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公开(公告)号：EP3385279A1
公开(公告)日：2018-10-10
申请号：EP18173194.4
申请日：2010-03-19
申请人： Amgen Inc.
发明人： WALKER, Kenneth, W. , LI, Yue-Sheng , BOONE, Thomas, C. , MIN, HoSung , TALVENHEIMO, Jane , ARORA, Taruna , JACOBSEN, Frederick, W. , DOELLGAST, George
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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2.发明公开A NUCLEIC ACID DIAGNOSTIC METHOD USING RIBOPROBES, RNAse DIGESTION, AND MOLECULAR WEIGHT EXCLUSION CHROMATOGRAPHY 失效ON NUCLEIC基础的诊断MWTHODE BY RNA样品，RNA酶消化和分子量排阻色谱法
公开(公告)号：EP0738331A1
公开(公告)日：1996-10-23
申请号：EP94931951.0
申请日：1994-10-19
申请人： AMGEN INC.
IPC分类号： C12Q1
CPC分类号： C12Q1/6816 , C12Q2565/137 , C12Q2525/207 , C12Q2521/301
摘要： This invention is drawn to improved methods for detecting particular nucleic acid sequences via nucleic acid hybridization. Disclosed is a diagnostic method wherein detectably labeled riboprobes are hybridized in solution to complementary nucleic acid sequences encoded by target nucleic acid molecules. Following hybridization, RNAse digestion is used to degrade unhybridized probe molecules, after which chromatographic separation is employed to isolate probe-target hybrids. This method improves the detection limit of nucleic acid hybridization and is generally useful in medical diagnostics, forensics, and molecular biology research.
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公开(公告)号：EP3385279B1
公开(公告)日：2020-02-26
申请号：EP18173194.4
申请日：2010-03-19
申请人： Amgen Inc.
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公开(公告)号：EP2408816B1
公开(公告)日：2019-09-04
申请号：EP10708688.6
申请日：2010-03-16
申请人： Amgen Inc.
IPC分类号： C07K16/28
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公开(公告)号：EP2408814B1
公开(公告)日：2018-11-21
申请号：EP10754210.2
申请日：2010-03-19
申请人： Amgen Inc.
发明人： WALKER, Kenneth, W. , LI, Yue-Sheng , BOONE, Thomas, C. , MIN, HoSung , TALVENHEIMO, Jane , ARORA, Taruna , JACOBSEN, Frederick, W. , DOELLGAST, George
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：EP2408816A2
公开(公告)日：2012-01-25
申请号：EP10708688.6
申请日：2010-03-16
申请人： Amgen Inc.
IPC分类号： C07K16/28
CPC分类号： C07K16/2839 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
摘要翻译： 公开了α4β7异二聚体特异性抗原结合蛋白，编码它们的核酸以及制备和使用它们的方法。
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公开(公告)号：EP2408814A2
公开(公告)日：2012-01-25
申请号：EP10754210.2
申请日：2010-03-19
申请人： Amgen, Inc
发明人： WALKER, Kenneth, W. , LI, Yue-Sheng , BOONE, Thomas, C. , MIN, HoSung , TALVENHEIMO, Jane , ARORA, Taruna , JACOBSEN, Frederick, W. , DOELLGAST, George
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了具有SEQ ID NO：4的氨基酸序列或其药学上可接受的盐的物质的组合物，包括包含与ShK，HmK和AETX-K有关的毒素肽类似物的实施方案，以及含有它们的药物组合物或药物以及 药学上可接受的载体。 一些实施方案包括半衰期延长部分。 还公开了预防或减轻多发性硬化症状的复发的方法以及使用该组合物治疗自身免疫病症的方法。
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公开(公告)号：EP1692174A2
公开(公告)日：2006-08-23
申请号：EP04810550.6
申请日：2004-11-04
申请人： AMGEN INC.
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2317/56
摘要： Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain constant regions derived from cynomolgus monkeys. Chimeric antibodies with cynomolgus monkey constant regions are described.
摘要翻译： 编码的核苷酸序列和包含来源于食蟹猴的重链和轻链恒定区的氨基酸序列。 描述了具有食蟹猴恒定区的嵌合抗体。
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