公开(公告)号：EP2139843B1

公开(公告)日：2013-12-25

申请号：EP08742774.6

申请日：2008-04-10

申请人： Amgen, Inc

发明人： BROWN, Sean, P. ,  DRANSFIELD, Paul ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, Xian, Yun ,  KOHN, Todd, J. ,  PATTAROPONG, Vatee ,  VIMOLRATANA, Marc ,  SCHMITT, Michael, J.

IPC分类号： C07C59/68 ,  C07C59/72 ,  C07D261/08 ,  A61K31/41 ,  A61K31/19 ,  A61P3/00

CPC分类号： C07C59/68 ,  C07C59/72 ,  C07D261/08

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP2139843A1

公开(公告)日：2010-01-06

申请号：EP08742774.6

申请日：2008-04-10

申请人： Amgen, Inc

发明人： BROWN, Sean, P. ,  DRANSFIELD, Paul ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, Xian, Yun ,  KOHN, Todd, J. ,  PATTAROPONG, Vatee ,  VIMOLRATANA, Marc ,  SCHMITT, Michael, J.

IPC分类号： C07C59/68 ,  C07C59/72 ,  C07D261/08 ,  A61K31/41 ,  A61K31/19 ,  A61P3/00

CPC分类号： C07C59/68 ,  C07C59/72 ,  C07D261/08

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula (I) where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP1585511B1

公开(公告)日：2013-01-23

申请号：EP03814219.6

申请日：2003-12-19

申请人： Amgen Inc.

发明人： FU, Zice ,  HUANG, Xi, Alan ,  LIU, Jiwen ,  MEDINA, Julio, C. ,  SCHMITT, Michael, J. ,  TANG, Lucy, H. ,  WANG, Yingcai ,  XU, Qingge

IPC分类号： A61K31/18 ,  C07C205/37 ,  C07C233/75 ,  C07C271/28 ,  C07C275/42 ,  C07C311/08 ,  C07C311/21 ,  C07D209/22 ,  C07D213/71 ,  C07D215/36 ,  C07D233/84 ,  C07D243/12 ,  C07D333/34 ,  C07D257/04 ,  C07D307/91 ,  C07D295/192 ,  C07C317/44 ,  A61P29/00 ,  A61P37/08 ,  A61P11/06

CPC分类号： C07C205/37 ,  C07C205/56 ,  C07C233/75 ,  C07C271/28 ,  C07C275/42 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C317/44 ,  C07C2601/04 ,  C07C2601/08 ,  C07D209/22 ,  C07D209/26 ,  C07D213/71 ,  C07D215/36 ,  C07D233/84 ,  C07D243/12 ,  C07D243/24 ,  C07D257/04 ,  C07D295/192 ,  C07D307/91 ,  C07D333/34 ,  C07D333/62

公开(公告)号：EP2064193A1

公开(公告)日：2009-06-03

申请号：EP07837816.3

申请日：2007-09-06

申请人： Amgen, Inc

发明人： BECK, Hilary ,  DRANSFIELD, Paul ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, XianYun ,  KOHN, Todd, J. ,  LAI, SuJen ,  LIU, Jinqian ,  LIU, Jiwen ,  MA, Zhihua ,  SCHMITT, Michael, J. ,  SHARMA, Rajiv ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  WANG, Zhongyu ,  MEDINA, Julio, C.

IPC分类号： C07D261/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  A61K31/42 ,  A61K31/422 ,  A61P3/10 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10

CPC分类号： C07D261/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP2001844A2

公开(公告)日：2008-12-17

申请号：EP07752941.0

申请日：2007-03-12

申请人： Amgen, Inc

发明人： SHARMA, Rajiv ,  AKERMAN, Michelle ,  CARDOZO, Mario, G. ,  HOUZE, Jonathan, B. ,  LI, An-Rong ,  LIU, Jinqian ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio, C. ,  SCHMITT, Michael, J. ,  SUN, Ying ,  WANG, Yingcai ,  WANG, Zhongyu ,  ZHU, Liusheng

IPC分类号： C07D209/08 ,  C07D209/46 ,  C07D215/22 ,  C07D277/24 ,  C07D311/74 ,  C07D313/08 ,  C07D417/12 ,  C07D498/04 ,  C07C59/54 ,  C07C59/72 ,  A61K31/426 ,  A61P3/10

CPC分类号： C07C57/62 ,  C07C59/64 ,  C07C59/72 ,  C07D209/08 ,  C07D209/46 ,  C07D215/20 ,  C07D215/227 ,  C07D277/24 ,  C07D311/58 ,  C07D311/74 ,  C07D311/76 ,  C07D313/08 ,  C07D417/12 ,  C07D498/04

摘要： Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject formula (I) (II) where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.

公开(公告)号：EP1924546A1

公开(公告)日：2008-05-28

申请号：EP06814336.1

申请日：2006-09-08

申请人： Amgen, Inc

发明人： AKERMAN, Michelle ,  BROWN, Sean ,  HOUZE, Jonathan, B. ,  LIU, Jinqian ,  MA, Zhihua ,  MEDINA, Julio, C. ,  QIU, Wei ,  SCHMITT, Michael, J. ,  WANG, Yingcai ,  ZHU, Liusheng ,  LIU Jiwen ,  SHARMA, Rajiv

IPC分类号： C07C59/72

CPC分类号： C07D333/24 ,  C07C59/72 ,  C07D231/12 ,  C07D233/26 ,  C07D233/64 ,  C07D239/26 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D317/54 ,  C07D333/16

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: (F) where the definitions of the variables Q, L1, , L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.