公开(公告)号：EP1670829A1

公开(公告)日：2006-06-21

申请号：EP04775508.7

申请日：2004-10-05

申请人： Amersham Biosciences AB

发明人： VAN ALSTINE, James, Amersham Biosciences AB ,  BERG, Hans ,  BJURLING, Asa, Amersham Biosciences AB

IPC分类号： C07K17/00 ,  C12N5/00 ,  C07C29/00

CPC分类号： C07K17/02 ,  C12N5/0075 ,  C12N2533/30 ,  C12N2533/70

摘要： The present invention relates to a microcarrier onto the surface of which a cationic compound has been immobilised via a guanidine group. The microcarrier is capable of attachment of cells, e.g. via charge-based interaction, and is advantageously used as a support in the culture of cells. Said compound may comprise one or two amino acids, such as arginine (Arg) or a dipeptide. The invention also relates to a method of preparing a polycationic microcarrier, which method comprises to immobilise a compound that comprises at least one guanidine group to an epoxide-activated substrate.