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公开(公告)号：EP3558955A2
公开(公告)日：2019-10-30
申请号：EP17832646.8
申请日：2017-12-21
申请人： Amgen Inc.
发明人： LANMAN, Brian Alan , CEE, Victor J. , PICKRELL, Alexander J. , REED, Anthony B. , YANG, Kevin C. , KOPECKY, David John , WANG, Hui-Ling , LOPEZ, Patricia , ASHTON, Kate , BOOKER, Shon , TEGLEY, Christopher M.
IPC分类号： C07D275/04 , C07D417/04 , C07D471/08 , C07D513/04 , C07D487/10 , C07D487/04 , C07D239/80 , C07D471/04 , C07D401/04 , C07D403/04 , A61K31/428 , A61K31/429 , A61K31/437 , A61K31/517 , A61K31/519 , A61K31/498 , A61K31/4985 , A61P35/00
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2.发明授权SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS 有权取代的胺衍生物及其血管生成有关的疾病的治疗
公开(公告)号：EP1562933B1
公开(公告)日：2008-03-19
申请号：EP03764755.9
申请日：2003-07-15
申请人： AMGEN INC.
发明人： PATEL, Vinod, F. , ASKEW JR, Benny, C. , BOOKER, Shon , CHEN, Guoqing , DIPIETRO, Lucian, V. , GERMAIN, Julie , HABGOOD, Gregory, J. , HUANG, Qi , KIM, Tae-Seong , LI, Aiwen , NISHIMURA, Nobuko , NOMAK, Rana , RIAHI, Babak , YUAN, Chester, Chenguang , ELBAUM, Daniel
IPC分类号： C07D401/12 , C07D401/14 , C07D417/14 , C07D405/14 , C07D407/14 , A61K31/4439 , A61K31/444 , A61K31/4433 , C07D413/14
CPC分类号： C07D471/04 , A61K31/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：EP4403175A3
公开(公告)日：2024-10-02
申请号：EP24151885.1
申请日：2018-09-07
申请人： Amgen Inc.
发明人： LANMAN, Brian Alan , BOOKER, Shon , GOODMAN, Clifford , REED, Anthony B. , LOW, Jonathan D. , WANG, Hui-Ling , CHEN, Ning , MINATTI, Ana Elena , WURZ, Ryan , CEE, Victor J.
IPC分类号： C07D471/04 , A61P35/00 , A61K31/519
CPC分类号： A61P35/00 , A61K31/519 , A61K31/7068 , A61K38/07 , C07D471/04
摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：EP4288435A1
公开(公告)日：2023-12-13
申请号：EP22705655.3
申请日：2022-02-03
申请人： Amgen Inc.
发明人： AMEGADZIE, Albert , BEYLKIN, Diane Jennifer , BOOKER, Shon , BOURBEAU, Matthew Paul , BUTLER, John R. , GREENMAN, Kevin Lloyd , KOHN, Todd J. , LI, Kexue , LIU, Qingyian , MINATTI, Ana Elena , NAVARATNE, Primali Vasundera , PETTUS, Liping H. , RAHIMOFF, Rene , WANG, Hui-Ling , WEIRES, Nicholas Anthony
IPC分类号： C07D471/04 , C07D471/14 , C07D491/048 , C07D491/052 , C07D491/147 , C07D495/04 , C07D498/04 , C07D519/00 , C07B59/00 , A61K31/55 , A61K31/4375 , A61K31/519 , A61K31/4355 , A61K31/437 , A61K31/4365 , A61P35/00
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公开(公告)号：EP4001269A1
公开(公告)日：2022-05-25
申请号：EP21183032.8
申请日：2017-12-21
申请人： Amgen Inc.
发明人： LANMAN, Brian Alan , CEE, Victor J. , PICKRELL, Alexander J. , REED, Anthony B. , YANG, Kevin C. , KOPECKY, David John , WANG, Hui-Ling , LOPEZ, Patricia , ASHTON, Kate , BOOKER, Shon , TEGLEY, Christopher M.
