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1.发明公开QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF 有权喹诺酮类PROLYLHYDROXYLASEHEMMENDER效应和组合物及其应用链接
公开(公告)号：EP1960363A2
公开(公告)日：2008-08-27
申请号：EP06844992.5
申请日：2006-12-08
申请人： Amgen, Inc.
发明人： ALLEN, Jennifer R. , TEGLEY, Christopher M. , BISWAS, Kaustav , BURLI, Roland , MULLER, Kristine M. , FROHN, Michael J. , GOLDEN, Jennifer E. , MERCEDE, Stephanie J. , NEIRA, Susana C. , PETERKIN, Tanya A. N. , HUNGATE, Randall W. , KURZEJA, Robert , YU, Violeta , DAO, Jennifer
IPC分类号： C07D215/22
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
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公开(公告)号：EP2155680B1
公开(公告)日：2013-12-04
申请号：EP08742727.4
申请日：2008-04-09
申请人： Amgen, Inc
发明人： ALLEN, Jennifer R. , BURLI, Roland , GOLDEN, Jennifer E. , MULLER, Kristine M. , REED, Anthony B.
IPC分类号： C07D213/16 , C07D309/04 , C07D333/10 , C07C15/24 , C07C235/04 , A61K31/44 , A61K31/381
CPC分类号： C07D213/16 , C07D213/56 , C07D309/04 , C07D309/06 , C07D333/10 , C07D333/24
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公开(公告)号：EP2155680A1
公开(公告)日：2010-02-24
申请号：EP08742727.4
申请日：2008-04-09
申请人： Amgen, Inc
发明人： ALLEN, Jennifer R. , BURLI, Roland , GOLDEN, Jennifer E. , MULLER, Kristine M. , REED, Anthony B.
IPC分类号： C07D213/16 , C07D309/04 , C07D333/10 , C07C15/24 , C07C235/04 , A61K31/44 , A61K31/381
CPC分类号： C07D213/16 , C07D213/56 , C07D309/04 , C07D309/06 , C07D333/10 , C07D333/24
摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
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4.发明授权QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS AND USES THEREOF 有权喹诺酮类PROLYLHYDROXYLASEHEMMENDER效应和组合物及其应用链接
公开(公告)号：EP1960363B1
公开(公告)日：2014-01-22
申请号：EP06844992.5
申请日：2006-12-08
申请人： Amgen, Inc.
发明人： ALLEN, Jennifer R. , TEGLEY, Christopher M. , BISWAS, Kaustav , BURLI, Roland , MULLER, Kristine M. , FROHN, Michael J. , GOLDEN, Jennifer E. , MERCEDE, Stephanie J. , NEIRA, Susana C. , PETERKIN, Tanya A. N. , HUNGATE, Randall W. , KURZEJA, Robert , YU, Violeta , DAO, Jennifer
IPC分类号： G01N33/542 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D217/04 , C07D215/56 , C07D417/04 , C07D215/22
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
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