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公开(公告)号：EP1951696A2
公开(公告)日：2008-08-06
申请号：EP06844335.7
申请日：2006-11-13
申请人： Amgen Inc. , BIOVITRUM AB
发明人： HENRIKSSON, Martin , HOMAN, Evert , JOHANSSON, Lars , VALLGARDA, Jerk , WILLIAMS, Meredith , BERCOT, Eric, A. , FOTSCH, Christopher, H. , LI, Aiwen , CAI, Guolin , HUNGATE, Randall, W. , YUAN, Chester, Chenguang , TEGLEY, Christopher , ST. JEAN, David, J., Jr. , HAN, Nianhe , HUANG, Qi , LIU, Qingyian , BARTBEGER, Michael, D. , MONIZ, George, A. , FRIZZLE, Matthew, J. , MARSHALL, Teresa, L.
IPC分类号： C07D277/54 , C07D277/60 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , A61K31/426 , A61K31/427
CPC分类号： C07D277/54 , C07D277/60 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11- β-hydroxysteroid dehydrogenase type 1 enzyme.
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公开(公告)号：EP1753736A2
公开(公告)日：2007-02-21
申请号：EP05756354.6
申请日：2005-05-24
申请人： Amgen Inc. , BIOVITRUM AB
发明人： HENRIKSSON, Martin , HOMAN, Evert , JOHANSSON, Lars , VALLGARDA, Jerk , WILLIAMS, Meredith , BERCOT, Eric , FOTSCH, Christopher, H. , LI, Aiwen , CAI, Guolin , HUNGATE, Randall, W. , YUAN, Chester, Chenguang , TEGLEY, Chirstopher , ST. JEAN, David , HAN, Nianhe , HUANG, Qi , LIU, Qingyian , BARTBERGER, Michael D. , MONIZ, George, A. , FRIZZLE, Matthew, J.
IPC分类号： C07D277/54 , C07D263/48 , A61K31/42 , A61K31/426 , A61P3/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P19/10 , A61P31/12 , A61P29/00 , A61P25/28 , A61P25/24
CPC分类号： C07D417/06 , C07D263/34 , C07D263/48 , C07D275/03 , C07D277/42 , C07D277/54 , C07D277/60 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/10 , C07F7/1856
摘要： The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
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公开(公告)号：EP1753736B1
公开(公告)日：2008-12-17
申请号：EP05756354.6
申请日：2005-05-24
申请人： Amgen Inc. , BIOVITRUM AB
发明人： HENRIKSSON, Martin , HOMAN, Evert , JOHANSSON, Lars , VALLGARDA, Jerk , WILLIAMS, Meredith , BERCOT, Eric , FOTSCH, Christopher, H. , LI, Aiwen , CAI, Guolin , HUNGATE, Randall, W. , YUAN, Chester, Chenguang , TEGLEY, Chirstopher , ST. JEAN, David , HAN, Nianhe , HUANG, Qi , LIU, Qingyian , BARTBERGER, Michael D. , MONIZ, George, A. , FRIZZLE, Matthew, J.
IPC分类号： C07D277/54 , C07D263/48 , A61K31/42 , A61K31/426 , A61P3/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P19/10 , A61P31/12 , A61P29/00 , A61P25/28 , A61P25/24
CPC分类号： C07D417/06 , C07D263/34 , C07D263/48 , C07D275/03 , C07D277/42 , C07D277/54 , C07D277/60 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/10 , C07F7/1856
摘要： The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
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公开(公告)号：EP1631558A1
公开(公告)日：2006-03-08
申请号：EP04734460.1
申请日：2004-05-21
申请人： BIOVITRUM AB
发明人： WILLIAMS, Meredith , PYRING, David , VAEGBERG, Jan , HENRIKSSON, Martin , NILSSON, Cecilia , NILSSON, Catrine
IPC分类号： C07D285/08 , C07D409/12 , C07D409/14 , A61K31/433 , A61P3/10 , A61P3/04 , A61P19/10 , A61P17/00
CPC分类号： A61K31/433 , A61K31/4709 , A61K31/5377 , C07D285/08 , C07D285/135 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
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公开(公告)号：EP1461333A1
公开(公告)日：2004-09-29
申请号：EP02789088.8
申请日：2002-11-22
申请人： BIOVITRUM AB
IPC分类号： C07D333/36 , A61K31/381 , A61P3/00 , A61P9/12 , A61P19/10 , A61P25/00 , A61P27/06 , A61P29/00
CPC分类号： C07D409/12 , A61K31/381 , A61K31/433 , C07D333/36 , C07D409/14
摘要： The present invention relates to compounds with the formula (I)and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-b-hydroxysteroid dehydrogenase type 1 enzyme.
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公开(公告)号：EP1461327A1
公开(公告)日：2004-09-29
申请号：EP02789089.6
申请日：2002-11-22
申请人： BIOVITRUM AB
IPC分类号： C07D285/08 , C07D285/135 , A61K31/433 , A61P3/00 , A61P9/12 , A61P19/10 , A61P25/00 , A61P27/06 , A61P29/00 , A61P31/00
CPC分类号： C07D285/08 , A61K31/381 , A61K31/433 , C07D231/12 , C07D233/56 , C07D249/08 , C07D285/135 , C07D333/36 , C07D409/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-b-hydroxysteroid dehydrogenase type 1 enzyme.
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