公开(公告)号：EP1753736A2

公开(公告)日：2007-02-21

申请号：EP05756354.6

申请日：2005-05-24

申请人： Amgen Inc. ,  BIOVITRUM AB

发明人： HENRIKSSON, Martin ,  HOMAN, Evert ,  JOHANSSON, Lars ,  VALLGARDA, Jerk ,  WILLIAMS, Meredith ,  BERCOT, Eric ,  FOTSCH, Christopher, H. ,  LI, Aiwen ,  CAI, Guolin ,  HUNGATE, Randall, W. ,  YUAN, Chester, Chenguang ,  TEGLEY, Chirstopher ,  ST. JEAN, David ,  HAN, Nianhe ,  HUANG, Qi ,  LIU, Qingyian ,  BARTBERGER, Michael D. ,  MONIZ, George, A. ,  FRIZZLE, Matthew, J.

IPC分类号： C07D277/54 ,  C07D263/48 ,  A61K31/42 ,  A61K31/426 ,  A61P3/04 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P19/10 ,  A61P31/12 ,  A61P29/00 ,  A61P25/28 ,  A61P25/24

CPC分类号： C07D417/06 ,  C07D263/34 ,  C07D263/48 ,  C07D275/03 ,  C07D277/42 ,  C07D277/54 ,  C07D277/60 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  C07F7/1856

摘要： The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

公开(公告)号：EP1753736B1

公开(公告)日：2008-12-17

申请号：EP05756354.6

申请日：2005-05-24

申请人： Amgen Inc. ,  BIOVITRUM AB

发明人： HENRIKSSON, Martin ,  HOMAN, Evert ,  JOHANSSON, Lars ,  VALLGARDA, Jerk ,  WILLIAMS, Meredith ,  BERCOT, Eric ,  FOTSCH, Christopher, H. ,  LI, Aiwen ,  CAI, Guolin ,  HUNGATE, Randall, W. ,  YUAN, Chester, Chenguang ,  TEGLEY, Chirstopher ,  ST. JEAN, David ,  HAN, Nianhe ,  HUANG, Qi ,  LIU, Qingyian ,  BARTBERGER, Michael D. ,  MONIZ, George, A. ,  FRIZZLE, Matthew, J.

IPC分类号： C07D277/54 ,  C07D263/48 ,  A61K31/42 ,  A61K31/426 ,  A61P3/04 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P19/10 ,  A61P31/12 ,  A61P29/00 ,  A61P25/28 ,  A61P25/24

CPC分类号： C07D417/06 ,  C07D263/34 ,  C07D263/48 ,  C07D275/03 ,  C07D277/42 ,  C07D277/54 ,  C07D277/60 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  C07F7/1856

摘要： The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

公开(公告)号：EP3802535A1

公开(公告)日：2021-04-14

申请号：EP19734958.2

申请日：2019-05-31

申请人： Amgen Inc.

发明人： BOOKER, Shon ,  ALLEN, John Gordon ,  LANMAN, Brian Alan ,  WURZ, Ryan Paul ,  CHEN, Ning ,  CEE, Victor J. ,  LOPEZ, Patricia ,  SIEGMUND, Aaron C. ,  BARTBERGER, Michael D.

IPC分类号： C07D471/04 ,  C07D471/10 ,  A61P35/00 ,  A61K31/438 ,  A61K31/4375

公开(公告)号：EP3790886A1

公开(公告)日：2021-03-17

申请号：EP19725595.3

申请日：2019-05-09

申请人： Amgen Inc.

发明人： MINATTI, Ana Elena ,  LOW, Jonathan D. ,  WURZ, Ryan Paul ,  LANMAN, Brian Alan ,  CEE, Victor J. ,  BARTBERGER, Michael D. ,  CHU-MOYER, Margaret

IPC分类号： C07D513/04 ,  A61P35/00 ,  A61K31/549

公开(公告)号：EP3697410A1

公开(公告)日：2020-08-26

申请号：EP18867844.5

申请日：2018-10-18

申请人： Amgen Inc.

发明人： BARTBERGER, Michael D. ,  CHAKKA, Nagasree ,  GAO, Hua ,  GUZMAN-PEREZ, Angel ,  HORNE, Daniel B. ,  HUA, Zihao ,  KIEFFER, Madeleine ,  LIN, Daniel C. H. ,  MILGRAM, Benjamin Charles ,  PANTELEEV, Jane ,  SCHENKEL, Laurie ,  STELLWAGEN, John ,  WEISS, Matthew ,  WHITE, Ryan D. ,  ZHAO, Wei

IPC分类号： A61K31/40 ,  A61K31/50 ,  A61K31/5025 ,  C07D487/00 ,  C07D487/02 ,  C07D487/04