IPC分类号： C07D275/04 , C07D417/04 , C07D471/08 , C07D513/04 , C07D487/10 , C07D487/04 , C07D239/80 , C07D471/04 , C07D401/04 , C07D403/04 , A61K31/428 , A61K31/496 , A61K31/517 , A61K31/502 , A61K31/5025 , A61K31/519 , A61P35/00 , A61P35/02 , A61P35/04
摘要： Provided herein are compounds of formulae (I), (II), (III), (III´), (IV), (IV´) and (V):
as KRAS G12C inhibitors for use in treating cancer, such as e.g. pancreatic, colorectal and lung cancer.
Preferred compounds are e.g. benzoisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives.
An exemplary compound is e.g. 1-(4-(6-(2-bromo-5-hydroxyphenyl)-5-chloro-7-fluorobenzo[c]isothiazol-3-yl)piperazin-1-yl)prop-2-en-1-one (example 1-1):-
公开(公告)号：EP3679040A1
公开(公告)日：2020-07-15
申请号：EP18778775.9
申请日：2018-09-07
申请人： Amgen Inc.
发明人： LANMAN, Brian Alan , BOOKER, Shon , GOODMAN, Clifford , REED, Anthony B. , LOW, Jonathan D. , WANG, Hui-Ling , CHEN, Ning , MINATTI, Ana Elena , WURZ, Ryan , CEE, Victor J.
IPC分类号： C07D471/04 , A61P35/00 , A61K31/519
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7.发明授权6-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLMETHYL)-1,6-NAPHTHYRIDIN-5(6H)-ONE DERIVATIVES AS C-MET INHIBITORS 有权6 - （[1,2,4]三唑并[4,3-A]吡啶-3-基甲基）-1,6-萘啶-5（6H） - 酮衍生物作为C-Met抑制剂
公开(公告)号：EP2231663B1
公开(公告)日：2017-08-02
申请号：EP08870985.2
申请日：2008-10-14
申请人： Amgen Inc.
发明人： ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-Seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
IPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , A61K31/4355
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
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8.发明公开6-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLMETHYL)-1,6-NAPHTHYRIDIN-5(6H)-ONE DERIVATIVES AS C-MET INHIBITORS 审中-公开6 - （[1,2,4]三唑并[4,3-A]吡啶-3-基甲基）-1,6-萘啶-5（6H） - 邻苯二甲酸C-MET-HEMMER
公开(公告)号：EP3170824A1
公开(公告)日：2017-05-24
申请号：EP16201037.5
申请日：2008-10-14
申请人： Amgen, Inc
发明人： ALBRECHT, Brian , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin C. , HARMANGE, Jean-Christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-Seong , LEWIS, Richard T. , LONGBIN, Liu , LOHMANN, Julia , NORMAN, Mard H. , POTASHMAN, Michele , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/437 , A61P35/00
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：EP2118069B1
公开(公告)日：2014-01-01
申请号：EP08724464.6
申请日：2008-01-09
申请人： Amgen Inc.
发明人： BOOKER, Shon , D'ANGELO, Noel , GERMAIN, Julie , HARMANGE, Jean-christophe , KIM, Tae-seong , POTASHMAN, Michele
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D471/04 , A61K31/416 , A61K31/4725 , A61K31/5025 , A61P35/00
CPC分类号： C07D403/12 , C07D231/22 , C07D231/56 , C07D401/12 , C07D471/04
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10.发明公开
公开(公告)号：EP2231663A2
公开(公告)日：2010-09-29
申请号：EP08870985.2
申请日：2008-10-14
申请人： Amgen, Inc
发明人： ALBRECHT, Brian K. , BAUER, David , BELLON, Steven , BODE, Christiane M. , BOOKER, Shon , BOEZIO, Alessandro , CHOQUETTE, Deborah , D'AMICO, Derin , HARMANGE, Jean-christophe , HIRAI, Satoko , HUNGATE, Randall W. , KIM, Tae-seong , LEWIS, Richard T. , LIU, Longbin , LOHMAN, Julia , NORMAN, Mark H. , POTASHMAN, Michelle , SIEGMUND, Aaron C. , SPRINGER, Stephanie , STEC, Markian , XI, Ning , YANG, Kevin , PETERSON, Emily, A. , ROMERO, Karina , COPELAND, Katrina, W.
IPC分类号： C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , A61K31/4355
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选定的化合物对于预防和治疗疾病如HGF介导的疾病是有效的。 本发明包括新化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及癌症等的疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。
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