公开(公告)号：EP1416933B8

公开(公告)日：2008-08-27

申请号：EP02750299.6

申请日：2002-07-25

申请人： Amgen Inc.

发明人： FOTSCH, Christopher, H. ,  CROGHAN, Michael ,  DOHERTY, Elizabeth, M. ,  KELLY, Michael, G. ,  NORMAN, Mark, H. ,  SMITH,Duncan, M. ,  TAMAYO, Nuria ,  XI, Ning ,  XU, Shimin

IPC分类号： A61K31/445 ,  C07D211/28 ,  C07K5/078 ,  A61P3/04 ,  C07D401/12 ,  C07D211/34 ,  C07D401/14

CPC分类号： C07K5/06191 ,  A61K38/00 ,  C07D211/28 ,  C07D211/34 ,  C07D401/12 ,  C07D401/14 ,  C07K5/06139

公开(公告)号：EP1463714A2

公开(公告)日：2004-10-06

申请号：EP02799927.5

申请日：2002-12-10

申请人： Amgen Inc.

发明人： BO, Yunxin, Y. ,  CHAKRABARTI, Partha, P. ,  CHEN, Ning ,  DOHERTY, Elizabeth, M. ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  KELLY, Michael, G. ,  LIU, Qingyian ,  NORMAN, Mark, Henry ,  WANG, Xianghong ,  ZHU, Jiawang

IPC分类号： C07C233/11 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D265/36 ,  C07D241/40 ,  A61K31/4418 ,  A61K31/47 ,  A61P31/12

CPC分类号： C07D471/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/40 ,  C07D231/56 ,  C07D233/38 ,  C07D237/20 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having the general structure of the Formula (I) and compositions containing them, for treatment of various diseases.

公开(公告)号：EP1720868A1

公开(公告)日：2006-11-15

申请号：EP05722962.7

申请日：2005-02-11

申请人： AMGEN INC.

发明人： WANG, Hui-Ling ,  BALAN, Chenera ,  DOHERTY, Elizabeth, M. ,  FALSEY, James, Richard ,  GORE, Vijay, Keshav ,  KATON, Jodie ,  NORMAN, Mark, H.

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R1 - R4 and X are as defined in the claims.

公开(公告)号：EP1546116A1

公开(公告)日：2005-06-29

申请号：EP03785220.9

申请日：2003-08-08

申请人： Amgen Inc.

发明人： CHAKRABARTI, Partha, P ,  CHEN, Ning ,  DOHERTY, Elizabeth, M. ,  DOMINGUEZ, Celia ,  FALSEY, James, Richard ,  FOTSH, Christopher, H. ,  HULME, Christopher ,  KATON, Jodie ,  NIXEY, Thomas ,  NORMAN, Mark, H. ,  OGNYANOV, Vassil, I. ,  PETTUS, Liping, H. ,  RZASA, Robert, Michael ,  STEC, Markian ,  WANG, Hui-Ling ,  ZHU, Jiawang

IPC分类号： C07D239/34 ,  C07D239/38 ,  C07D417/12 ,  C07D401/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/501 ,  A61K31/506 ,  A61K31/505 ,  A61K31/4427 ,  A61K31/5377 ,  A61K31/551 ,  A61P29/00

CPC分类号： C07D231/40 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/56 ,  C07D233/38 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：EP2600874B1

公开(公告)日：2015-03-04

申请号：EP11781042.4

申请日：2011-05-04

申请人： Amgen, Inc

发明人： BRYAN, Marian, C. ,  CHENG, Alan, C. ,  DOHERTY, Elizabeth, M. ,  FALSEY, James, R. ,  FELLOWS, Ingrid, M. ,  KIM, Joseph, L. ,  LEWIS, Richard, T. ,  POTASHMAN, Michele, H. ,  WHITTINGTON, Douglas, A.

IPC分类号： C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D405/14 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D409/14 ,  A61K31/51 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP2600874A1

公开(公告)日：2013-06-12

申请号：EP11781042.4

申请日：2011-05-04

申请人： Amgen, Inc

发明人： BRYAN, Marian, C. ,  CHENG, Alan, C. ,  DOHERTY, Elizabeth, M. ,  FALSEY, James, R. ,  FELLOWS, Ingrid, M. ,  KIM, Joseph, L. ,  LEWIS, Richard, T. ,  POTASHMAN, Michele, H. ,  WHITTINGTON, Douglas, A.

IPC分类号： A61K31/501 ,  A61K31/535 ,  C07D401/00 ,  C07D403/00

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Compounds of Formula I are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

摘要翻译： 式I化合物是间变性淋巴瘤激酶的有用抑制剂。 式I化合物具有以下结构：其中变量的定义在本文中提供。

公开(公告)号：EP1542692B1

公开(公告)日：2011-01-05

申请号：EP03755509.1

申请日：2003-05-20

申请人： AMGEN INC.

发明人： DOHERTY, Elizabeth, M. ,  ZHU, Jiawang ,  STEC, Markian ,  NORMAN, Mark, H. ,  FOTSCH, Christopher, H. ,  CHEN, Ning ,  CHAKRABARTI, Partha, P. ,  OGNYANOV, Vassil I. ,  WANG, Hui-Ling ,  WANG, Xianghong ,  ARASASINGHAM, Premilla ,  PETTUS, Liping.H

IPC分类号： A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  C07D417/12 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D471/04 ,  C07D417/14

CPC分类号： C07D231/40 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/56 ,  C07D233/38 ,  C07D237/20 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：EP1542692A1

公开(公告)日：2005-06-22

申请号：EP03755509.1

申请日：2003-05-20

申请人： Amgen Inc.

发明人： DOHERTY, Elizabeth, M. ,  ZHU, Jiawang ,  STEC, Markian ,  NORMAN, Mark, H. ,  FOTSCH, Christopher, H. ,  CHEN, Ning ,  CHAKRABARTI, Partha, P. ,  OGNYANOV, Vassil I. ,  WANG, Hui-Ling ,  WANG, Xianghong ,  ARASASINGHAM, Premilla ,  PETTUS, Liping.H

IPC分类号： A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  C07D417/12 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D471/04 ,  C07D417/14

CPC分类号： C07D231/40 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/56 ,  C07D233/38 ,  C07D237/20 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：EP1720868B1

公开(公告)日：2009-11-04

申请号：EP05722962.7

申请日：2005-02-11

申请人： AMGEN INC.

发明人： WANG, Hui-Ling ,  BALAN, Chenera ,  DOHERTY, Elizabeth, M. ,  FALSEY, James, Richard ,  GORE, Vijay, Keshav ,  KATON, Jodie ,  NORMAN, Mark, H.

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R1 - R4 and X are as defined in the claims.

公开(公告)号：EP1603905A1

公开(公告)日：2005-12-14

申请号：EP04709532.8

申请日：2004-02-09

申请人： AMGEN INC.

发明人： DOHERTY, Elizabeth, M. ,  HAN, Nianhe ,  HUNGATE, Randall, W. ,  LIU, Qingyian ,  NORMAN, Mark, H. ,  XI, Ning ,  XU, Shimin ,  FOTSCH, Christopher, H.

IPC分类号： C07D417/04 ,  C07D417/12 ,  C07D403/04 ,  C07D277/20 ,  C07D233/66 ,  C07D263/34 ,  A61P29/00

CPC分类号： C07D233/90 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.