公开(公告)号：EP1828248A2

公开(公告)日：2007-09-05

申请号：EP05855109.4

申请日：2005-12-20

申请人： AMGEN INC.

发明人： CALZONE, Frank, J. ,  DESHPANDE, Rajendra, V. ,  TSAI, Mei-Mei

IPC分类号： C07K16/22 ,  A61K39/395 ,  A61P5/00 ,  A61P9/10 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2863 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/14 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric antiIGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-IR-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.

公开(公告)号：EP1272518A2

公开(公告)日：2003-01-08

申请号：EP01924429.2

申请日：2001-03-29

申请人： Amgen, Inc.

发明人： WELCHER, Andrew, A. ,  CALZONE, Frank, J.

IPC分类号： C07K14/705 ,  C12N15/12 ,  C12N15/63 ,  G01N33/53 ,  C12N15/11 ,  C12N5/12 ,  C07K16/18 ,  A61K38/16 ,  A61K48/00 ,  C12N15/62 ,  A61F2/02 ,  A01K67/027

CPC分类号： C07K16/2887 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K14/705 ,  C07K14/70535 ,  C07K16/28

摘要： Novel CD20/IgE-receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing CD20/IgE-receptor like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with CD20/IgE-receptor like polypeptides.

公开(公告)号：EP1239870A1

公开(公告)日：2002-09-18

申请号：EP00982398.0

申请日：2000-12-04

申请人： Amgen Inc.,

发明人： CALZONE, Frank, J. ,  LUETHY, Roland ,  BOEDIGHEIMER, Michael, J. ,  ZHU, Jun ,  CHUNG, Young-ah ,  JING, Shuqian

IPC分类号： A61K38/20 ,  C07K14/47 ,  C07K16/24 ,  C12N15/25 ,  A01K67/027 ,  C12N15/62 ,  C12N5/10 ,  C12N5/12 ,  G01N33/53

CPC分类号： C07K14/54 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/021

摘要： The present invention provides novel Interleukin-1 Receptor Antagonist-Like (IL-1ra-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IL-1ra-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IL-1ra-L polypeptides.

公开(公告)号：EP0870023A1

公开(公告)日：1998-10-14

申请号：EP96945279.0

申请日：1996-12-20

申请人： AMGEN INC.

发明人： BOYLE, William, J. ,  LACEY, David, L. ,  CALZONE, Frank, J. ,  CHANG, Ming-Shi

IPC分类号： A01K67 ,  A61K35 ,  A61K38 ,  A61K48 ,  A61P43 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  G01N33 ,  C12R1

CPC分类号： C07K14/70578 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

摘要： The present invention discloses a secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.