are either optically or electrically heated, or one or more mechanical porating elements.

摘要翻译： 一种用于从组织收集生物流体并分析生物流体的集成装置（100,200,300,400,600,1000）。 该装置包括具有设置在其上的临时元件以在组织中形成至少一个开口的层。 从组织的开口收集生物流体并放置成与集成装置中包含的传感器接触。 传感器响应于生物流体以提供生物流体特性的指示，诸如组织间液中分析物的浓度。 该接地元件可以包括一个或多个导热元件，该导热元件可以是光学或电加热的，或者是一个或多个机械定位元件。

公开(公告)号：EP0879011A1

公开(公告)日：1998-11-25

申请号：EP96911278.0

申请日：1996-03-21

申请人： Spectrx, Inc.

发明人： EPPSTEIN, Jonathon, A. ,  SAMUELS, Mark, A. ,  IGNOTZ, Keith, D. ,  NEWMAN, Gregory, J.

IPC分类号： G01N21 ,  A61B5

CPC分类号： A61B5/1495 ,  A61B5/0059 ,  A61B2560/0233

摘要： A disposable calibration device (45) is used to calibrate a measurement system (3) which transmits radiation (39) to a material or tissue (40) in order to effect measurements with a spectrometer (10). The disposable calibration device includes a structure with a window through which radiation (39) can be transmitted, as well as a removable calibration target (270) arranged on the window and capable of returning a portion of the radiation for calibrating the measurement system. The removable calibration target (270) can be peeled off of the window or the perimeter of an opening to allow a measurement to be made on the material or tissue (40). Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the measurement system.

公开(公告)号：EP1059883B1

公开(公告)日：2008-02-06

申请号：EP99911191.7

申请日：1999-03-05

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： EPPSTEIN, Jonathan, A. ,  SAMUELS, Mark ,  HATCH, Michael, R.

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61K41/00 ,  A61M37/00 ,  G01N33/50

CPC分类号： A61B5/15134 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/15136 ,  A61B5/157 ,  A61B2010/008 ,  A61B2017/00172 ,  A61B2562/12 ,  A61K41/0047

摘要： An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum corneum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.

公开(公告)号：EP1059882B1

公开(公告)日：2007-10-17

申请号：EP99911184.2

申请日：1999-03-05

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： EPPSTEIN, Jonathan, A. ,  SAMUELS, Mark ,  HATCH, Michael, R.

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61K41/00 ,  A61M37/00 ,  G01N33/50

CPC分类号： A61B5/15134 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/15136 ,  A61B5/157 ,  A61B2010/008 ,  A61B2017/00172 ,  A61B2562/12 ,  A61K41/0047

摘要： An integrated device (100, 200, 300, 400, 600, 1000) for harvesting a biological fluid from the tissue and analysis of the biological fluid. The device comprises a layer having a porating element disposed thereon to form at least one opening in the tissue. Biological fluid is harvested from the opening of the tissue and placed in contact with a sensor incorporated in the integrated device. The sensor is responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. The porating element may comprise one or more heat conducting elements that are either optically or electrically heated, or one or more mechanical porating elements.

摘要翻译： 一种用于从组织收集生物流体并分析生物流体的集成装置（100,200,300,400,600,1000）。 该装置包括具有设置在其上的临时元件以在组织中形成至少一个开口的层。 从组织的开口收集生物流体并放置成与集成装置中包含的传感器接触。 传感器响应于生物流体以提供生物流体特性的指示，诸如组织间液中分析物的浓度。 该接地元件可以包括一个或多个导热元件，该导热元件可以是光学或电加热的，或者是一个或多个机械定位元件。