公开(公告)号：EP1971604B1

公开(公告)日：2012-08-01

申请号：EP06826602.2

申请日：2006-10-23

申请人： Amgen Inc.

发明人： GERMAIN, Julie ,  ASKEW, Benny, C., Jr. ,  BAUER, David ,  CHOQUETTE, Deborah ,  DIPIETRO, Lucian, V. ,  GRACEFFA, Russell ,  HARMANAGE, Jean-Christophe ,  HUANG, Qi ,  KIM, Joseph, L. ,  LA, Daniel ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PATEL, Vinod ,  POTASHMAN, Michele ,  RIAHI, Babak ,  STORZ, Thomas ,  VAN DER PLAS, Simon ,  YANG, Kevin ,  YUAN, Chester, C.

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1773817B1

公开(公告)日：2009-08-26

申请号：EP05791799.9

申请日：2005-07-20

申请人： Amgen Inc.

发明人： YUAN, Chester Chenguang ,  YANG, Kevin ,  VANDERPLAS, Simon ,  RIAHI, Babak ,  POTASHMAN, Michele ,  PATEL, Vinod F. ,  NOMAK, Rana ,  LI, Aiwen ,  HUANG, Qi ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C.

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D217/02 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/443 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D217/02 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

公开(公告)号：EP2424859B1

公开(公告)日：2015-04-08

申请号：EP10718364.2

申请日：2010-04-27

申请人： Amgen, Inc

发明人： ANDREWS, Kristin ,  BO, Yunxin, Y. ,  BOOKER, Shon ,  CEE, Victor, J. ,  D'ANGELO, Noel ,  HERBERICH, Bradley, J. ,  HONG, Fang-Tsao ,  JACKSON, Claire, L., M. ,  LANMAN, Brian, A. ,  LIAO, Hongyu ,  LIU, Longbin ,  NISHIMURA, Nobuko ,  NORMAN, Mark, H. ,  PETTUS, Liping, H. ,  REED, Anthony, B. ,  SMITH, Adrian, L. ,  TADESSE, Seifu ,  TAMAYO, Nuria, A. ,  WU, Bin ,  WURZ, Ryan ,  YANG, Kevin

IPC分类号： C07D401/14 ,  C07D473/00 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：EP2307400B1

公开(公告)日：2014-04-23

申请号：EP09767432.9

申请日：2009-05-29

申请人： Amgen, Inc

发明人： BO, Yunxin Y. ,  BOOKER, Shon ,  BRYAN, Marian ,  DEAK, Holly L. ,  LIU, Longbin ,  ANDREWS, Kristin ,  NISHIMURA, Nobuko ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie ,  SIEGMUND, Aaron C. ,  TAMAYO, Nuria A. ,  YANG, Kevin

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/498 ,  A61K31/502 ,  A61K31/4709 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04

公开(公告)号：EP2183232B1

公开(公告)日：2013-03-06

申请号：EP08794970.7

申请日：2008-08-01

申请人： Amgen, Inc

发明人： BOOKER, Shon ,  D'ANGELO, Noel ,  D'AMICO, Derin C. ,  KIM, Tae-seong ,  LIU, Longbin ,  MEAGHER, Kristin ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie B. ,  SMITH, Adrian L. ,  TAMAYO, Nuria A. ,  WHITTINGTON, Douglas A. ,  XI, Ning ,  YANG, Kevin

IPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  A61K31/423 ,  A61K31/424 ,  A61K31/428 ,  A61K31/429 ,  A61P35/00

CPC分类号： C07D277/82 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D513/04

公开(公告)号：EP1656355A2

公开(公告)日：2006-05-17

申请号：EP04820712.0

申请日：2004-06-21

申请人： AMGEN INC.

发明人： CHEN, Jian, J. ,  ASKEW, Ben, C. ,  BISWAS, Kaustav ,  CHAU, Jennifer, N. ,  D'AMICIO, Derin, C. ,  HARRIED, Scott ,  NGUYEN, Thomas ,  QIAN, Wenyuan ,  ZHU, Jiawang ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  LI, Aiwen ,  LIU, Qingyian ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PETERKIN, Tanya ,  RIAHI, Babak ,  YANG, Kevin ,  YUAN, Chester, Chenguang

IPC分类号： C07D241/00

CPC分类号： C07D241/08 ,  C07D243/08 ,  C07D245/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14

摘要： Compounds (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1519921A2

公开(公告)日：2005-04-06

申请号：EP03763451.6

申请日：2003-07-09

申请人： Amgen Inc.

发明人： HUANG, Qi ,  CHEN, Guoqing ,  LI, Aiwen ,  RIAHI, Babak ,  TASKER, Andrew ,  YANG, Kevin ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/36

CPC分类号： C07D401/12 ,  C07D209/20 ,  C07D213/36 ,  C07D215/12 ,  C07D217/02 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/12 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1881976B1

公开(公告)日：2012-10-17

申请号：EP06751834.0

申请日：2006-04-27

申请人： Amgen Inc.,

发明人： KIM, Tae-Seong ,  BAUER, David ,  BELLON, Steven ,  BOEZIO, Alessandro ,  BOOKER, Shon ,  CHOQUETTE, Deborah ,  D'AMICO, Derin ,  D'ANGELO, Noel ,  DOMINGUEZ, Celia ,  FELLOWS, Ingrid M. ,  GERMAIN, Julie ,  GRACEFFA, Russel ,  HARMANGE, Jean-Cristophe ,  HIRAI, Satoko ,  LA, Daniel ,  LEE, Matthew ,  LIU, Longbin ,  NORMAL, Mark H. ,  POTHASHMAN, Michele ,  ROVETO, Philip ,  XI, Ning ,  SIEGMUND, Aaron C. ,  YANG, Kevin

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  C07D495/04 ,  C07D487/04 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  A61K31/435 ,  A61K31/495 ,  A61P35/00

CPC分类号： C07D413/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

公开(公告)号：EP2424859A1

公开(公告)日：2012-03-07

申请号：EP10718364.2

申请日：2010-04-27

申请人： Amgen, Inc

发明人： ANDREWS, Kristin ,  BO, Yunxin, Y. ,  BOOKER, Shon ,  CEE, Victor, J. ,  D'ANGELO, Noel ,  HERBERICH, Bradley, J. ,  HONG, Fang-Tsao ,  JACKSON, Claire, L., M. ,  LANMAN, Brian, A. ,  LIAO, Hongyu ,  LIU, Longbin ,  NISHIMURA, Nobuko ,  NORMAN, Mark, H. ,  PETTUS, Liping, H. ,  REED, Anthony, B. ,  SMITH, Adrian, L. ,  TADESSE, Seifu ,  TAMAYO, Nuria, A. ,  WU, Bin ,  WURZ, Ryan ,  YANG, Kevin

IPC分类号： C07D401/14 ,  C07D473/00 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.

公开(公告)号：EP2307400A2

公开(公告)日：2011-04-13

申请号：EP09767432.9

申请日：2009-05-29

申请人： Amgen, Inc

发明人： BO, Yunxin Y. ,  BOOKER, Shon ,  BRYAN, Marian ,  DEAK, Holly L. ,  LIU, Longbin ,  ANDREWS, Kristin ,  NISHIMURA, Nobuko ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie ,  SIEGMUND, Aaron C. ,  TAMAYO, Nuria A. ,  YANG, Kevin

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/498 ,  A61K31/502 ,  A61K31/4709 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04

摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X
1 , X
2 , R
1 and Z are as defined herein.