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1.发明公开6-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLMETHYL)-1,6-NAPHTHYRIDIN-5(6H)-ONE DERIVATIVES AS C-MET INHIBITORS 审中-公开6 - （[1,2,4]三唑并[4,3-A]吡啶-3-基甲基）-1,6-萘啶-5（6H） - 邻苯二甲酸C-MET-HEMMER
公开(公告)号：EP3170824A1
公开(公告)日：2017-05-24
申请号：EP16201037.5
申请日：2008-10-14
申请人： Amgen, Inc
发明人： ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin C. , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-Seong , LEWIS, Richard T. , LONGBIN, Liu , LOHMANN, Julia , NORMAN, Mard H. , POTASHMAN, Michele , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/437 , A61P35/00
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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2.发明授权[1,2,4]Triazolo[4,3-a]pyridine derivatives useful as inhibitors of the hepatocyte growth factor receptor 有权吡啶衍生物作为合适的hepatozytenwachstumsfaktorrezeptors的抑制剂[1,2,4]三唑并[4,3-α]
公开(公告)号：EP2081931B1
公开(公告)日：2016-08-31
申请号：EP07810473.4
申请日：2007-07-13
申请人： Amgen Inc.
发明人： ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall , KIM, Tae-Seong , LEWIS, Richard , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark , POTASHMAN, Michele , SIEGMUND, Aaron , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
IPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , A61K31/5025 , A61K31/52 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
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3.发明公开FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR 有权吡啶衍生物作为合适的hepatozytenwachstumsfaktorrezeptors的抑制剂[1,2,4]三唑并[4,3-α]
公开(公告)号：EP2081931A2
公开(公告)日：2009-07-29
申请号：EP07810473.4
申请日：2007-07-13
申请人： Amgen Inc.
发明人： ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall , KIM, Tae-Seong , LEWIS, Richard , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark , POTASHMAN, Michele , SIEGMUND, Aaron , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
IPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , A61K31/5025 , A61K31/52 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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