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公开(公告)号：EP3385279A1
公开(公告)日：2018-10-10
申请号：EP18173194.4
申请日：2010-03-19
申请人： Amgen Inc.
发明人： WALKER, Kenneth, W. , LI, Yue-Sheng , BOONE, Thomas, C. , MIN, HoSung , TALVENHEIMO, Jane , ARORA, Taruna , JACOBSEN, Frederick, W. , DOELLGAST, George
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：EP3385279B1
公开(公告)日：2020-02-26
申请号：EP18173194.4
申请日：2010-03-19
申请人： Amgen Inc.
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公开(公告)号：EP2408814B1
公开(公告)日：2018-11-21
申请号：EP10754210.2
申请日：2010-03-19
申请人： Amgen Inc.
发明人： WALKER, Kenneth, W. , LI, Yue-Sheng , BOONE, Thomas, C. , MIN, HoSung , TALVENHEIMO, Jane , ARORA, Taruna , JACOBSEN, Frederick, W. , DOELLGAST, George
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：EP2408814A2
公开(公告)日：2012-01-25
申请号：EP10754210.2
申请日：2010-03-19
申请人： Amgen, Inc
发明人： WALKER, Kenneth, W. , LI, Yue-Sheng , BOONE, Thomas, C. , MIN, HoSung , TALVENHEIMO, Jane , ARORA, Taruna , JACOBSEN, Frederick, W. , DOELLGAST, George
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了具有SEQ ID NO：4的氨基酸序列或其药学上可接受的盐的物质的组合物，包括包含与ShK，HmK和AETX-K有关的毒素肽类似物的实施方案，以及含有它们的药物组合物或药物以及 药学上可接受的载体。 一些实施方案包括半衰期延长部分。 还公开了预防或减轻多发性硬化症状的复发的方法以及使用该组合物治疗自身免疫病症的方法。
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