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公开(公告)号：EP1140014A2
公开(公告)日：2001-10-10
申请号：EP99967575.4
申请日：1999-12-21
申请人： Alza Corporation
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： An osmotic delivery system having a space efficient piston. The capsule has an interior holding the piston, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.
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公开(公告)号：EP1140014B1
公开(公告)日：2003-03-19
申请号：EP99967575.4
申请日：1999-12-21
申请人： Alza Corporation
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： An osmotic delivery system having a space efficient piston. The capsule has an interior holding the piston, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.
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公开(公告)号：EP1051217A1
公开(公告)日：2000-11-15
申请号：EP98964191.5
申请日：1998-12-21
申请人： ALZA CORPORATION
发明人： AYER, Rupal , JORDAN, Scott, D. , STEWART, Gregory, R. , BERRY, Stephen, A. , ECKENHOFF, James, B. DI
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/1424 , A61M5/1684 , A61M25/0108 , A61M31/002 , A61M2250/00
摘要： Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.
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公开(公告)号：EP1051217B8
公开(公告)日：2004-07-21
申请号：EP98964191.5
申请日：1998-12-21
申请人： ALZA Corporation
发明人： AYER, Rupal , JORDAN, Scott, D. , STEWART, Gregory, R. , BERRY, Stephen, A. , ECKENHOFF, James, B. DI
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/1424 , A61M5/1684 , A61M25/0108 , A61M31/002 , A61M2250/00
摘要： Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.
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公开(公告)号：EP1051217B1
公开(公告)日：2003-08-27
申请号：EP98964191.5
申请日：1998-12-21
发明人： AYER, Rupal , JORDAN, Scott, D. , STEWART, Gregory, R. , BERRY, Stephen, A. , ECKENHOFF, James, B. DI
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/1424 , A61M5/1684 , A61M25/0108 , A61M31/002 , A61M2250/00
摘要： Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.
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