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公开(公告)号：EP2601287B1
公开(公告)日：2015-01-07
申请号：EP11748824.7
申请日：2011-08-05
申请人： Amgen Inc.
CPC分类号： C07K16/00 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K2317/14 , C12N5/0037 , C12N2500/32 , C12N2500/46 , C12N2501/105 , C12N2501/998 , C12N2510/02
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公开(公告)号：EP3101029B1
公开(公告)日：2019-04-03
申请号：EP16179980.4
申请日：2009-11-24
申请人： Amgen, Inc
发明人： SUN, Jeonghoon , TAM, Lei-Ting Tony , MICHAELS, Mark Leo , BOONE, Thomas C. , DESHPANDE, Rohini , LI, Yue-Sheng , HAN, Hq
IPC分类号： C07K14/705 , C07K14/71 , C07K14/72
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公开(公告)号：EP2370463B1
公开(公告)日：2016-08-31
申请号：EP09761055.4
申请日：2009-11-24
申请人： Amgen Inc.
发明人： SUN, Jeonghoon , TAM, Lei-Ting Tony , MICHAELS, Mark Leo , BOONE, Thomas C. , DESHPANDE, Rohini , LI, Yue-Sheng , HAN, Hq
IPC分类号： C07K14/495 , C07K14/71
CPC分类号： C07K14/71 , A61K38/00 , C07K14/495
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5.发明公开VARIANTS OF ACTIVIN IIB RECEPTOR POLYPEPTIDES AND USES THEREOF 审中-公开VARIANTEN VON ACTIVIN IIB REZEPTORPOLYPEPTIDEN UND VERWENDUNGEN DAVON
公开(公告)号：EP3101029A1
公开(公告)日：2016-12-07
申请号：EP16179980.4
申请日：2009-11-24
申请人： Amgen, Inc
发明人： SUN, Jeonghoon , TAM, Lei-Ting Tony , MICHAELS, Mark Leo , BOONE, Thomas C. , DESHPANDE, Rohini , LI, Yue-Sheng , HAN, Hq
IPC分类号： C07K14/705 , C07K14/71 , C07K14/72
CPC分类号： C07K14/71 , A61K38/00 , C07K14/495
摘要： The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
摘要翻译： 本发明提供稳定的活化素IIB受体多肽和能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的蛋白质。 本发明还提供能够产生稳定的多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了治疗肌肉消瘦疾病和代谢紊乱的组合物和方法。
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公开(公告)号：EP2601287A1
公开(公告)日：2013-06-12
申请号：EP11748824.7
申请日：2011-08-05
申请人： Amgen Inc.
CPC分类号： C07K16/00 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K2317/14 , C12N5/0037 , C12N2500/32 , C12N2500/46 , C12N2501/105 , C12N2501/998 , C12N2510/02
摘要： The present invention relates to the culture of animal cells in serum-free culture medium. The present invention provides particular dipeptides that can improve recombinant protein production and cell viability in such cultures, especially in the absence of peptones.
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7.发明公开VARIANTS OF ACTIVIN IIB RECEPTOR POLYPEPTIDES AND USES THEREOF 有权EINE STABLISIERTE ACTIVIN IIB RECEPTOR VARIANTE
公开(公告)号：EP2370463A2
公开(公告)日：2011-10-05
申请号：EP09761055.4
申请日：2009-11-24
申请人： Amgen Inc.
发明人： SUN, Jeonghoon , TAM, Lei-Ting Tony , MICHAELS, Mark, Leo , BOONE, Thomas, C. , DESHPANDE, Rohini , LI, Yue-Sheng , HAN, Hq
IPC分类号： C07K14/705 , C07K14/71 , C07K14/72
CPC分类号： C07K14/71 , A61K38/00 , C07K14/495
摘要： The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
摘要翻译： 本发明提供稳定的活化素IIB受体多肽和能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的蛋白质。 本发明还提供能够产生稳定的多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了治疗肌肉消瘦疾病和代谢紊乱的组合物和方法。
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